DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and Abcg4

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001100286.2	Gene:	Abcg4 / 300664	RGDID:	1305840	Length:	646	Species:	Rattus norvegicus

Alignment Length:	754	Identity:	155/754 - (20%)
Similarity:	280/754 - (37%)	Gaps:	203/754 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 LGCVFPGPG----------GLKRPMFFFLDPKTYMKRQRNEYTTTPRGTHA-------IIITELC 467
            :||.. |||          |.:.|:.     .|::|:..|..|...|.:|.       |...||.
  Rat     9 VGCGL-GPGAVAMAVALEDGAEPPVL-----TTHLKKVENHITEAQRFSHLPKRSAVDIEFVELS 67

  Fly   468 KKFQTS----KR--DTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDS---GKIIV 523
            ...:..    ||  .||:. .|:.....:|:..::|.:||||:|.||::.|.  ::|   |:|:|
  Rat    68 YSVREGPCWRKRGYKTLLK-CLSGKFCRRELIGIMGPSGAGKSTFMNILAGY--RESGMKGQILV 129

  Fly   524 CSE-RDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDA-RDWADEKLKKLGLSDKR 586
            ... ||:.::|.:..:..|..:.:.::|..:.:...|.|:.:.:.:. ::...|.|..|||....
  Rat   130 NGRPRDLRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCS 194

  Fly   587 NEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYM 651
            :.....||||.::||::.:.:..|..::..|||:||||..|..::..::.:|......::.|.:.
  Rat   195 HTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAHGGRTVICTIHQ 259

  Fly   652 EEAEV--LGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEIMEIIHHFVPTAR 714
            ..|::  :.|.:.||:.|:....|                               ::.:.:|..:
  Rat   260 PSAKLFEMFDKLYILSQGQCIFKG-------------------------------VVTNLIPYLK 293

  Fly   715 VLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGE-----QDQ 774
            .|.:..||        |.|   ...:.:|..|.|.|         .|..:..|....     .::
  Rat   294 GLGLHCPT--------YHN---PADFIIEVASGEYG---------DLNPMLFRAVQNGLCTMAEK 338

  Fly   775 VDTPDGSRNDAPLLAHYKRLQDHPPHRGLFQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGA 839
            ..:|:  :|:.|  ||....   ||.....:        ..||.::    ||...||.|...|.:
  Rat   339 KSSPE--KNEVP--AHCPTC---PPELDPIE--------SHTFATS----TLTQFCILFRRTFLS 384

  Fly   840 IL----VMHA--MSLVENEEALPLKLSQMGSGVIYVHNPTG----------HHAHLEQQLRQQIE 888
            ||    :.|.  ||.|.....:.|....:|.....|.|.||          ..|.:...|...:|
  Rat   385 ILRDTVLTHLRFMSHVLIGVLIGLLYLHIGDDASKVFNNTGFLFFSMLFLMFAALMPTVLTFPLE 449

  Fly   889 LNGITAKTMHLRGSNDVKNESLDLQRDNLADFLEQVI------GIIDMYGGGRGTSDTPTIEIFY 947
            :.....:  ||.....:|...|   ...:||...||:      .|:....|  ..::|....:|.
  Rat   450 MAVFMRE--HLNYWYSLKAYYL---AKTMADVPFQVVCPVVYCSIVYWMTG--QPAETSRFLLFS 507

  Fly   948 SGNRYHSSVELINLVDSAMLKLGRPESEIDTTYVPIRRFVSDISPSRLEYYAVIVPIGMFFFMFY 1012
            :     .|:....:..|..|.:|..     :|.:.:..||..::         .:|:  ..|..:
  Rat   508 A-----LSIATALVAQSLGLLIGAA-----STSLQVATFVGPVT---------AIPV--LLFSGF 551

  Fly  1013 FISLPFREYANGFKQLQTMSRFTYW--FAHFTFDMLILI--------FVC-----------VALF 1056
            |:|         ||.:.|..:::.:  :..:.|:.|||.        ..|           :.|.
  Rat   552 FVS---------FKTIPTYLQWSSYLSYVRYGFEGLILTIYGMERGHLTCLEDHCPFRDPQIILH 607

  Fly  1057 SLQSLMMPSELYTTAELKVIVLSIFFYG---CSYLPILY 1092
            .|.  :..::||    :..:||.|||..   .:||.:.|
  Rat   608 ELD--VEEAKLY----MDFLVLGIFFLALRLLAYLVLRY 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468
		CcmA	460..767	CDD:224054	68/326 (21%)
		ABC_subfamily_A	461..679	CDD:213230	57/230 (25%)
		ABC2_membrane_3	<937..1117	CDD:289468	33/180 (18%)
		ABC_subfamily_A	1255..1479	CDD:213230
		drrA	1262..1573	CDD:130256
Abcg4	NP_001100286.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000