DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and Abca16

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	XP_038957107.1	Gene:	Abca16 / 293444	RGDID:	1563534	Length:	1680	Species:	Rattus norvegicus

Alignment Length:	1790	Identity:	435/1790 - (24%)
Similarity:	769/1790 - (42%)	Gaps:	333/1790 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VFLRKNLLYLQRNLLP-------------LLLICSGFAGV-LTAYLHWSVKPVLHQINQFEAKNE 61
            |.|.||....:|.:|.             :|||......: :....|::.:|:....:..:...|
  Rat    11 VLLWKNFTLKKRQVLSTVMEVLAALLFVIMLLIFRALTDMNIAGPYHFTPQPIATMPSFIKDAQE 75

  Fly    62 MVLRELYFPGNELDYIYYSPISPNVEDIMDLLRVDLGIIPERLRPNNNSFEMQLEMEQQCRGSCF 126
            ..|  :|.| :|:|.     ::..:||:...|.:.:.:   |..|:...||..:..:...:....
  Rat    76 WEL--IYIP-SEIDV-----VTEIIEDVKRNLNITIKV---RGFPSEVEFEEYILFDYTSQKVLA 129

  Fly   127 AIDFHRVPNRGSDRKFRYSLSSNQMRISPRKRFVNDEEI-------------------------- 165
            ||.|        |..|:.......:::....|||..:..
  Rat   130 AIVF--------DCDFKNKTDPLPLQVKYHLRFVGAQRTIWWPDKIGWKTRLLFPNHPSLKPRNP 186

  Fly   166 -YHQIDDDDYIRSGFLSLQHILDKQYMKYQE--LGKD-FEVVVSSMPNMEVISMDSHRLTYFGTL 226
             |.......||:.|||::||.:||..|.|.|  .||: ||.:.:.:......|....:|.:..:.
  Rat   187 NYLDGGSPGYIKEGFLAVQHAVDKSIMLYHESRAGKELFENIDTLVQRFPYPSHPQDKLLWISSP 251

  Fly   227 CSILFNVVLLSSFVV----PFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYTLLMIFVLVV 287
            ...|..:::.||.|:    ..|.||:..|||:..::...:::..:.:|...|..|..::..:.::
  Rat   252 FIPLMFILMFSSIVLSIMRSIVFEKEKRLKEYQLIMGLRNWIIWMGYFFTFFPLYVAIIFLICIL 316

  Fly   288 AYL---------YKALGSICFAYVAVLFLLYILSTMSYAYLISICFHSV-FYAKIGGLAMLIIPY 342
            .::         |    |.| :::.|....|.::::.:|:::|..|... ..|..|.|......:
  Rat   317 LFIQIVEEPILRY----SDC-SFIFVFLTCYAIASICFAFMVSTFFSKTRLAASAGNLLFFASFF 376

  Fly   343 AFSFVRSW-----ATSLAFVCFSTNTFLE-GLDI---------------FQTFSNKRKNREFGAV 386
            .::|:..:     .|:....|.|.|..|. |::|               ..|.:|...|..||
  Rat   377 PYNFISEYYGMLDLTTKITACLSANVALALGINILIKLEIQEIGVKWDNLWTPANLEDNLNFG-- 439

  Fly   387 DVFRVIKSNSSTMFSVYV--VLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQR- 448
                            |:  :|:..:|||:::..|:..||||..|:.:|.:||:....:..:.:
  Rat   440 ----------------YMLGMLLLDAFLYSLVTWYVEAVFPGQCGVPQPWYFFIMRSYWFGKPKI 488

  Fly   449 --------------NEYTTTPRGTHA-IIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGH 498
                          |.|...|....| |.|..|.|:|:|..    ..:||::.|...::||||||
  Rat   489 RKIGEEAKSIPVVHNCYEAEPSNLEAGIQIKHLHKEFKTKP----AINNLSLNIYEGQVTVLLGH 549

  Fly   499 NGAGKTTMMNMIMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQ 560
            |||||||.::::.|......|:..:..   ..::|..|..:||||||.:....:|..:||.|:..
  Rat   550 NGAGKTTTLSVLTGRFAATRGEAYINGYNISDNMAEIRKDLGFCPQHDLLFDDLTLSEHLFFYCM 614

  Fly   561 LRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDI 625
            ::|..::......:..|....|.:..:....::|||::|:||:.:|:.|.:|:|||||||||:|.
  Rat   615 IKGHPQNINCVEINRMLSVFNLQENYHTLSGSVSGGVRRKLSIILALMGGSKVVILDEPSSGMDP 679

  Fly   626 NSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKL 690
            .|||..||||.:.::.:.:|:|||||:||:||||.|.|:..|.|...||.:.||:..|.||.:.|
  Rat   680 MSRRATWDILQHYKQNRTILLTTHYMDEADVLGDRIAIMVRGTLHCCGSSVFLKQIYGAGYHIVL 744

  Fly   691 EINDFTSREVEIMEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTIS 755
            |...:...: .|:.:|...||.:.:.|.:...:...||..|.:.|..:...||...|.|||....
  Rat   745 EKEPYCDVD-NIIAMIQQHVPGSMLENDIGNELSFILPKKYVSRFETLFTELEMRQKALGIANFG 808

  Fly   756 MTDTSLEDVFL---RCAGEQDQVDTPDGSRNDAPLLAHYKRL-QDH------------------- 797
            .:.|::|:|||   :.|..|..:.|..      |....||:: ||.
  Rat   809 ASITTMEEVFLKVNKLAAPQRSIQTIQ------PYYLTYKKMRQDEQQNVNILRNYNKPIFPYLR 867

  Fly   798 -----------PPHRGLFQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGAILVMHAMSLVEN 851
                       |.:|   |.:.::|.|:..||...|....:.:.:..|.....:|.:|   |.:|
  Rat   868 EIATVKFNTGVPLYR---QQFYSMFIKRALFIGRNWKLMFLQIIVVLVVTTYLLLSLH---LDDN 926

  Fly   852 EEALP---LKLSQMGSGVIYVHNPTGHHAHLEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQ 913
            :  :|   |.||..|..:: .::.:|:         ..:.||.|....:.|:.    ||:||...
  Rat   927 D--IPERELNLSHYGKTIV-PYSISGN---------SDLALNLIKNLKIFLKS----KNQSLKKI 975

  Fly   914 RDNLADFLEQ--------VIGIIDMYGGGRGTSDTPTIEIFYSGNRYHSSVELINLVDSAM-LKL 969
            :.::.:::.:        :|.:     ..:...:...:.||::...|||....::::|:.: :.|
  Rat   976 KGDMNNYILENKDCRTFCIIAL-----SIKVERNKTVLTIFFNNEAYHSPAISLSILDNILFMTL 1035

  Fly   970 GRPESEIDTTY---VPIRRFVSDISP-SRLEY-----YAVIVPIGMFFFMFYFISLPFREYANGF 1025
            ...::.| |.:   .|:..:.|:..| :.|:.     :.:.|.:|.|...      ...|..:..
  Rat  1036 SGRDASI-TAFNKPQPLPHYGSNTVPVNGLQIVQCLAFGISVVVGSFSIQ------TVTERISQA 1093

  Fly  1026 KQLQTMSR---FTYWFAHFTFDMLILIFVCVALF------SLQSLMMPSELYTTAELKVIVLSIF 1081
            |.:|.::.   .|||.:....|::...|.|..|.      .|::.::......|      :|...
  Rat  1094 KHIQFLTGVCVLTYWLSALLCDLIFFFFACCVLLGIFRFCQLEAFVVHYNFLDT------ILIFM 1152

  Fly  1082 FYGCSYLPILY----------------ALGNNFKSISTISTY-----------LLLMLIVSAIAP 1119
            .||...:|:.|                .|.|.|.::.:|..|           .|:.:::..|..
  Rat  1153 LYGWCVVPLTYLGSFLFNSSTAAYIKITLFNYFSTMFSIIIYTIVQFYGEDFPALIHILIKTILM 1217

  Fly  1120 LITSSNAAAMKLHETKIAFLCFLPDFNLN----HQFRII----NENFITRRHPALIKGLISQDTF 1176
            .:.|.| .||.:.:       :..|:.:.    .:||.|    :|.||...    :.| ..:...
  Rat  1218 ALPSYN-LAMSISK-------YFDDYEVKRLCAREFRSIYMDCSEPFIQNN----VYG-FGEHGI 1269

  Fly  1177 FAYATAVGVMVMAFFTIVLE----HKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDDCAR 1237
            ..:...:..|.:.|..::|.    ...|:..:...:..:.:.:.:....|....:...:.|:..|
  Rat  1270 GKFLITLATMGLVFLLLLLSLESVSSSLKNFVFRNVLFYFYNKIRKGRHGVHSKSTKEDEDEDIR 1334

  Fly  1238 EEKRVTDLIKDPLNDHSLIVHNLRKRYGD---KLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQM 1299
            :|||....:...|.:..|:::.:.|.|..   ..||..:|....:.|||||||:||||||:||:|
  Rat  1335 KEKRKVFTLLLRLQNTPLVLNEVTKIYFKCPVVKAVKNISLVVRKSECFGLLGLNGAGKTTTFKM 1399

  Fly  1300 IAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDG 1364
            :.....:..|...|.|..:.::..|.|...|||||.:::...||..:.|...|.|.|:..:
  Rat  1400 LTGEETITSGIAFIDGNSVTKNPRKIRSRIGYCPQSESVLNHMTGRESLIMYARLWGVPEQ---- 1460

  Fly  1365 PASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRF 1429
              ...|:|:.:|..:||.......:..||.|:||:|..|:|::|..::|.||||:||:||:::..
  Rat  1461 --DINEYVEAFLHSVHLEPIADQIIYTYSAGSKRRLSTAIALMGKSSVVFLDEPSTGMDPVAQHL 1523

  Fly  1430 LWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRLSG----FTIKLKM 1490
            ||..:.......:.:::|||.|:|||.||:|||||..|||.||.....:::..|    .|:|:.:
  Rat  1524 LWDTVTWVCKTGKAIIITSHRMEECEALCSRLAIMVKGKFTCLGTPQHVRKRFGQVYTLTVKINI 1588

  Fly  1491 KADTETEMNVSTITGTLKSEFPG-LELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSA 1554
            ..|.|   .|......:||.||| ::.:|.| ||:.|::.:.|  :.|..||:|.||   .::..
  Rat  1589 AKDEE---KVKEFKDFIKSTFPGNIKFQEFH-GTIGYYIPSTE--ICWGKVFEILEE---AKVLF 1644

  Fly  1555 LVADYSVNECTLEDIFLKFEREAKSQSTSRQTSVQ 1589
            .:.||||.:.|||.|||.|....| ..|.|:..:|
  Rat  1645 KLEDYSVKQVTLEQIFLTFANTDK-MKTYREIKLQ 1678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	26/151 (17%)
		CcmA	460..767	CDD:224054	111/313 (35%)
		ABC_subfamily_A	461..679	CDD:213230	83/220 (38%)
		ABC2_membrane_3	<937..1117	CDD:289468	39/225 (17%)
		ABC_subfamily_A	1255..1479	CDD:213230	82/226 (36%)
		drrA	1262..1573	CDD:130256	114/318 (36%)
Abca16	XP_038957107.1	rim_protein	<163..1664	CDD:130324	398/1602 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342270
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860