DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and Abca17

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001026807.1	Gene:	Abca17 / 287112	RGDID:	1560494	Length:	1773	Species:	Rattus norvegicus

Alignment Length:	1741	Identity:	469/1741 - (26%)
Similarity:	791/1741 - (45%)	Gaps:	247/1741 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FFVFLRKNLLYLQRNLLPLLLICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVLRELYFPG-- 71
            |.:..||.|:.:...|:|:|.      ..:..||..:..| .::.|......::.|..:||..
  Rat    15 FVLKKRKTLVTVLETLMPVLF------SAIVLYLRLNSMP-RNKANTNYPAVDVSLLPVYFHNYP 72

  Fly    72 --NELDYIYYSPISPNVEDIMDLLRVDLGIIPERLR-PNNNSFEMQLEMEQQCRGSCFAIDFHRV 133
              ::...:|....|..::.:.:::.....:..|.|. |:.:.||..:..:.:.......|.||..
  Rat    73 LKSKFQLVYIPSKSETLKAVTEVVEQTFAVDFEVLGFPSVSLFENYIIKDPKSFYVLVGIVFHHD 137

  Fly   134 PNRGS---------DRKFRYSLSSNQMRISPRKRFVNDEEI---------------------YHQ 168
            .|..:         |.:|.|...::   |||.:.....|:|                     |..
  Rat   138 FNSSNEPLPLVVKYDLRFSYVQRNS---ISPPRHLFFQEDIEGWCTAFLYPPNLSQAPREFSYAD 199

  Fly   169 IDDDDYIRSGFLSLQHILDKQYMKYQ------ELGKDFEVVVSSMPNMEVISMDSHRLTYFGTLC 227
            .....|.:.|||::||.:||..|.:.      ::.|:.:|.|...|:      .||....|..:.
  Rat   200 GGHPGYNKEGFLAIQHAVDKAIMLHHAPKAALDMFKNLQVSVQRFPS------GSHIQDPFLVIL 258

  Fly   228 SILFNVVLLSSFVVPFVE---------EKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYTLLMIF 283
            ...|.::|:.||:.  ||         ||:...||::.|:...::|:.:.:| |.|....|:.:.
  Rat   259 QNEFPLLLMLSFIC--VELIITNSILLEKERKQKEYMYLMGLENWLHWVAWF-ITFFLSALVTVS 320

  Fly   284 VLVVAYLYKALGSICF-----AYVAVLFLLYILSTMSYAYLISICFHSVFYAK-IGGLAMLI--I 340
            .:.|.:..|..|...|     ..:.:..:.:.::|:.:|:::|..|....... |||:....  :
  Rat   321 GMTVLFCTKMNGVAVFRNSNPTLIFIFLMCFAIATIFFAFMMSTFFQRAHVGTVIGGIVFFFTYL 385

  Fly   341 PY---AFSF-VRSWATSLAFVCFSTNTFLEG---LDIFQTFSNKRKNREFGAVDVFRVIKSNSST 398
            ||   .||: .|:::..:....||......|   :.:|:......:.|..|:|       ....:
  Rat   386 PYMYITFSYHQRTYSQKILSCLFSNVAMAMGVRFISLFEAEGTGIQWRNMGSV-------WGDFS 443

  Fly   399 MFSVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFL--------------------DPKTY 443
            ...|.|:|:..||||.::...:..:||...|:.:..:.|.                    ||:
  Rat   444 FTQVLVMLLLDSFLYCLVAFLVESLFPRKIGMPKSWYIFAKCPLWRKKSFPVIPPLLVIGDPE-- 506

  Fly   444 MKRQRNEYTTTPRGTH--AIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTM 506
             |..:.::.......|  ||.|..|.|.|.|.:...:...:|:|.:...:||||||||||||||:
  Rat   507 -KTSKGDFLQDEPAGHINAIEIQHLYKVFYTGRSKCIAVKDLSMNLYKGQITVLLGHNGAGKTTV 570

  Fly   507 MNMIMGLVPKDSGKIIV--CS-ERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSD 568
            .:::.||:|...|...:  |. .:|:...|..:|:||||.:.....|...||.|:.||:|....|
  Rat   571 CSVLTGLIPPSKGHAYIHGCEISKDMVRIRKNVGWCPQHDILFDNFTVTDHLYFYGQLKGLSHQD 635

  Fly   569 ARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWD 633
            ..:..:|.|..|||.||||...|.|||||||:|::|||:...:|::|||||:||:|.:|||.:||
  Rat   636 CHEKIEEMLHTLGLEDKRNSRSKFLSGGMKRKLAIGIALIAGSKVLILDEPTSGMDSSSRRAIWD 700

  Fly   634 ILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSR 698
            :|...:.::.||:|||:|:||::|||.|.|||.|:||..|:|..||:|.|.||.:.:........
  Rat   701 LLQQQKGDRTVLLTTHFMDEADLLGDRIAILAKGELQCCGTPSFLKQKYGAGYYMTIIKTPLCDT 765

  Fly   699 EVEIMEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLED 763
            | ::.::|:|.:|.|.:.:.:...:...||......|..:...||....||||.|...:.|::|:
  Rat   766 E-KLAKVIYHHIPNAILESRIGEEMIFTLPKKAMPRFEALFADLEQRQTELGISTFGASVTTMEE 829

  Fly   764 VFLRCAGEQDQVDTPDGSRN----DAPLLAHYKRLQDHPP------HRGLFQL------------ 806
            ||:|..      ...|.|.|    ..|.|.|..|....|.      |..:|.|
  Rat   830 VFIRVC------KLADPSTNVLTEKRPSLRHLPRNHRVPVDRIKCLHSRIFSLSSDQPIRLNTGF 888

  Fly   807 ------WMAVFYKKWTFISNEWLYTL-IMLCIPFVCVFGAILVMHAMSL----VENEEALPLKLS 860
                  :.|:..||..|....|:..| :.:.:|.|      ::|.::|.    :...:.:||:|:
  Rat   889 SLLCQQFYAMLLKKVAFSRRNWMLVLSVQILLPLV------IIMLSLSFFNFKLRKLDNVPLELT 947

  Fly   861 QMGSGVIYVHNPTGHHAHLEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQRDNLADFLEQVI 925
            ....|...|......::.|:.||........:.|..:.||....|:|..|...::...||.:..:
  Rat   948 LQTYGQTIVPFFIAENSRLDPQLSDNFVKMLVAAGQVPLRIQGSVENFLLKKAKEAPEDFDKLYV 1012

  Fly   926 GIIDMYGGGRGTSDTPTIEIFYSGNRYHSSVELINLVDSAMLK-LGRPESEIDTTYVPIRRFVSD 989
                :.......:|..|::..::...|||....:.|||:.:.| |....:.|.||..|..:...:
  Rat  1013 ----VAASFEDVNDHTTVKALFNNQAYHSPSLALALVDNVLFKLLSGANASITTTNYPQPQTAME 1073

  Fly   990 ISPSRL-----EYYAVIVPIGMFFFMFYFISLPFREYANGFKQLQT--------MSRFTYWFAHF 1041
            :|.:.|     .:|.|:    .|.|...|:|..|.....|.|.:::        :|...:|.:..
  Rat  1074 LSETILYQGPKGHYLVV----NFLFGIAFLSSSFSILTVGEKSIKSKNLQFLSGVSMAAFWLSAL 1134

  Fly  1042 TFDMLILIFVCVALFSLQSLMMPSELYTTAE-LKVIVLSIFFYGCSYLPILYALGNNFKSISTIS 1105
            .:| ||...|...|..|.......|.:...: :..:||.:..||.:.:|::|.:..:||:..:..
  Rat  1135 LWD-LISFLVPTLLLVLVFFWYKEEAFAHPQSIPAVVLIMMLYGWAIIPLVYTVSFSFKTPGSGC 1198

  Fly  1106 TYLLLMLIVSAIAPLITSSNAAAMKLHETKIA------FLCF------LPDFNLNHQFRIINENF 1158
            ..|:.||...:|:|::..:..:.:.|..|:::      ||.|      :...||.:.|.|  :.|
  Rat  1199 VKLVAMLTFLSISPVVLVTVTSEIDLGYTELSDTLDHIFLIFPGHCLGMAFSNLYYNFEI--KKF 1261

  Fly  1159 ITRRHPA------LIKGLISQDTFFA--------YATAVGVMVMAFFTIVLEHK-----YLRRRI 1204
            ...::.:      :::|.:.|...:|        |.||:.::...:.|::...:     .|:.|:
  Rat  1262 CNAKNLSDIDCNDVLEGYVVQKNIYAWESLGIGKYLTALAILGPVYITLLFLTEANAFCALKARL 1326

  Fly  1205 HDGIWEWAFQRKKYNSTGTLPSTPISEIDDCAREEKRVTDLIKDPLNDHSLIVHNLRKRYGDK-- 1267
             .|.:.....|...|.||       :|.:|...|.:.:...:...:....|:|..|.|.|.:|
  Rat  1327 -SGFFCKQKLRMLLNVTG-------AEDEDVLEEAENIKYHLDTLIKKSPLVVKELSKVYKEKVP 1383

  Fly  1268 -LAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGY 1331
             |||:.|||...:.|||||||:|||||||.|.|:....|:..|...:||.:||....|.:::.||
  Rat  1384 LLAVNKVSFVVKEKECFGLLGLNGAGKTSIFNMLTREQPITSGDAFVKGFNIRTDMAKVQQWIGY 1448

  Fly  1332 CPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGT 1396
            ||::|||..|||..:.|...|.:||:..      ...|..|...||.:.:..|....|:.||.|.
  Rat  1449 CPEFDALLNFMTGREMLVMHARIRGIPE------CHIKTCVDMILENLLMCVYADKLVKTYSDGN 1507

  Fly  1397 KRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRL 1461
            ||.|..|:|::|.|.::|||||:||:||::||.:|..:...:...:|:|:|||||:|||.||.||
  Rat  1508 KRVLSTAIALLGEPTVILLDEPSTGMDPVARRLVWDAVGRVRESGKTIVITSHSMEECEALCTRL 1572

  Fly  1462 AIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTL 1524
            |||..|:||||.:...||..  ||::::.|::...:.:| :......:...|||..|.:.|...:
  Rat  1573 AIMVQGQFKCLGSPQHLKSRFGSGYSLQAKVRRKWQQQM-LEEFKAFVDLTFPGSSLEDEHQSMV 1636

  Fly  1525 TYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFER 1575
            .|::..|.  :.|:.||.|.|:...|   .::.|||:::.:||||||.|.|
  Rat  1637 QYYLPGQN--LSWAKVFGIMEQAKKD---YVLEDYSISQLSLEDIFLSFTR 1682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	34/158 (22%)
		CcmA	460..767	CDD:224054	124/309 (40%)
		ABC_subfamily_A	461..679	CDD:213230	98/220 (45%)
		ABC2_membrane_3	<937..1117	CDD:289468	45/194 (23%)
		ABC_subfamily_A	1255..1479	CDD:213230	99/226 (44%)
		drrA	1262..1573	CDD:130256	124/315 (39%)
Abca17	NP_001026807.1	ABC2_membrane_3	<262..464	CDD:289468	46/211 (22%)
		ABC_subfamily_A	525..746	CDD:213230	98/220 (45%)
		drrA	543..834	CDD:130256	117/291 (40%)
		ABC2_membrane_3	913..1255	CDD:289468	75/356 (21%)
		CcmA	1369..1682	CDD:224054	128/324 (40%)
		ABC_subfamily_A	1369..1590	CDD:213230	99/226 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1690..1773
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342202
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760