DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and Abca3

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001034670.1	Gene:	Abca3 / 27410	MGIID:	1351617	Length:	1704	Species:	Mus musculus

Alignment Length:	1780	Identity:	510/1780 - (28%)
Similarity:	801/1780 - (45%)	Gaps:	327/1780 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RKNLLYLQRNLLPLLLICSGFAGVL---------------TAYLHWSVKPVLHQINQFEAKNEMV 63
            ||.|:.:....||||     |:|:|               |.|...|::.:
Mouse    20 RKVLVTVLELFLPLL-----FSGILIWLRLKIQSENVPNATVYPDQSIQEL-------------- 65

  Fly    64 LRELYF----PGNELDYIYYSPISPNVEDIMDLLRVDLGIIPERLRPNNNSFEMQLEMEQQCRGS 124
              .|:|    ||...:..|....|.....|.:.::.:..|   ::|.:..|.|...|
Mouse    66 --PLFFSFPPPGGTWELAYVPSHSDAARTITETVKREFMI---KMRVHGFSSEKDFE-------- 117

  Fly   125 CFAIDFHRVPNRGSD----RKFRYSLSSNQ----------MRISPRKR----------FVNDEEI 165
                |:.|..|..|.    ..|.:|.:.:|          :|.|..:|          |:.:.|.
Mouse   118 ----DYIRYDNHSSSVLAAVVFEHSFNHSQDPLPLAVKYHLRFSYTRRNYMWTQTGNIFLKETEG 178

  Fly   166 YHQID-------------------DDDYIRSGFLSLQHILDKQYMKY------QELGKDFEVVVS 205
            :|...                   :..|||.|||::||.:||..|:|      |:|.:...|:..
Mouse   179 WHTTSLFPLFPSPGPREPSSPDGGEPGYIREGFLAMQHAVDKAIMRYHANTSAQQLFQKLMVITK 243

  Fly   206 SMPNMEVISMDSHRLTYFGTLCSILFN--VVLLSSF-------VVPFVEEKQNGLKEFLNLVTPM 261
            ..|....|| |..       |.:|.:.  ::|:.||       :...|:||:..|||::.::...
Mouse   244 RFPFPPYIS-DPF-------LIAIQYQLPLLLMLSFTYTSLTIIRAVVQEKEKKLKEYMRMMGLN 300

  Fly   262 SFLNGLTFFLIRFVCYTLLMIFVLV---------VAYLYKALGSICFAYVAVLFLLYILSTMSYA 317
            |:|:...:||:.|:.:.:::.|:.:         :|.|..:..|:..|::    |.:.:|::|::
Mouse   301 SWLHWSAWFLMFFLFFLIVVSFMTLLFCVKVKKDIAVLSNSDPSLVLAFL----LCFAISSISFS 361

  Fly   318 YLISICFHSV-FYAKIGGLAMLI--IPYAFSFVR-SWAT--SLAFVCFSTNTFLE-GLDIFQTFS 375
            :::|..|... ..|.:||.....  .||.|...| :|.|  .....|..:|..:. |..:...|.
Mouse   362 FMVSTFFSKANIAAAVGGFLYFFTYTPYFFVAPRYNWMTLSQKLLSCLLSNVAMAMGAQLIGKFE 426

  Fly   376 NKRKNREFGAVDVFRVIKSNSSTMF-SVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFL- 438
            .|....::.  |:...:..:.:..| .|..:|:..|.||.::..|:..||||..|:.:|..|||
Mouse   427 AKGTGIQWR--DLLNPVNVDDNFCFGQVLGMLLLDSALYGLVTWYVEAVFPGQFGVPQPWHFFLM 489

  Fly   439 ------DPKTYM----------KRQRNEY-TTTPRGTHA-IIITELCKKFQTSKRDTLISDNLNM 485
                  :|:|.:          |..|||| ...|....| |.|..|.|.||...:|.:...:|.:
Mouse   490 PSYWCGNPRTVVGKEEEGSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFQVGNKDKMGIRDLTL 554

  Fly   486 TINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMS 547
            .:...:||||||||||||||.|:::.||.|..||...:..   .:|:|..|..:|.||||.|...
Mouse   555 NLYEGQITVLLGHNGAGKTTTMSLLTGLFPPTSGHAYIHGYEISQDMAQIRKSLGLCPQHDVLFD 619

  Fly   548 YMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTK 612
            .:|..:||.|:|||:|.......:...:.|..|.|.|||:...|.|||||||:||:|||:...:|
Mouse   620 NLTVAEHLYFYAQLKGLSLQKCPEEVKQMLHILSLEDKRDLRSKFLSGGMKRKLSIGIALIAGSK 684

  Fly   613 IVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLE 677
            :::||||:||:|..|||.:||:|...:.::.||:|||:|:||::|||.|.|||.|:||..||.|.
Mouse   685 VLMLDEPTSGMDAVSRRAIWDLLQQQKSDRTVLLTTHFMDEADLLGDRIAILAKGELQCCGSSLF 749

  Fly   678 LKRKSGIGYRLKLEINDFTSREVEIMEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRL 742
            ||:|.|.||.:.|......:.| .|.:::||.||.|.:.:.....:...||....:.|..:..:|
Mouse   750 LKQKYGAGYHMTLVKEPHCNPE-GISQLVHHHVPNAMLESHAGAELSFILPKESTHRFESLFAKL 813

  Fly   743 ETESKELGIHTISMTDTSLEDVFLRCAGEQDQVDTP-DGSRNDAPLL--AHYKRLQD-------- 796
            |.:.|||||.:...:.|::|:||||..   ..|||. |......|.|  .|.:|..|
Mouse   814 EKKQKELGIASFGASVTTMEEVFLRVG---KLVDTSMDIQAIQLPALQYQHERRASDWALDSNLC 875

  Fly   797 --HPPHRGL---------------------FQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFG 838
              ..|..|:                     .|.| |:|.||..:...||......:.:|..|:..
Mouse   876 GVMDPTNGIGALIEEEEVLVKLNTGLALHCQQFW-AMFLKKAAYSWREWKMVAAQVLVPLTCLTL 939

  Fly   839 AILVMHAMSLVENEEALPLKLSQMGSGVIYVHNPTGHHAHLEQQLRQQIELNGITAKTMHLRGSN 903
            |:|.:|..|.:.::..|.|.|::.|..|:....|  ..:.|.|||.:.:               .
Mouse   940 ALLAIHYTSEIFDDPLLKLSLNEYGRTVVPFSVP--GTSRLAQQLSENL---------------R 987

  Fly   904 DVKNESLDLQRDNLADFLEQVIGIIDMYGGG-----------RGTSDTPTIEIFYSGNRYHSSVE 957
            |:........|:.|.|..|.::....:.|||           :...:...:...::...|||...
Mouse   988 DMLQAERQEPREVLGDLEEFLVFRASVEGGGFNERCLVATSFKDRGELTVVTALFNNQAYHSPAT 1052

  Fly   958 LINLVDSAMLKL--GRPESEIDTTYVPIRRFVSDISPSRLEY------YAVIVPIGMFFFMFYFI 1014
            .:.:||:.:.||  | |::.|:.:..|..|....::......      .|:.:.|.|.|....|.
Mouse  1053 ALAIVDNLLFKLLCG-PQASIEISNYPQPRNTLQVAKDHFNEGRKGFDIALNLLIAMAFLASTFS 1116

  Fly  1015 SLPFREYANGFKQLQTMSRF---TYWFAHFTFDML------ILIFVCVALFSLQSLMMPSELYTT 1070
            .|...|.|...|.:|.:|..   |:||:...:|::      :|:.|....|::.:......:
Mouse  1117 ILAVSERAVQAKHVQFVSGVHVATFWFSALLWDLISFLVPSLLLLVVFQAFNVHAFTRDGHM--- 1178

  Fly  1071 AELKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLLLMLIVSAIAP--LITSSNAAAMKLHE 1133
            |:|   :|.:..||.:.:|::|.:...|.:.||..|.|.:..|:|.||.  ::|.....|:||.|
Mouse  1179 ADL---LLLLMLYGWAIIPLMYLMSFFFSAASTAYTRLTIFNILSGIATFIMVTIMRIPAVKLEE 1240

  Fly  1134 ---TKIAFLCFLPDFNLNHQFRIINENFITRR---------HPALIKGLISQDTFFAYAT-AVGV 1185
               |.......||:..|........||:.|||         |......:..|::|:|::| .||.
Mouse  1241 LSRTLDHVFLVLPNHCLGMAVSNFYENYETRRYCTSSELAAHYCKKYNIQYQESFYAWSTPGVGK 1305

  Fly  1186 MVMA-------FFTI--VLEHKYL----------RRRIHDGIWEWAFQRKKYNSTGTLPSTPISE 1231
            .|.:       :.|:  ::|...|          |||     |..|   :..|.|..||     |
Mouse  1306 FVTSMAASGGIYLTLLFLIETNLLWRLRTFICAFRRR-----WTLA---ELQNRTSVLP-----E 1357

  Fly  1232 IDDCAREEKRVTDLIKDPLNDHSLIVHNLRKRYGDK---LAVDGVSFAAAQGECFGLLGVNGAGK 1293
            ..|.|.|..|:.....|.:.|..||::.|.|.|..:   ||||.:|.|..:||||||||.|||||
Mouse  1358 DQDVAEERSRILVPSLDSMLDTPLIINELSKVYDQRAPLLAVDRISLAVQKGECFGLLGFNGAGK 1422

  Fly  1294 TSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLS 1358
            |:||:|:.....:..|...:.|..|.....|.|:..|||||:|||...||..:.|...|.|||:.
Mouse  1423 TTTFKMLTGEETITSGDAFVGGYSISSDIGKVRQRMGYCPQFDALLDHMTGREMLVMYARLRGIP 1487

  Fly  1359 RRRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVD 1423
            .|..:   :|.|:.   |..:.|..:....|:.||||.||||...:|:||.||::.||||:||:|
Mouse  1488 ERLIN---ACVENT---LRGLLLEPHANKLVKTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMD 1546

  Fly  1424 PISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTI 1486
            |::||.||..:...:...:.:|:|||||:|||.||.|||||..|:||||.:...||..  ||:::
Mouse  1547 PVARRLLWDTVARARESGKAIVITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSL 1611

  Fly  1487 KLKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKI---AEEYL 1548
            :.|::::.:.:. :......:...|||..|.:.|...:.|.:...:  :.|:.||.|   |:|..
Mouse  1612 QAKVRSEGKQDA-LEEFKAFVDLTFPGSILEDEHQDMVHYHLPGCD--LSWAKVFGILEKAKEKY 1673

  Fly  1549 GDRLSALVADYSVNECTLEDIFLKF 1573
            |      |.||||::.:||.:||.|
Mouse  1674 G------VDDYSVSQISLEQVFLSF 1692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	35/158 (22%)
		CcmA	460..767	CDD:224054	128/310 (41%)
		ABC_subfamily_A	461..679	CDD:213230	99/220 (45%)
		ABC2_membrane_3	<937..1117	CDD:289468	44/196 (22%)
		ABC_subfamily_A	1255..1479	CDD:213230	100/226 (44%)
		drrA	1262..1573	CDD:130256	124/318 (39%)
Abca3	NP_001034670.1	rim_protein	1..>43	CDD:130324	10/27 (37%)
Abca3	NP_001034670.1	rim_protein	<206..1699	CDD:130324	472/1558 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838420
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760