Protein Alignment Eato and Abca8b

DIOPT Version :9

• Sequence 1: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: NP_038879.2
• Gene: Abca8b / 27404
• MGIID: 1351668
• Length: 1620
• Species: Mus musculus
• Alignment Length: 1760
• Identity: 419/1760 - (23%)
• Similarity: 734/1760 - (41%)
• Gaps: 376/1760 - (21%)

  Fly    13 LRKNLL---YLQRNLL-----PLLLICSGFAGVLTAYLHW----------SVKPV--LHQINQFE 57
            |:||||   .|:|..|     .|||:         .:|:|          |..|.  |.:::.|.
Mouse    16 LQKNLLKKWRLKRESLMEWVSSLLLL---------LFLYWYPHGHGATDLSSVPTKDLGRVDSFR 71

  Fly    58 AKNEMVLRELYFPGNELDYIYYSPISPNVEDIMDLLRVD--------LGIIPERLRPNNNSFEMQ 114
            ....|              |.|:|::...:.||:.:...        ||::.|     .|..|:
Mouse    72 QSGFM--------------IGYTPVTSMTQQIMEKVAATPFMADKKVLGLLDE-----ENIKEL- 116

  Fly   115 LEMEQQCRGSCFAIDFHRVPNRGSDRKFRYSLSSNQMRISPRKRFVND-----EEIYHQID--DD 172
                .:.......:.|       || .|.|.|.....:..|..|.:.|     :.:|..::  ..
Mouse   117 ----TESHAEIIRVIF-------SD-TFSYHLKFQFDQRIPTSRELRDHNAHCDGLYEDVNCLIA 169

  Fly   173 DYIRSGFLSLQHILDKQYMK-------YQEL----GKDFEVVVSSMPNMEVISMDSHRLTYFGTL 226
            .:.:.||::||..::...::       .:||    ||..:  :......|.|..|     :|...
Mouse   170 IFWKEGFVALQAAINAAIIETTTNHSVMEELLSVSGKFMK--IHPFVRQEGILTD-----FFIFT 227

  Fly   227 CSILFN-VVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLN-GLTFFLIRFVCYTLLMIFVLVVAY 289
            |.|.|: :....|..|....::..||...:.|..|..:|: ||.:  ..||....|.:.:::.:.
Mouse   228 CIISFSPITYYVSINVARERKRMKGLMMMMGLRDPAFWLSWGLLY--AGFVFIMALSLALVIKSV 290

  Fly   290 LYKALGSICFAYVAVLFLLYILSTMSYAYLISICFHSVFYAKIGGLAMLIIPYAFSFVRSWATSL 354
            .:..|.|  |..|..|||||.||.::.|:|:|..   |..:.:.||::.::..      .|. ||
Mouse   291 QFFILTS--FMVVFSLFLLYGLSMITLAFLMSAL---VRKSVLTGLSVFLLTI------FWG-SL 343

  Fly   355 AFVCFSTNTFLEG-----LDIFQTFSNKRKNREFGAVDVFRV---IKSN--------SSTMFSVY 403
            .|.  |...:|..     |.:|..|:     ...|...:.||   :.||        |:.:.:..
Mouse   344 GFT--SLYRYLPAPVEWTLSLFSPFA-----FTLGMAQLLRVDYDLNSNAPPDPASGSNLIIATN 401

  Fly   404 VVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRNEYT---------------- 452
            .:|||.:|||..|..|...|.|...|.:....|||....:::.::..:.
Mouse   402 FMLVFDAFLYLALMMYFEKVLPNEYGHQHSPLFFLKSSFWLQTRKPAHVILEDGIDPVPSSGDSF 466

  Fly   453 --TTP--RGTHAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGL 513
              .:|  .|..:|.|..:.|:::..........:|.:.|...:||.:|||:||||:|::|::.||
Mouse   467 EPVSPEFHGKESIRIRNISKEYKGKPNKIEALKDLTLDIYEGQITAVLGHSGAGKSTLLNILSGL 531

  Fly   514 VPKDSGKIIVCSER-----DVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWA 573
            .....|.:.:.:..     |:.:...:.|.|||.:|...::|..::|..||::||....|.....
Mouse   532 SVPTKGSVTIYNNNLSEMADLENILRIAGVCPQANVQFDFLTVRENLRLFAKIRGIPPQDVEKEV 596

  Fly   574 DEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNL 638
            ...|.:|.:.:.:|...:|||||.||:|:.||||.|:::|.:||||::|||..||..:|::|...
Mouse   597 QRVLLELEMKNIQNILAQNLSGGQKRKLTFGIAILGDSQIFLLDEPTAGLDPFSRHRVWNLLKER 661

  Fly   639 RKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEIM 703
            |.::.||.:|.:|:||::|.|....::||:|:..||.|.||:|.|:||.|.|::.:....| .|.
Mouse   662 RADRVVLFSTQFMDEADILADRKVFISNGRLKCAGSSLFLKKKWGVGYHLSLQLKEVCVPE-NIT 725

  Fly   704 EIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRC 768
            .::...:|.|::.......:...||......|.::...|:: ...|||....::.|:|.:|||:.
Mouse   726 SLVKQHIPAAKLSAEGEGKLLYTLPLETTYRFPELCQSLDS-CPGLGIENYGVSMTTLNEVFLKL 789

  Fly   769 AGEQDQVDTPD---------GSRNDAPLLAHYKR----LQDHPPHRGLFQLW----MAVFYKKWT 816
            .|:. .:|.|:         ....|...|...::    |::.....|: .||    .|:...:..
Mouse   790 EGKA-SIDEPEVDIVGEGQTERSGDTERLMEMEQTLSSLRETEKTDGM-ALWRQQTCAIAKVRLL 852

  Fly   817 FISNE--WLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLKLSQMGSGVIYVHNPTGHHAHL 879
            .:.:|  .|.:::::.:..:|.|          |.||   :..|:.|  |...:..:|..:....
Mouse   853 KLKHERKTLLSVLLILVVGICPF----------LFEN---ISTKIRQ--SSYTWELSPHDYFLAP 902

  Fly   880 EQQ----LRQQIELNGITAKTMHLRGSNDVKNESLD-----LQRDNLADFLEQVIGIIDMYGGGR 935
            .||    |.|.:.:|...|              |:|     ::|.|:|  ||     :|..|...
Mouse   903 GQQPQGMLTQLLIINKTEA--------------SIDDFIHSVERQNIA--LE-----VDASGTRD 946

  Fly   936 GTSDTPTIE--IFYSGNRYHSSVE-------------LINLVDSAMLKLGRPESEIDT---TYVP 982
            ||.| |:..  :..|||..:.|..             |::::.:.:|.:.:|.:.|.|   ||:
Mouse   947 GTDD-PSYNGALIVSGNEKNHSFSFACNTKRLNCFPVLMDILSNGLLGMVKPSARIQTDRSTYL- 1009

  Fly   983 IRRFVSDISPS----RLEYYAVIV----PIGMFFFMFYFISLPFREYAN-GFKQLQTMSRF--TY 1036
               ....|.|.    :..::.::.    |        |.......:|.| .:.||:....|  .|
Mouse  1010 ---MDETIHPLEDLWKTAFWLILTSACPP--------YIAMSSVTDYKNRAWFQLRVSGLFPSAY 1063

  Fly  1037 WFAHFTFDMLILIFVCVALFSLQSLM-----MPSELYTTAELKVIVLSIFFYGCSYLPILYAL-- 1094
            |......|:.:..||    |...|||     .|..:::.....:.:.....|..|.:.:.|.:
Mouse  1064 WVGQAMVDIPLYCFV----FLFMSLMDYLFRFPDTMFSIISHVIQIPCSVGYAISLIFLTYVISF 1124

  Fly  1095 ----GNNFKSISTISTYLLLMLIVSAIAPLITSSNAAAMKLHETKIAFLCFLPDFNLNHQFRIIN 1155
                |.....|.::|.|::.:..|:.|        ..|..:..|:...:..:|
Mouse  1125 ISRKGKKNSGIWSLSFYIITVFSVAVI--------LLAFDVDGTQYYIIFLIP------------ 1169

  Fly  1156 ENFITRRHPALIKG--LISQDTFFAYATAVGVMVMAFFTIVLEHKYLRRRIHDGIW-------EW 1211
                    |:.:.|  ::|...|.......|.::..|...::..      :|..|:       ||
Mouse  1170 --------PSTLVGCLILSLHLFIGQIFEEGQVIEPFLVFLIPF------LHVFIFIFTLRCLEW 1220

  Fly  1212 AFQRK------------KYNSTGTLPSTPISEIDDCAREEKRVTD-LIKDPLNDHSLIVHN-LRK 1262
            .|.:|            :.|.....|..|..|.:|...|..|..: |:....::..:|:.: |||
Mouse  1221 KFGKKTMRKDPIFRISPRNNDVYQNPEEPEDEDEDVQMERMRTANALVSTSFDEKPVIIASCLRK 1285

  Fly  1263 RYGD-----------KLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGA 1316
            .|..           |:|...|||...:||..||||.|||||:::.:||:.:..:..|.:.:||:
Mouse  1286 EYAGKQKHCLSKKKAKIATRNVSFCVRKGEILGLLGHNGAGKSTSLKMISGDTKVTAGQVLLKGS 1350

  Fly  1317 DIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEH----VKYWLE 1377
              ||.:..  .:.|||||.:||...:|.::.|...|.:|||.          |.|    :....:
Mouse  1351 --REGDTP--GFLGYCPQENALWPNLTVKEHLEIFAAVRGLR----------KSHAAVAITRLAD 1401

  Fly  1378 KMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKD-FQGKD 1441
            .:.|....|..|:..|.|.||||...::::|.|:::|||||:||:||..::.:||.|:. .:..|
Mouse  1402 ALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSILLLDEPSTGLDPEGQQQIWQAIRAIIKNTD 1466

  Fly  1442 RTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRLSGFTIKLKMKADTETEMNVSTITGT 1506
            |..:||:|.|.|.|.||:|:||:..|:.:|:.:|..||...|....|:||..|..:  |..:...
Mouse  1467 RGALLTTHYMAEAEALCDRVAILVSGRLRCIGSIQHLKSKFGKDYLLEMKVKTLEQ--VEPLNTE 1529

  Fly  1507 LKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFL 1571
            :...||....:|.::..:.|.:..:....|..:.||:.:.    :.:..:.:||:::.|||.:||
Mouse  1530 ILRLFPQASRQERYSSLMAYKLPVEAVQPLSQAFFKLEKV----KQTFDLEEYSLSQSTLEQVFL 1590

  Fly  1572 KFERE 1576
            :..:|
Mouse  1591 ELSKE 1595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	36/139 (26%)
		CcmA	460..767	CDD:224054	98/311 (32%)
		ABC_subfamily_A	461..679	CDD:213230	75/222 (34%)
		ABC2_membrane_3	<937..1117	CDD:289468	41/219 (19%)
		ABC_subfamily_A	1255..1479	CDD:213230	82/240 (34%)
		drrA	1262..1573	CDD:130256	101/326 (31%)
Abca8b	NP_038879.2	rim_protein	<265..1596	CDD:130324	360/1463 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.650