DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eato and Abca7

DIOPT Version :9

Sequence 1:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster
Sequence 2:NP_001334010.1 Gene:Abca7 / 27403 MGIID:1351646 Length:2167 Species:Mus musculus


Alignment Length:1990 Identity:497/1990 - (24%)
Similarity:791/1990 - (39%) Gaps:553/1990 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 CSGFAGVL----TAYLHW-SVKP-----------------VLHQINQ-FEAKNEM-VLRELYFPG 71
            ||.|.|.|    .:.|.| .:||                 ::.|:|| ||   |: :||:|:   
Mouse   264 CSEFVGTLDDHPVSRLLWRRLKPLILGKILFAPDTNFTRKLMAQVNQTFE---ELALLRDLH--- 322

  Fly    72 NEL------DYIYYSPISPNVEDIMDLLRV--------------DLGIIPERLRPNNNSF---EM 113
             ||      ....:...|.||..:..||.|              .|..|.:.|.|:...:   |.
Mouse   323 -ELWGVLGPQIFNFMNDSTNVAMLQRLLDVGGTGQRQQTPRAQKKLEAIKDFLDPSRGGYSWREA 386

  Fly   114 QLEMEQQC-----RGSCFAID-FHRVPNRGSDRKFRYSLSSNQMRISPRKR------FVNDEEIY 166
            ..:|.:..     ...|.::| ...||:       ..:|.|..:.:...:|      |::.|   
Mouse   387 HADMGRLAGILGQMMECVSLDKLEAVPS-------EEALVSRALELLGERRLWAGIVFLSPE--- 441

  Fly   167 HQIDD---------------------DD-------------------------YIRSGFLSLQHI 185
            |.:|.                     ||                         |:..||:.||.:
Mouse   442 HPLDPSELSSPALSPGHLRFKIRMDIDDVTRTNKIRDKFWDPGPSADPFMDLRYVWGGFVYLQDL 506

  Fly   186 LDKQYMKYQELGKD-FEVVVSSMPN--------MEVISMDSHRLTYFGTLCSILFNVVLLSSFVV 241
            |::..::....|.. ..:.:..||:        :.|:   |..|..|.||..| ::|.|.   |.
Mouse   507 LEQAAVRVLGGGNSRTGLYLQQMPHPCYVDDVFLRVL---SRSLPLFLTLAWI-YSVALT---VK 564

  Fly   242 PFVEEKQNGLKEFLNLVTPMSFLNGLTFFLI---RFVCYTLLMIFVLVVAYLYKALGSIC-FAYV 302
            ..|.||:..|:|.:..:.....:..|.:||.   .|:....|::.||       .||:|. :::.
Mouse   565 AVVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVL-------KLGNILPYSHP 622

  Fly   303 AVLFLL---YILSTMSYAYLISICF-HSVFYAKIGGLA--MLIIPYAFSFVRSW----------- 350
            .|:||.   :.::|::.::|:|..| .:...|..||||  .|.:||....  :|           
Mouse   623 VVIFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCV--AWRERLHLGGLLA 685

  Fly   351 ATSLAFVCFSTNTFLEGLDIFQTFSNKRKNREFG---AVDVFRVIKSNSSTMFSVYVVLVFQSFL 412
            |:.|:.|.|...  .|.|.:.:...:..:....|   |.|||        ::..|...|:..:.:
Mouse   686 ASLLSPVAFGFG--CESLALLEEQGDGAQWHNLGTGPAEDVF--------SLAQVSAFLLLDAVI 740

  Fly   413 YAMLYNYLGCVFPGPGGLKRPMFFFL---------------------DPKTYMKRQRNEYTTTPR 456
            |.:...||..|.||..|:..|..|..                     |||..::.       .|.
Mouse   741 YGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGPPKSSVLAPAPQDPKVLVEE-------PPL 798

  Fly   457 G-THAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGK 520
            | ...:.|..|.|.|:...:..|  ..||:......||..||||||||||.::::.||.|..||.
Mouse   799 GLVPGVSIRGLKKHFRGCPQPAL--QGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGS 861

  Fly   521 IIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGL 582
            ..:..   :.::|:.|..:|.|||::|....:|..:|:.|:.:|:|...:......:..::.:||
Mouse   862 ASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAMGPERERLIRDVGL 926

  Fly   583 SDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVT 647
            :.||:...::|||||:|:||:.||..|.:::||:|||::|:|..|||.:|::||..|:.:.::::
Mouse   927 TLKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREGRTLILS 991

  Fly   648 THYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKL---------------------- 690
            ||:::|||:|||.:.::|.|.|...||||.|:|..|.||.|.|                      
Mouse   992 THHLDEAELLGDRVAMVAGGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDAKGDSEDPRRE 1056

  Fly   691 -------EIND---------------------FTSREVEIMEIIHHFVPTARVLNVVNPTVYICL 727
                   ..:|                     .|.....|:|::...||.|:::..:...:.:.|
Mouse  1057 KKSDGNGRTSDTAFTRGTSDKSNQAPAPGAVPITPSTARILELVQQHVPGAQLVEDLPHELLLVL 1121

  Fly   728 PY--AYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQVDTPDGSRNDAPLLAH 790
            ||  |....||.:...|:.:.:.||:....::||:||::||:.      |:.......|:....|
Mouse  1122 PYAGALDGSFAMVFQELDQQLELLGLTGYGISDTNLEEIFLKV------VEDAHREGGDSRPQLH 1180

  Fly   791 YKRLQDHPP----------------------HRGL------FQLW-------MAVFYKKWTFI-- 818
            .:.....||                      .:||      .|.|       .|:.:|::...  
Mouse  1181 LRTCTPQPPTGPEASVLENGELAKLVLDPQAPQGLAPNAAQVQGWTLTCQQLRALLHKRFLLARR 1245

  Fly   819 SNEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLKLS--QMGSGVIYVHNPTGHHAHLEQ 881
            |...|:..::|...||    .:.:..::.:....:..||:||  ..|..|.:.........:..:
Mouse  1246 SRRGLFAQVVLPALFV----GLALFFSLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPGDPNRMK 1306

  Fly   882 QLRQQIELNGITAKTMH---LRGSN----------------DVKN---------ES--------- 909
            .|...:...|:...:|.   .|||.                ||.:         ||         
Mouse  1307 LLEALLGEAGLQEPSMQDKDARGSECTHSLACYFTVPEVPPDVASILASGNWTPESPSPACQCSQ 1371

  Fly   910 ------------------------------LDLQRDNLADFLEQVI------GI-----ID--MY 931
                                          .:|...|::|||.:..      |:     :|  .|
Mouse  1372 PGARRLLPDCPAGAGGPPPPQAVAGLGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVDEVRY 1436

  Fly   932 GG---GRGTSDTPT------------------------------------------IEIFYSGNR 951
            ||   |....|.||                                          ::|:::...
Mouse  1437 GGFSLGGRDPDLPTGHEVVRTLAEIRALLSPQPGNALDRILNNLTQWALGLDARNSLKIWFNNKG 1501

  Fly   952 YHSSVELINLVDSAMLKLGRPES------EIDTTYVPIRRFVSDISPSRL--EYYAVIVPIGMFF 1008
            :|:.|..:|..::.:|....|..      .|.|...|:......:|.:.|  ....|:|.|.:.|
Mouse  1502 WHAMVAFVNRANNGLLHALLPSGPVRHAHSITTLNHPLNLTKEQLSEATLIASSVDVLVSICVVF 1566

  Fly  1009 FMFY----FISLPFREYANGFKQLQTMS---RFTYWFAHFTFDML-ILIFVCVALFSLQSLMMPS 1065
            .|.:    |..:...|.....|.||.:|   :..||..:|.:||. .|:.||:.:|..  |....
Mouse  1567 AMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFLWDMCNYLVAVCIVVFIF--LAFQQ 1629

  Fly  1066 ELYTTAE-LKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLLLMLIVSAIAPLITSSNAAAM 1129
            ..|...| |..::|.:..||.|..|::|.....|...||  .|::|..|...|.  |.||.|..:
Mouse  1630 RAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPST--AYVVLTCINLFIG--INSSMATFV 1690

  Fly  1130 KLHETKIAFLCFLPDFNLNHQFRIINENFITRRHPALIKGLISQDTFFAYATA------------ 1182
                     |..|.|.||....||:.:.|:...|..|.:|||......|.|.|            
Mouse  1691 ---------LELLSDQNLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDKQFQSP 1746

  Fly  1183 -----VGVMVMA---------FFTIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPST------ 1227
                 :|..::|         ..|::|:|   |.|:                   ||.:      
Mouse  1747 LRWDIIGKNLLAMMAQGPLFLLITLLLQH---RNRL-------------------LPQSKPRLLP 1789

  Fly  1228 PISEID-DCAREEKRVTDLIKDPLNDHSLIVHNLRKRYGDKL--AVDGVSFAAAQGECFGLLGVN 1289
            |:.|.| |.|:|.:|||   |.......|::.:|.|.|..:.  |||.:......||||||||||
Mouse  1790 PLGEEDEDVAQERERVT---KGATQGDVLVLRDLTKVYRGQRNPAVDRLCLGIPPGECFGLLGVN 1851

  Fly  1290 GAGKTSTFQMIAAN-LPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMAL 1353
            ||||||||:|:..: ||..|..: :.|.::.:.........|||||.||:...:|..:.|...|.
Mouse  1852 GAGKTSTFRMVTGDTLPSSGEAV-LAGHNVAQERSAAHRSMGYCPQSDAIFDLLTGREHLELFAR 1915

  Fly  1354 LRGLSRRRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEP 1418
            |||:..      |...:.....|.::.|..|.......||||.||||..|:|::|.||:|.||||
Mouse  1916 LRGVPE------AQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEP 1974

  Fly  1419 TTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRL-- 1481
            |||:||.:|||||..:.....:.|:||||||||:|||.||.|||||.:|:|:||.:...||..  
Mouse  1975 TTGMDPSARRFLWNSLLSVVREGRSVVLTSHSMEECEALCTRLAIMVNGRFRCLGSSQHLKGRFG 2039

  Fly  1482 SGFTIKLKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEE 1546
            :|.|:.|::..| :.|..::.|..|    |||.||||.|...|.:.:.......| :.||:   |
Mouse  2040 AGHTLTLRVPPD-QPEPAIAFIRIT----FPGAELREVHGSRLRFQLPPGGRCTL-TRVFR---E 2095

  Fly  1547 YLGDRLSALVADYSVNECTLEDIFLKFER-EAKSQSTSRQ 1585
            ......:..|.|:||::.|||::||.|.: :.:.:.:|||
Mouse  2096 LAAQGRAHGVEDFSVSQTTLEEVFLYFSKDQGEEEESSRQ 2135

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EatoNP_001036360.1 ABC2_membrane_3 <209..347 CDD:289468 40/155 (26%)
CcmA 460..767 CDD:224054 108/361 (30%)
ABC_subfamily_A 461..679 CDD:213230 80/220 (36%)
ABC2_membrane_3 <937..1117 CDD:289468 50/238 (21%)
ABC_subfamily_A 1255..1479 CDD:213230 98/226 (43%)
drrA 1262..1573 CDD:130256 127/315 (40%)
Abca7NP_001334010.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1042..1088 1/45 (2%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1172..1192 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2126..2167 3/10 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838428
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
87.660

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