DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and Abca13

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_839990.2	Gene:	Abca13 / 268379	MGIID:	2388707	Length:	5034	Species:	Mus musculus

Alignment Length:	1863	Identity:	455/1863 - (24%)
Similarity:	755/1863 - (40%)	Gaps:	427/1863 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LHWS-VKPVLHQINQFEAKNEMVLRELYFPGNELDYIYYSPISPNVEDI----------MDLLRV 95
            |.|| :|||||                       ..|.|:|.||.:.::          :|.::|
Mouse  3273 LVWSFLKPVLH-----------------------GKILYTPNSPEINEVIQKANYTFYFVDKIKV 3314

  Fly    96 -------------------DLGIIPERLRPN--NNSFEMQLEMEQ-------QCRG--------- 123
                               ....:.:.||..  .|..|.||.::.       |..|
Mouse  3315 LSETFLKISKLFQGSGNGQMFNQLQDALRNKFIRNFVESQLHIDMDKLTEDLQTYGRMLDKMFNH 3379

  Fly   124 -----------------SCFAID--------------FHRVPNRGS---DRKFRYSLSSNQMRIS 154
                             ||..:|              .|.:..:.|   ...|..||....:|.:
Mouse  3380 VEAGHFRFLGGMLANLSSCVVLDRFQAVETVDTLETKAHELMQQNSFLASIIFNSSLRHRHIRSA 3444

  Fly   155 PRK-----RFVNDEEIYHQIDDD---------------------DYIRSGFLSLQHILDKQYMKY 193
            |.|     .:.....:.:.:..|                     :||   |:.||.::::..:..
Mouse  3445 PHKLPPHVTYTIRTNVLYSMRTDMIKNPSWKFHPQNLPAGGFKYNYI---FVPLQDMIERAIIVV 3506

  Fly   194 QELGKDFEVVVSSMP---NMEVISMDSHRLTYFGTLCSILFNVVLLSSFVVPFVEEKQNGLKEFL 255
            |...:..|....:..   ......:..:.:.:|..|..:|..:|.::|.|...|.|::..::|::
Mouse  3507 QTGQESLEPTTQAQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVAVASMVRKLVYEREIQIEEYM 3571

  Fly   256 NLVTPMSFLNGLTFFLIRFVCYTLLMIFVLVVAYLYKALGSICF--AYVAVLFLL-YILSTMSYA 317
            .::.....::.|::||...   ..|.:....:|.:.|..|....  |::..|:|| :.:|.:..:
Mouse  3572 RMMGLHPTIHFLSWFLENM---ATLALSSAALAVILKMSGIFMHSDAFIIFLYLLDFGVSAVMMS 3633

  Fly   318 YLISICFHSVFYAKIG---GLAMLIIPYAFSFV----RSWATSLAFVCFSTNTFLEGLDIFQTFS 375
            |.:|:.|:....|.:.   |..:..:||....|    .|:|........||..|.:|:.......
Mouse  3634 YFLSVFFNQANTAALCTSLGYMISFLPYVVLLVLHNQLSFAIQTLLCLLSTTAFGQGVFFITFLE 3698

  Fly   376 NKRKNREFGAVDVFRVIKSNSSTMFSVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDP 440
            .:.:..::|  :::|..:....|...|..:::|.:.||.:...|...:.||..||.:|.:|   |
Mouse  3699 GQEEGIQWG--NMYRAPEPGGMTFGWVCWMILFDAILYFLGGWYFSNLVPGTFGLGKPWYF---P 3758

  Fly   441 KT--YMK-----------------------------RQRNEYTTTPRGTHAIIITELCKKFQTSK 474
            .|  |.|                             .|:|.......|...:.:..:.|:::..|
Mouse  3759 FTASYWKSICGLMERRRCSLSSGLFFFNEDFGNKGLSQQNGPGEMEGGNPGVALISVTKEYEDHK 3823

  Fly   475 RDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIVCS---ERDVASYRHLI 536
               :....|.:|.:..:||.|||.|||||||:::|:|||.|..||.|.:..   :.|::..|..:
Mouse  3824 ---VAVQELTLTFHRDQITALLGTNGAGKTTIISMLMGLFPPTSGTITINGKNLQTDLSKVREEL 3885

  Fly   537 GFCPQHSVFMSYMTCHQHLEFFAQLRGA--CRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKR 599
            |.|||..|.:..:|..:||..||.::..  ...:.:...::.|.::.|:..:::....|||||||
Mouse  3886 GVCPQQDVLLDNLTVREHLMLFASIKAPWWTTKELQQQVNKTLDEVELTQHQHKPAGVLSGGMKR 3950

  Fly   600 RLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICIL 664
            :||:|||..|.:|.|:|||||||:|..|||.||||||..|:.:.::.|||:::|||:|.|.:.:|
Mouse  3951 KLSIGIAFMGMSKTVVLDEPSSGVDPCSRRSLWDILLKYREGRTIIFTTHHLDEAEMLSDHVAVL 4015

  Fly   665 ANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEIME------------IIHHFVPTARVLN 717
            ..|:|:....|.:||...|.|..|.|      |::..|:|            :|..::|.|.:.:
Mouse  4016 QQGRLRCYAPPADLKETYGQGLTLTL------SKQPSILETQEPKDVARVTSLIQIYIPQAFLKD 4074

  Fly   718 VVNPTVYICLPY-AYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQVD--TPD 779
            .....:...:|. |.:.||..:...|:...:.|.:....::||:||:|||....:.::..  |||
Mouse  4075 SCGGELTYTIPKDADRTCFKGLCQALDQNLQHLHLTGYGISDTTLEEVFLMLLQDTNKKSYITPD 4139

  Fly   780 ------GSRNDAPLLAHYKRLQDHPPHRGL------FQLWM----AVFYKKWTFISNEWLYTLIM 828
                  ..|...||..|.......||...|      .||.:    |:..|:.......|..|...
Mouse  4140 NKVEPQNERPVGPLSPHNVSPLSTPPEGALPEPIGGCQLLLGQAVALLRKRLLHTLRAWKSTTSD 4204

  Fly   829 LCIP--FVCVFGAILVMHAMSLVENEEALPLKLSQ----------MGSGVIYVHNPTGHHAHLEQ 881
            |.:|  ||.:...:.::..:::...    ||||:.          ..||   .|.|...|. |.:
Mouse  4205 LLLPVLFVALAMGLFMVQPLAITYP----PLKLTPGHYETAETYFFSSG---NHGPDLTHV-LLR 4261

  Fly   882 QLRQQIELNGITAKTMHLRGSNDVKN-----ESLD----LQRDNL---ADFLEQVIG--IIDMYG 932
            :.|.|   :.:.|....:..|:..::     ||.|    |:..|.   |..|...:|  ::::.|
Mouse  4262 KFRDQ---DPVCADAFRMNSSSWHRDPYSGPESQDSCGCLKCPNKSAGAPSLTNCLGHTLLNLSG 4323

  Fly   933 ---------------------GGRGTSDTPTI-----------EIFYSGNRYHSSVELINLVDSA 965
                                 ||:..:|...:           :::|:...:||....:|.:::.
Mouse  4324 YDVEEYLLVPSAKPRLGGWSFGGQIPNDAEDVKTNTSKPRTLAKVWYNQKGFHSLPSYLNHLNNL 4388

  Fly   966 MLKLGRPESEIDTTYVPIRRFVSDISPSRLEY-----------YAVIVPIGMFFFMFYFISLPFR 1019
            :|....|.:.:|.....|..:......:.|..           .|:.:.:|.........|...|
Mouse  4389 ILWHHLPANAVDWRQYGITLYSHPYGGALLNEDRILESIRQCGVALCIVLGFSILSASIGSSVVR 4453

  Fly  1020 EYANGFKQLQTMSRF---TYWFAHFTFDM---LILIFVCVAL---FSLQSLMMPSELYTTAELKV 1075
            :...|.|:||.:|..   |||..:|.:||   |:.:.:|||:   |.|.:......|..||
Mouse  4454 DRVTGAKRLQHISGLGHRTYWLINFLYDMLFYLVSVCLCVAVIGAFQLTAFTFRENLAATA---- 4514

  Fly  1076 IVLSIFFYGCSYLPILYALGNNFKS-----ISTISTYL------LLMLIVSAIAPLITSSNAAAM 1129
            ::|::|  |.:.:|.:|.:...|.|     ||.||...      :||..:..:..:|:.:.....
Mouse  4515 LLLALF--GYAMIPWMYLMSRIFSSSDVAFISYISLNFIFGLCTMLMTTMPRLLAIISKAQNLQK 4577

  Fly  1130 KLHETKIAFLCFLPDF----------------NLNHQFRI------INENFITRRHPALIKGLIS 1172
            ..:..|.||..| |.|                :|.|.|.|      ...||:         |.|
Mouse  4578 IYNVLKWAFTIF-PQFCLGQGLIELCYNQIKYDLTHNFGIDSYVSPFEMNFL---------GWI- 4631

  Fly  1173 QDTFFAYATAVGVMVMAFFTIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDDCAR 1237
                |...|..|..::          .||..:|..:..|..........    ..|..:| |...
Mouse  4632 ----FVELTLQGTFLL----------LLRLMLHGDLLRWPRDHSVLQDI----VKPAKDI-DVET 4677

  Fly  1238 EEKRVTDLIKDPLNDHSLIVHNLRKRY-----GDKLAVDGVSFAAAQGECFGLLGVNGAGKTSTF 1297
            |:.||   ::.......:::.||.|.|     |...||.|:|....:||||||||||||||::||
Mouse  4678 EQMRV---LEGRTGGDMMVLCNLSKSYRSVFGGKTTAVHGISLGIPRGECFGLLGVNGAGKSTTF 4739

  Fly  1298 QMIAANLPLDGG--TIRIKGADIRE--HELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLS 1358
            :::....|...|  .||....|:.:  ...|.....|||||.|||::.:|..:.|.|...|||:.
Mouse  4740 KILNGETPPSSGYTVIRTPQGDMVDLASAGKAGILIGYCPQQDALDELLTGWEHLQYYCRLRGIP 4804

  Fly  1359 RRRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVD 1423
            ::..  |....:.|:    ::||..:....|..|||||:|||..|:|::|.|.::|||||::|:|
Mouse  4805 KQYI--PEVAADLVR----RLHLESHVDKPVATYSGGTRRKLSTALALVGKPDILLLDEPSSGMD 4863

  Fly  1424 PISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTI 1486
            |.|:|:|||.|..........|||||||:|||.||.|||||..|.|:||.....:|..  .|:|:
Mouse  4864 PCSKRYLWQTITQEVRDGCAAVLTSHSMEECEALCTRLAIMVDGSFRCLGPPQHIKNRFGDGYTV 4928

  Fly  1487 KLKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDR 1551
            |:.:..:..   ..|.::..||..|||::.:......|.|.|  |:|....:.:||:.|    :.
Mouse  4929 KVWLHKEGS---QPSAVSDCLKLHFPGIQFKGQRLNLLEYHV--QKSWECLADLFKVLE----NN 4984

  Fly  1552 LSAL-VADYSVNECTLEDIFLKFERE--------AKSQSTSRQ 1585
            .|.| :..||:::.|||.:|:.|..|        ..|.||..|
Mouse  4985 KSLLNIEHYSISQTTLEQVFVNFATEQLQTPCFPVDSPSTDAQ 5027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	28/143 (20%)
		CcmA	460..767	CDD:224054	107/324 (33%)
		ABC_subfamily_A	461..679	CDD:213230	83/222 (37%)
		ABC2_membrane_3	<937..1117	CDD:289468	47/221 (21%)
		ABC_subfamily_A	1255..1479	CDD:213230	97/232 (42%)
		drrA	1262..1573	CDD:130256	121/322 (38%)
Abca13	NP_839990.2	rim_protein	3036..5019	CDD:130324	451/1853 (24%)
		ABC_subfamily_A	3815..4030	CDD:213230	83/217 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4135..4165		7/29 (24%)
		ABC_subfamily_A	4692..4919	CDD:213230	97/232 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838492
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750