DRSC/TRiP Functional Genomics Resources

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Protein Alignment Eato and ABCA12

DIOPT Version :10

Sequence 1:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster
Sequence 2:XP_011509253.1 Gene:ABCA12 / 26154 HGNCID:14637 Length:2598 Species:Homo sapiens


Alignment Length:1855 Identity:462/1855 - (24%)
Similarity:786/1855 - (42%) Gaps:391/1855 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 TPLFFVFLRKNLLYLQRNLLPLL--LICSGFAGVLTAYLHWSV----KPVLHQINQFEAKNEMVL 64
            :|||.     |..:|....:|:|  .:.:.|..|   ::.:||    ..:|.||           
Human   846 SPLFM-----NSFHLLNQAIPMLQNTLRNPFVQV---FVKFSVGLDAVELLKQI----------- 891

  Fly    65 RELYFPGNELDYIYYSPISPNVEDIMDLL--------RVDLGIIPERLRPNNNSFEMQLEMEQQC 121
                   :||| |....:..|: ||:|.|        .:...::.:|::......||:.|.::..
Human   892 -------DELD-ILRLKLENNI-DIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLY 947

  Fly   122 RGS------CFAIDFHRVPNRGSDR-----------KFRYSLSSNQMRISPRKRF----VNDEEI 165
            :.:      .|.:..:|..:||.|.           ..|.||.:.|...|.|.:.    .::...
Human   948 KSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPS 1012

  Fly   166 YHQIDDDDYIRSGFLSLQHILDKQYMKYQELGKDFEVVVSSMPNMEVISMDSHRLT---YFGTLC 227
            ::||    |.|: |:.||..:::..::.|......|:.|..........|..:.||   |...:.
Human  1013 HNQI----YGRA-FIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIV 1072

  Fly   228 SILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFF---LIRFVCYTLLMIFVLVVA- 288
            .::..||.:::||...|.||...|.|::.    |..:|..:.|   ||..|.:.|:.|.:|::. 
Human  1073 LMVAWVVFIAAFVKKLVYEKDLRLHEYMK----MMGVNSCSHFFAWLIESVGFLLVTIVILIIIL 1133

  Fly   289 ----YLYKALGSICFAYVAVLFLLYILSTMSYAYLISICFHSV-FYAKIGGLAMLIIPYAFSFVR 348
                .|.|..|.|.|.|    |..|..|.::.:||||:.|::. ..|.||.|..:|..:.|..:.
Human  1134 KFGNILPKTNGFILFLY----FSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLV 1194

  Fly   349 SWATSLAFVCFSTNTFLEGLDIFQT------------FSNKRKNREFGA--VDVFRVIKSNSSTM 399
            :....|::|          |.:|.:            :..:.:.:..|.  .:::.....:.:|.
Human  1195 TVENELSYV----------LKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTS 1249

  Fly   400 FSVYVVLVF-QSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRNEYTTTPRGTHAIII 463
            |.....|:. .||:|.::..|:..||||..|:..|.:|.:.| :|.|.:.......|..::.::.
Human  1250 FGWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILP-SYWKERFGCAEVKPEKSNGLMF 1313

  Fly   464 TEL------------------CKKFQTSKRDTLIS----------------DNLNMTINNKEITV 494
            |.:                  ....:...:|..:.                ||||:......||.
Human  1314 TNIMMQNTNPSASKTSPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITS 1378

  Fly   495 LLGHNGAGKTTMMNMIMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLE 556
            |||.|||||||.::|:.||....:|.|.|..   :.|:.:.|..:|.|.||.|..||:|..:||.
Human  1379 LLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLL 1443

  Fly   557 FFAQLRGACRSDARDWADEK--------LKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKI 613
            .:..::      ...|..::        ||..||...|::....|||||||:||:.||:.|.:::
Human  1444 LYGSIK------VPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRV 1502

  Fly   614 VILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLEL 678
            |||||||:|:|..|||.:||::...:..:.::::||:::|||||.|.|..|..|.|:..|||..|
Human  1503 VILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYL 1567

  Fly   679 KRKSGIGYRLKL------EIN-DFTSREVEIMEIIHHFVPTARVL-NVVNPTVYICLPYAYK--N 733
            |...|.||.|.|      .:| :.....:.:..:|...:|.|.:. ::....||:..|::.|  .
Human  1568 KEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSG 1632

  Fly   734 CFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQ---------------------VDT 777
            .:..:|..|:....:|.|....::||::|:|||....|..:                     :.|
Human  1633 AYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSNANGIST 1697

  Fly   778 PD----GSRN----DAPLLAHYKRLQDHPPHRG-LFQLWMAVFYKKWTFISNEWLYTLIMLCIPF 833
            ||    .|.|    |..:|...:||...    | |.:..||:..|::......|...:..:.:|.
Human  1698 PDDLSVSSSNFTDRDDKILTRGERLDGF----GLLLKKIMAILIKRFHHTRRNWKGLIAQVILPI 1758

  Fly   834 VCVFGAILVMHAMSLVENEEALP---LKLSQMGSG---VIYVHNPTGHHAHLEQQLRQQIELNGI 892
            |.|..|   |...:|..:..:.|   :..|..|:.   ..|.:    :|...|..:....:..||
Human  1759 VFVTTA---MGLGTLRNSSNSYPEIQISPSLYGTSEQTAFYAN----YHPSTEALVSAMWDFPGI 1816

  Fly   893 TAKTMHLRGSNDVKNESLDLQR---------------DNLAD-------------FLEQVI---- 925
            ....::......:..:||:...               :|:.:             :..|||    
Human  1817 DNMCLNTSDLQCLNKDSLEKWNTSGEPITNFGVCSCSENVQECPKFNYSPPHRRTYSSQVIYNLT 1881

  Fly   926 --------------GIIDMYGGG--------------RGTSDTPTI-EIFYSGNRYHSSVELINL 961
                          .:...|||.              .|.....|: :::|....|||....:|.
Human  1882 GQRVENYLISTANEFVQKRYGGWSFGLPLTKDLRFDITGVPANRTLAKVWYDPEGYHSLPAYLNS 1946

  Fly   962 VDSAMLKLGRPESEIDTTYVPIRRF------VSDISPSRLEYYAVIVPIGMFFFMFY------FI 1014
            :::.:|::..  |:.|.....|..:      |.|...:.:.....|: :.:...|.|      |:
Human  1947 LNNFLLRVNM--SKYDAARHGIIMYSHPYPGVQDQEQATISSLIDIL-VALSILMGYSVTTASFV 2008

  Fly  1015 SLPFREYANGFKQLQTMSRF---TYWFAHFTFDMLI-LIFVCVALFSLQSLMMPSELYTTAELKV 1075
            :...||:....||||.:|..   .||..:|.:||:. |:.|..::..:....:|: .|:...|..
Human  2009 TYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPA-FYSENNLGA 2072

  Fly  1076 IVLSIFFYGCSYLPILYALGNNFKSIS-TISTYLLLMLI--VSAIAPLIT-------SSNAAAMK 1130
            :.|.:..:|.:....:|.|...|.... ...||:.:.|.  :::|..|..       ..|...::
Human  2073 VSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLE 2137

  Fly  1131 L-HET-KIAFLCFLPDF-------NLNHQFRII-----------NENFITRRHPALIKGLISQDT 1175
            | .|| |..||.| |.|       .|:.|..::           ||.|...:..|:...|:||.|
Human  2138 LISETLKRIFLIF-PQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGT 2201

  Fly  1176 FFAYATAVGVMVMAFFTIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDDCAREEK 1240
            .|            |...:|.::.|.:::.      .|.| |:||:....:  |.|.:|...|..
Human  2202 MF------------FSLRLLINESLIKKLR------LFFR-KFNSSHVRET--IDEDEDVRAERL 2245

  Fly  1241 RVT------DLIKDPLNDHSLIVHNLRKRY----GDKLAVDGVSFAAAQGECFGLLGVNGAGKTS 1295
            ||.      ||::         ::.|.|.|    ...:||:.:|.....|||||||||||||||:
Human  2246 RVESGAAEFDLVQ---------LYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTT 2301

  Fly  1296 TFQMIAANLPLDGGTIRIKG-ADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSR 1359
            .|:|:..::....|.|.|:. .....|...:....|||||.|||:..:|.|:.||:.|.:.|:..
Human  2302 IFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPE 2366

  Fly  1360 RRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDP 1424
            :      ..||.|...|.::||..::.......|.||||||..|:|:||.|:::|||||::|:||
Human  2367 K------DIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDP 2425

  Fly  1425 ISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIK 1487
            .|:|.||:.|.:......:|:||||||:|||.||.|||||.:|||:|:.::..:|..  .|||:|
Human  2426 KSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVK 2490

  Fly  1488 LKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRL 1552
            :.:|   ..::.:.|:|..::..||...|::.|...|.|.|......|  :::|.:.|.   ::.
Human  2491 VHLK---NNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGV--ANIFDLLET---NKT 2547

  Fly  1553 SALVADYSVNECTLEDIFLKFEREAKSQSTSRQTS 1587
            :..:.::.|::.|||::|:.|.::.||..|:..:|
Human  2548 ALNITNFLVSQTTLEEVFINFAKDQKSYETADTSS 2582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EatoNP_001036360.1 rim_protein <169..1591 CDD:130324 423/1657 (26%)
ABCA12XP_011509253.1 rim_protein 7..>86 CDD:130324
rim_protein 752..2579 CDD:130324 461/1850 (25%)
Blue background indicates that the domain is not in the aligned region.

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