DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and ABCA12

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	XP_011509253.1	Gene:	ABCA12 / 26154	HGNCID:	14637	Length:	2598	Species:	Homo sapiens

Alignment Length:	1855	Identity:	462/1855 - (24%)
Similarity:	786/1855 - (42%)	Gaps:	391/1855 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TPLFFVFLRKNLLYLQRNLLPLL--LICSGFAGVLTAYLHWSV----KPVLHQINQFEAKNEMVL 64
            :|||.     |..:|....:|:|  .:.:.|..|   ::.:||    ..:|.||
Human   846 SPLFM-----NSFHLLNQAIPMLQNTLRNPFVQV---FVKFSVGLDAVELLKQI----------- 891

  Fly    65 RELYFPGNELDYIYYSPISPNVEDIMDLL--------RVDLGIIPERLRPNNNSFEMQLEMEQQC 121
                   :||| |....:..|: ||:|.|        .:...::.:|::......||:.|.::..
Human   892 -------DELD-ILRLKLENNI-DIIDQLNTLSSLTVNISSCVLYDRIQAAKTIDEMEREAKRLY 947

  Fly   122 RGS------CFAIDFHRVPNRGSDR-----------KFRYSLSSNQMRISPRKRF----VNDEEI 165
            :.:      .|.:..:|..:||.|.           ..|.||.:.|...|.|.:.    .::...
Human   948 KSNELFGSVIFKLPSNRSWHRGYDSGNVFLPPVIKYTIRMSLKTAQTTRSLRTKIWAPGPHNSPS 1012

  Fly   166 YHQIDDDDYIRSGFLSLQHILDKQYMKYQELGKDFEVVVSSMPNMEVISMDSHRLT---YFGTLC 227
            ::||    |.|: |:.||..:::..::.|......|:.|..........|..:.||   |...:.
Human  1013 HNQI----YGRA-FIYLQDSIERAIIELQTGRNSQEIAVQVQAIPYPCFMKDNFLTSVSYSLPIV 1072

  Fly   228 SILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFF---LIRFVCYTLLMIFVLVVA- 288
            .::..||.:::||...|.||...|.|::.    |..:|..:.|   ||..|.:.|:.|.:|::.
Human  1073 LMVAWVVFIAAFVKKLVYEKDLRLHEYMK----MMGVNSCSHFFAWLIESVGFLLVTIVILIIIL 1133

  Fly   289 ----YLYKALGSICFAYVAVLFLLYILSTMSYAYLISICFHSV-FYAKIGGLAMLIIPYAFSFVR 348
                .|.|..|.|.|.|    |..|..|.::.:||||:.|::. ..|.||.|..:|..:.|..:.
Human  1134 KFGNILPKTNGFILFLY----FSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYIIAFFPFIVLV 1194

  Fly   349 SWATSLAFVCFSTNTFLEGLDIFQT------------FSNKRKNREFGA--VDVFRVIKSNSSTM 399
            :....|::|          |.:|.:            :..:.:.:..|.  .:::.....:.:|.
Human  1195 TVENELSYV----------LKVFMSLLSPTAFSYASQYIARYEEQGIGLQWENMYTSPVQDDTTS 1249

  Fly   400 FSVYVVLVF-QSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRNEYTTTPRGTHAIII 463
            |.....|:. .||:|.::..|:..||||..|:..|.:|.:.| :|.|.:.......|..::.::.
Human  1250 FGWLCCLILADSFIYFLIAWYVRNVFPGTYGMAAPWYFPILP-SYWKERFGCAEVKPEKSNGLMF 1313

  Fly   464 TEL------------------CKKFQTSKRDTLIS----------------DNLNMTINNKEITV 494
            |.:                  ....:...:|..:.                ||||:......||.
Human  1314 TNIMMQNTNPSASKTSPEYMFSSNIEPEPKDLTVGVALHGVTKIYGSKVAVDNLNLNFYEGHITS 1378

  Fly   495 LLGHNGAGKTTMMNMIMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLE 556
            |||.|||||||.::|:.||....:|.|.|..   :.|:.:.|..:|.|.||.|..||:|..:||.
Human  1379 LLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTVRKNMGVCMQHDVLFSYLTTKEHLL 1443

  Fly   557 FFAQLRGACRSDARDWADEK--------LKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKI 613
            .:..::      ...|..::        ||..||...|::....|||||||:||:.||:.|.:::
Human  1444 LYGSIK------VPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRV 1502

  Fly   614 VILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLEL 678
            |||||||:|:|..|||.:||::...:..:.::::||:::|||||.|.|..|..|.|:..|||..|
Human  1503 VILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYL 1567

  Fly   679 KRKSGIGYRLKL------EIN-DFTSREVEIMEIIHHFVPTARVL-NVVNPTVYICLPYAYK--N 733
            |...|.||.|.|      .:| :.....:.:..:|...:|.|.:. ::....||:..|::.|  .
Human  1568 KEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSG 1632

  Fly   734 CFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQ---------------------VDT 777
            .:..:|..|:....:|.|....::||::|:|||....|..:                     :.|
Human  1633 AYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLEHLTQKKIGNSNANGIST 1697

  Fly   778 PD----GSRN----DAPLLAHYKRLQDHPPHRG-LFQLWMAVFYKKWTFISNEWLYTLIMLCIPF 833
            ||    .|.|    |..:|...:||...    | |.:..||:..|::......|...:..:.:|.
Human  1698 PDDLSVSSSNFTDRDDKILTRGERLDGF----GLLLKKIMAILIKRFHHTRRNWKGLIAQVILPI 1758

  Fly   834 VCVFGAILVMHAMSLVENEEALP---LKLSQMGSG---VIYVHNPTGHHAHLEQQLRQQIELNGI 892
            |.|..|   |...:|..:..:.|   :..|..|:.   ..|.:    :|...|..:....:..||
Human  1759 VFVTTA---MGLGTLRNSSNSYPEIQISPSLYGTSEQTAFYAN----YHPSTEALVSAMWDFPGI 1816

  Fly   893 TAKTMHLRGSNDVKNESLDLQR---------------DNLAD-------------FLEQVI---- 925
            ....::......:..:||:...               :|:.:             :..|||
Human  1817 DNMCLNTSDLQCLNKDSLEKWNTSGEPITNFGVCSCSENVQECPKFNYSPPHRRTYSSQVIYNLT 1881

  Fly   926 --------------GIIDMYGGG--------------RGTSDTPTI-EIFYSGNRYHSSVELINL 961
                          .:...|||.              .|.....|: :::|....|||....:|.
Human  1882 GQRVENYLISTANEFVQKRYGGWSFGLPLTKDLRFDITGVPANRTLAKVWYDPEGYHSLPAYLNS 1946

  Fly   962 VDSAMLKLGRPESEIDTTYVPIRRF------VSDISPSRLEYYAVIVPIGMFFFMFY------FI 1014
            :::.:|::..  |:.|.....|..:      |.|...:.:.....|: :.:...|.|      |:
Human  1947 LNNFLLRVNM--SKYDAARHGIIMYSHPYPGVQDQEQATISSLIDIL-VALSILMGYSVTTASFV 2008

  Fly  1015 SLPFREYANGFKQLQTMSRF---TYWFAHFTFDMLI-LIFVCVALFSLQSLMMPSELYTTAELKV 1075
            :...||:....||||.:|..   .||..:|.:||:. |:.|..::..:....:|: .|:...|..
Human  2009 TYVVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVAFSIGIIAIFKLPA-FYSENNLGA 2072

  Fly  1076 IVLSIFFYGCSYLPILYALGNNFKSIS-TISTYLLLMLI--VSAIAPLIT-------SSNAAAMK 1130
            :.|.:..:|.:....:|.|...|.... ...||:.:.|.  :::|..|..       ..|...::
Human  2073 VSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLE 2137

  Fly  1131 L-HET-KIAFLCFLPDF-------NLNHQFRII-----------NENFITRRHPALIKGLISQDT 1175
            | .|| |..||.| |.|       .|:.|..::           ||.|...:..|:...|:||.|
Human  2138 LISETLKRIFLIF-PQFCFGYGLIELSQQQSVLDFLKAYGVEYPNETFEMNKLGAMFVALVSQGT 2201

  Fly  1176 FFAYATAVGVMVMAFFTIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDDCAREEK 1240
            .|            |...:|.::.|.:::.      .|.| |:||:....:  |.|.:|...|..
Human  2202 MF------------FSLRLLINESLIKKLR------LFFR-KFNSSHVRET--IDEDEDVRAERL 2245

  Fly  1241 RVT------DLIKDPLNDHSLIVHNLRKRY----GDKLAVDGVSFAAAQGECFGLLGVNGAGKTS 1295
            ||.      ||::         ::.|.|.|    ...:||:.:|.....|||||||||||||||:
Human  2246 RVESGAAEFDLVQ---------LYCLTKTYQLIHKKIIAVNNISIGIPAGECFGLLGVNGAGKTT 2301

  Fly  1296 TFQMIAANLPLDGGTIRIKG-ADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSR 1359
            .|:|:..::....|.|.|:. .....|...:....|||||.|||:..:|.|:.||:.|.:.|:..
Human  2302 IFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSLVGYCPQEDALDDLVTVEEHLYFYARVHGIPE 2366

  Fly  1360 RRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDP 1424
            :      ..||.|...|.::||..::.......|.||||||..|:|:||.|:::|||||::|:||
Human  2367 K------DIKETVHKLLRRLHLMPFKDRATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDP 2425

  Fly  1425 ISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIK 1487
            .|:|.||:.|.:......:|:||||||:|||.||.|||||.:|||:|:.::..:|..  .|||:|
Human  2426 KSKRHLWKIISEEVQNKCSVILTSHSMEECEALCTRLAIMVNGKFQCIGSLQHIKSRFGRGFTVK 2490

  Fly  1488 LKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRL 1552
            :.:|   ..::.:.|:|..::..||...|::.|...|.|.|......|  :::|.:.|.   ::.
Human  2491 VHLK---NNKVTMETLTKFMQLHFPKTYLKDQHLSMLEYHVPVTAGGV--ANIFDLLET---NKT 2547

  Fly  1553 SALVADYSVNECTLEDIFLKFEREAKSQSTSRQTS 1587
            :..:.::.|::.|||::|:.|.::.||..|:..:|
Human  2548 ALNITNFLVSQTTLEEVFINFAKDQKSYETADTSS 2582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	42/149 (28%)
		CcmA	460..767	CDD:224054	107/361 (30%)
		ABC_subfamily_A	461..679	CDD:213230	83/262 (32%)
		ABC2_membrane_3	<937..1117	CDD:289468	41/199 (21%)
		ABC_subfamily_A	1255..1479	CDD:213230	93/228 (41%)
		drrA	1262..1573	CDD:130256	115/317 (36%)
ABCA12	XP_011509253.1	ABC2_membrane_3	<1026..1270	CDD:289468	56/261 (21%)
		ZnuC	1349..1573	CDD:224046	83/229 (36%)
		ABC_subfamily_A	1353..1568	CDD:213230	81/220 (37%)
		ABC2_membrane_3	<1916..2177	CDD:289468	56/265 (21%)
		ABC_subfamily_A	2257..2480	CDD:213230	93/237 (39%)
		CcmA	2262..2570	CDD:224054	117/321 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750