DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and ABCA4

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_000341.2	Gene:	ABCA4 / 24	HGNCID:	34	Length:	2273	Species:	Homo sapiens

Alignment Length:	1760	Identity:	459/1760 - (26%)
Similarity:	733/1760 - (41%)	Gaps:	431/1760 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 IDDDDYIRSGFLSLQHILDKQYMKYQ-ELGKDFEVVVSSMPNMEVISMDSHRLTYFGTLCSILFN 232
            ::|..||..||..||.::::...:.| :......:.:..||....:. ||..:..  ..|..:|.
Human   598 VEDFRYIWGGFAYLQDMVEQGITRSQVQAEAPVGIYLQQMPYPCFVD-DSFMIIL--NRCFPIFM 659

  Fly   233 VVL----LSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRF----VCYTLLMIFVLVVAY 289
            |:.    :|..|...|.||:..|||.|......:.:...|:||..|    :...||.||::....
Human   660 VLAWIYSVSMTVKSIVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTIFIMHGRI 724

  Fly   290 LYKALGSICFAYV-----AVLFLLYILST-MSYAYLISICFHSVFYAKIGGLAMLIIPYAFSFVR 348
            |:.:...|.|.::     |.:.|.::||| .|.|.|.:.|...:::.       |.:|:...|
Human   725 LHYSDPFILFLFLLAFSTATIMLCFLLSTFFSKASLAAACSGVIYFT-------LYLPHILCF-- 780

  Fly   349 SWATSL------AFVCFSTNTFLEGLDIFQTFSNKRKNREFGAVDVFRVIKSNSST-------MF 400
            :|...:      |....|...|..|.:....|..:....::..:       .||.|       :.
Human   781 AWQDRMTAELKKAVSLLSPVAFGFGTEYLVRFEEQGLGLQWSNI-------GNSPTEGDEFSFLL 838

  Fly   401 SVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLD------------------PKTYMKRQ 447
            |:.::|: .:.:|.:|..||..||||..|...|.:|.|.                  .||....:
Human   839 SMQMMLL-DAAVYGLLAWYLDQVFPGDYGTPLPWYFLLQESYWLGGEGCSTREERALEKTEPLTE 902

  Fly   448 RNEYTTTPRGTH-------------AIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHN 499
            ..|....|.|.|             .:.:..|.|.|:...|..:  |.||:|....:||..||||
Human   903 ETEDPEHPEGIHDSFFEREHPGWVPGVCVKNLVKIFEPCGRPAV--DRLNITFYENQITAFLGHN 965

  Fly   500 GAGKTTMMNMIMGLVPKDSGKIIVCSERDVA----SYRHLIGFCPQHSVFMSYMTCHQHLEFFAQ 560
            ||||||.::::.||:|..||.::| ..||:.    :.|..:|.||||::...::|..:|:.|:||
Human   966 GAGKTTTLSILTGLLPPTSGTVLV-GGRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQ 1029

  Fly   561 LRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDI 625
            |:|..:.:|:...:..|:..||..||||..::|||||:|:||:.||..|:.|:||||||:||:|.
Human  1030 LKGKSQEEAQLEMEAMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDP 1094

  Fly   626 NSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKL 690
            .|||.:||:||..|..:.::::||:|:||::|||.|.|:|.|:|...|:||.||...|.|..|.|
Human  1095 YSRRSIWDLLLKYRSGRTIIMSTHHMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTL 1159

  Fly   691 -------------------------------EINDFTSREV------EIMEIIHHFVPTARVLNV 718
                                           .::|.|..:|      |:|:::.|.||.|:::..
Human  1160 VRKMKNIQSQRKGSEGTCSCSSKGFSTTCPAHVDDLTPEQVLDGDVNELMDVVLHHVPEAKLVEC 1224

  Fly   719 VNPTVYICLPYAYKN----CFAQMLYRLETESKELGIHTISMTDTSLEDVFLR------------ 767
            :...:...||  .||    .:|.:...||....:||:.:..::||.||::||:
Human  1225 IGQELIFLLP--NKNFKHRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSDSGPLFA 1287

  Fly   768 ---------------CAGEQDQV-DTPDGSRNDAP--LLAHYKRLQDHPP----------HRG-- 802
                           |.|.:::. .||..|...:|  ..||   .:..||          :.|
Human  1288 GGAQQKRENVNPRHPCLGPREKAGQTPQDSNVCSPGAPAAH---PEGQPPPEPECPGPQLNTGTQ 1349

  Fly   803 -LFQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPL--------- 857
             :.|...|:..|::..........|..:.:|...||.|:::...:.......||.|
Human  1350 LVLQHVQALLVKRFQHTIRSHKDFLAQIVLPATFVFLALMLSIVIPPFGEYPALTLHPWIYGQQY 1414

  Fly   858 ---KLSQMGSGVIYV----------------------HNPTGHHA---------HLEQQLRQQ-- 886
               .:.:.||....|                      ..|.|:..         ::.|..::|
Human  1415 TFFSMDEPGSEQFTVLADVLLNKPGFGNRCLKEGWLPEYPCGNSTPWKTPSVSPNITQLFQKQKW 1479

  Fly   887 IELN-----------------------GITAKTMHLRGSNDVKNESLDLQRDNLADFL------- 921
            .::|                       |........:.|.::..   ||...|::|||
Human  1480 TQVNPSPSCRCSTREKLTMLPECPEGAGGLPPPQRTQRSTEILQ---DLTDRNISDFLVKTYPAL 1541

  Fly   922 --------------------------------EQVIGIIDMYG------GG----RGTSDTP--- 941
                                            |.::|.:...|      ||    ..:.:.|
Human  1542 IRSSLKSKFWVNEQRYGGISIGGKLPVVPITGEALVGFLSDLGRIMNVSGGPITREASKEIPDFL 1606

  Fly   942 -------TIEIFYSGNRYHSSVELINLVDSAMLKLGRPESEIDTTY------VPI---RRFVSDI 990
                   .|:::::...:|:.|..:|:..:|:|:...|:......|      .|:   :..:|:|
Human  1607 KHLETEDNIKVWFNNKGWHALVSFLNVAHNAILRASLPKDRSPEEYGITVISQPLNLTKEQLSEI 1671

  Fly   991 SPSRLEYYAVI---VPIGMFFFMFYFISLPFREYANGFKQLQTMSRF---TYWFAHFTFDML--- 1046
            :.......||:   |...|.|....|:....:|..|..|.||.:|..   |||..:|.:|::
Human  1672 TVLTTSVDAVVAICVIFSMSFVPASFVLYLIQERVNKSKHLQFISGVSPTTYWVTNFLWDIMNYS 1736

  Fly  1047 ILIFVCVALFSLQSLMMPSELYTTAE-LKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLLL 1110
            :...:.|.:|    :....:.||:.| |..:|..:..||.:.:|::|.....|...||  .|:.|
Human  1737 VSAGLVVGIF----IGFQKKAYTSPENLPALVALLLLYGWAVIPMMYPASFLFDVPST--AYVAL 1795

  Fly  1111 MLIVSAIAPLITSSNAAA----MKLHETKIAFLCFLPDFNLNHQFRIINENFITRRHPALIKGLI 1171
                 :.|.|....|::|    ::|.|.....|    .||     .::.:..|...|..|.:|||
Human  1796 -----SCANLFIGINSSAITFILELFENNRTLL----RFN-----AVLRKLLIVFPHFCLGRGLI 1846

  Fly  1172 ----SQDTFFAYA-----------------------TAVGVMVMAFFTIVLEHKYLRRRIHDGIW 1209
                ||.....||                       ...||:......:|..|.:|.
Human  1847 DLALSQAVTDVYARFGEEHSANPFHWDLIGKNLFAMVVEGVVYFLLTLLVQRHFFLS-------- 1903

  Fly  1210 EWAFQRKKYNSTGTLPSTPI-SEIDDCAREEKRV------TDLIKDPLNDHSLIVHNLRKRY--G 1265
            :|..:..|         .|| .|.||.|.|.:|:      ||:::         :|.|.|.|  .
Human  1904 QWIAEPTK---------EPIVDEDDDVAEERQRIITGGNKTDILR---------LHELTKIYPGT 1950

  Fly  1266 DKLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFG 1330
            ...|||.:......|||||||||||||||:||:|:..:..:..|...:.|..|..:..:..:..|
Human  1951 SSPAVDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATVAGKSILTNISEVHQNMG 2015

  Fly  1331 YCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYW-LEKMHLTKYQKVQVRHYSG 1394
            ||||:||:::.:|..:.||..|.|||:       ||...|.|..| ::.:.||.|.......|||
Human  2016 YCPQFDAIDELLTGREHLYLYARLRGV-------PAEEIEKVANWSIKSLGLTVYADCLAGTYSG 2073

  Fly  1395 GTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCN 1459
            |.||||..|:|:||.|.||||||||||:||.:||.||..|.....:.|.||||||||:|||.||.
Human  2074 GNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHSMEECEALCT 2138

  Fly  1460 RLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEM-NVSTITGTLKSEFPGLELRESHA 1521
            |||||..|.|:|:..|..||..  .|:.:.:|:|:..:..: :::.:....:..|||...||.|.
Human  2139 RLAIMVKGAFRCMGTIQHLKSKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQRERHY 2203

  Fly  1522 GTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQSTSRQT 1586
            ..|.:.||:       ||:.:|.:..|..:.|.|:.:|||.:.||:.:|:.|   ||.|:.|...
Human  2204 NMLQFQVSS-------SSLARIFQLLLSHKDSLLIEEYSVTQTTLDQVFVNF---AKQQTESHDL 2258

  Fly  1587 SVQRR 1591
            .:..|
Human  2259 PLHPR 2263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	36/151 (24%)
		CcmA	460..767	CDD:224054	123/351 (35%)
		ABC_subfamily_A	461..679	CDD:213230	94/221 (43%)
		ABC2_membrane_3	<937..1117	CDD:289468	45/208 (22%)
		ABC_subfamily_A	1255..1479	CDD:213230	103/226 (46%)
		drrA	1262..1573	CDD:130256	127/316 (40%)
ABCA4	NP_000341.2	rim_protein	1..2272	CDD:130324	459/1760 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..911		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1284..1345		10/63 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148370
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.660