DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eato and ABCA5

DIOPT Version :10

Sequence 1:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster
Sequence 2:NP_061142.2 Gene:ABCA5 / 23461 HGNCID:35 Length:1642 Species:Homo sapiens


Alignment Length:1752 Identity:413/1752 - (23%)
Similarity:708/1752 - (40%) Gaps:343/1752 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 PLFFVF-------LRKNLLY----------LQRNLLPLLLICSGFAGV--LTAYLHWSVK----P 48
            ||||:|       :..|..|          :.:..|..|::  |:..|  :|:.:...|.    |
Human    39 PLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLIL--GYTPVTNITSSIMQKVSTDHLP 101

  Fly    49 VLHQINQFEAKNEMVLRELYFPGNELDYIYYSPISPNVEDIMDLLRVDLGIIPERLRPNNNSFEM 113
            .:....::..:.||:...|..|.|.:..::...:|..:....|::.|.               .:
Human   102 DVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVS---------------SI 151

  Fly   114 QLEMEQQCRGSCFAIDFHRVPNRGSDRKFRYSLSSNQMRISPRKRFVNDEEIYHQIDDDDYIRSG 178
            .::....|..||.|.                                            .|..||
Human   152 YMDSRAGCSKSCEAA--------------------------------------------QYWSSG 172

  Fly   179 FLSLQHILDKQYMKYQ---ELGKDFE---VVVSSMPNMEVISMDSHRLTYFGTLCSILFNVVLLS 237
            |..||..:|...::.:   .|.|:.|   .|:  |....|:.:|:     |.....:::.|:..|
Human   173 FTVLQASIDAAIIQLKTNVSLWKELESTKAVI--MGETAVVEIDT-----FPRGVILIYLVIAFS 230

  Fly   238 SF----VVPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYT-------LLMIFVLVVAYLY 291
            .|    .:..|.||:..:||||.::.    |:...|:|...:.||       |||..:...:.|:
Human   231 PFGYFLAIHIVAEKEKKIKEFLKIMG----LHDTAFWLSWVLLYTSLIFLMSLLMAVIATASLLF 291

  Fly   292 KALGSICFAYVAVLFLLYILSTMSYAYLISICFHSVFYAKIGGLAMLIIPYAFSF-------VRS 349
            ....||   .:.:||.||.||::.:|.:::..|..   :|..|:....:..||.|       :.|
Human   292 PQSSSI---VIFLLFFLYGLSSVFFALMLTPLFKK---SKHVGIVEFFVTVAFGFIGLMIILIES 350

  Fly   350 WATSLA--FVCFSTNTFLEGLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYVVLVFQSFL 412
            :..||.  |..|...||:.|:      :......:|.....|..:.:....:....::|...|..
Human   351 FPKSLVWLFSPFCHCTFVIGI------AQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIF 409

  Fly   413 YAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRN------------------------EYTT 453
            |.:|..||..|.||..||:|...:||.|..:.|.:||                        |:. 
Human   410 YVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEELSEGNVNGNISFSEIIEPVSSEFV- 473

  Fly   454 TPRGTHAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDS 518
               |..||.|:.:.|.::....:.....||:..|...:||.||||:|.||:|:||::.||.|...
Human   474 ---GKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSD 535

  Fly   519 GKIIVCSER-----DVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLK 578
            |...:...|     ::...|.:||.|||..:....:|..::|...|.::|...::......:.|.
Human   536 GFASIYGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLL 600

  Fly   579 KLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKA 643
            .|.:...::...|.||||.||:||||||:.||.||::||||::|:|..||..:|::|...:..:.
Human   601 DLDMQTIKDNQAKKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRV 665

  Fly   644 VLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEIMEIIHH 708
            .:.:||:|:||::|.|...:::.|.|:.:||.:.||.|.||||||.:.|:.:.:.| .:..::..
Human   666 TVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCATE-SLSSLVKQ 729

  Fly   709 FVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLR--CAGE 771
            .:|.|.:|...:..:...||:...:.|:.:...|::.| .||:.:..::.|:||||||:  ...|
Human   730 HIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHS-NLGVISYGVSMTTLEDVFLKLEVEAE 793

  Fly   772 QDQVD----------------TPDGSRNDAPLLAHYKRLQDHPPHRGLFQLWMAVFY--KKWTFI 818
            .||.|                :.|.......:|:..|...     .....||....|  .|:.|.
Human   794 IDQADYSVFTQQPLEEEMDSKSFDEMEQSLLILSETKAAL-----VSTMSLWKQQMYTIAKFHFF 853

  Fly   819 -----SNEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLKLSQMGSGVIYVHNPTGHHAH 878
                 |......|::|.|.|.......||.|:.    ....:|:||..    .:|...| |...|
Human   854 TLKRESKSVRSVLLLLLIFFTVQIFMFLVHHSF----KNAVVPIKLVP----DLYFLKP-GDKPH 909

  Fly   879 LEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQRDNLADFLEQVIGIIDMYGGGRGTSDTP-- 941
            ..:           |:..:.....:|:.        |.::.|..|.| ::.|.......|..|  
Human   910 KYK-----------TSLLLQNSADSDIS--------DLISFFTSQNI-MVTMINDSDYVSVAPHS 954

  Fly   942 -TIEIFYSGNRY-----------HSSVELINLVDSAMLKLGRPESEIDTTYVPIRRFVSDISPSR 994
             .:.:.:|...|           :|...|:|::.:..|........|.....|..:.::|| ..:
Human   955 AALNVMHSEKDYVFAAVFNSTMVYSLPILVNIISNYYLYHLNVTETIQIWSTPFFQEITDI-VFK 1018

  Fly   995 LEYYAVIVPIGMFFFMF--YFISLPFREYANGFK-------QLQTMSRFTYWFAHFTFDM-LILI 1049
            :|.|.....:|:.....  ||.    .|.|...|       :|..:....||......|: |..|
Human  1019 IELYFQAALLGIIVTAMPPYFA----MENAENHKIKAYTQLKLSGLLPSAYWIGQAVVDIPLFFI 1079

  Fly  1050 FVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLLLMLIV 1114
            .:.:.|.||.:.......||...| .:|..:..|..|.:...|.....||.|.....:...:..|
Human  1080 ILILMLGSLLAFHYGLYFYTVKFL-AVVFCLIGYVPSVILFTYIASFTFKKILNTKEFWSFIYSV 1143

  Fly  1115 SAIAPL-ITS-----SNAAAMKLHETKIAFLCFLPDFNL--------NHQFRIINENFITRRHPA 1165
            :|:|.: ||.     ....|..||   .||...:|.:.|        ...::.:.:|.       
Human  1144 AALACIAITEITFFMGYTIATILH---YAFCIIIPIYPLLGCLISFIKISWKNVRKNV------- 1198

  Fly  1166 LIKGLISQDTFFAYATAVGVMVMAFFTIVL--------EHKYLRRRIHDGIWEWAFQRKKYNSTG 1222
                    ||:..:......::..:...||        |.||..|.|....:......|..|.  
Human  1199 --------DTYNPWDRLSVAVISPYLQCVLWIFLLQYYEKKYGGRSIRKDPFFRNLSTKSKNR-- 1253

  Fly  1223 TLPSTPIS--EIDDCAREEKRVTDLI------KDPLNDHSLIVHNLRKRYGD-----------KL 1268
            .||..|.:  |.:|...|..:|.:|:      :.|    |::|.||.|.|.|           |:
Human  1254 KLPEPPDNEDEDEDVKAERLKVKELMGCQCCEEKP----SIMVSNLHKEYDDKKDFLLSRKVKKV 1314

  Fly  1269 AVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHE----LKYREYF 1329
            |...:||...:||..||||.|||||::...::..::....|.:.:........|    ||   ..
Human  1315 ATKYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTSGQVFLGDYSSETSEDDDSLK---CM 1376

  Fly  1330 GYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSG 1394
            |||||.:.|....|.::.......::|:|      .:..||.:......:.|.::.:..|:....
Human  1377 GYCPQINPLWPDTTLQEHFEIYGAVKGMS------ASDMKEVISRITHALDLKEHLQKTVKKLPA 1435

  Fly  1395 GTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKD-FQGKDRTVVLTSHSMDECEELC 1458
            |.||||..|::|:|.|.:.|||||:||:||.:::.:|:.|:. |:.:.|..:||:|.|:|.|.:|
Human  1436 GIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAILTTHYMEEAEAVC 1500

  Fly  1459 NRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGTLKSEFPGLELRESHA 1521
            :|:|||..|:.:|:..:..||..  .|:.:::|:| |....:.|..:...::..||....:||.:
Human  1501 DRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLK-DWIENLEVDRLQREIQYIFPNASRQESFS 1564

  Fly  1522 GTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQSTS 1583
            ..|.|.:..::...|..|.||:.|.    :.:..:.:||.::.|||.:|::..:|.:.:..|
Human  1565 SILAYKIPKEDVQSLSQSFFKLEEA----KHAFAIEEYSFSQATLEQVFVELTKEQEEEDNS 1622

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EatoNP_001036360.1 rim_protein <169..1591 CDD:130324 387/1567 (25%)
ABCA5NP_061142.2 rim_protein <84..1618 CDD:130324 402/1699 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1249..1268 6/20 (30%)

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