DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and Abca16

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	XP_006507746.1	Gene:	Abca16 / 233810	MGIID:	2388711	Length:	1679	Species:	Mus musculus

Alignment Length:	1762	Identity:	434/1762 - (24%)
Similarity:	757/1762 - (42%)	Gaps:	291/1762 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VFLRKNLLYLQRNLLP-------------LLLICSGFAGV-LTAYLHWSVKPVLHQINQFEAKNE 61
            |.|.||....:|.::.             :|||......: :....|::.:|:....:..:...|
Mouse    11 VLLWKNFTLKKRQIISTSAELLAALLFVIMLLIFRALTDMNIAGPYHFTAQPIAIMPSFIKDAQE 75

  Fly    62 MVLRELYFPGNELDYIYYSPISPNVEDIMDLLRVDLGIIPERLRPNNNSFEMQLEMEQQCRGSCF 126
            ..|  :|.| :|:|.     :...:||:...|...:.:   |..|:...||..:..:...:....
Mouse    76 WEL--VYIP-SEIDV-----VREIIEDVKRNLNTTIKV---RGFPSEAEFEEYILFDNMSQKVLA 129

  Fly   127 AIDFHRVPNRGSDRKFRYSLSSNQMRISPRKRFVNDEEI-------------------------- 165
            ||.|        |..|:.......:::....|||..:..
Mouse   130 AIVF--------DCGFKNKSDPLPLQVKYHLRFVGAQRTIWWPDKLGWKTRLLFPNHPSIRPRNP 186

  Fly   166 -YHQIDDDDYIRSGFLSLQHILDKQYMKYQE--LGK----DFEVVVSSMPNMEVISMDSH---RL 220
             |.......||:.|||::||.|||..|.|.|  .||    :.:.|:...|      ..||   :|
Mouse   187 NYLDGGSPGYIKEGFLAVQHALDKSIMLYHESSAGKKLFDEIDTVIQRFP------YPSHPQDKL 245

  Fly   221 TYFGTLCSILFNVVLLSSFVV----PFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYTLLM 281
            .:..:....|..:::.||.|:    ..|.||:..|||:..::...:::..:.:|...|..|.:::
Mouse   246 LWISSPFIPLMFILMFSSIVLSIMRSIVFEKEKRLKEYQLIMGLRNWIIWIGYFFTFFPLYVIII 310

  Fly   282 IFVLVVAYL---------YKALGSICFAYVAVLFLLYILSTMSYAYLISICFHSV-FYAKIGGLA 336
            :.:.::.::         |    |.| :::.|....|.::::.:|:::|..|... ..|..|.|.
Mouse   311 LLICILLFVQIVEEPILRY----SDC-SFIFVFLTCYAIASICFAFMVSTFFSKTRLAASAGNLL 370

  Fly   337 MLIIPYAFSFVRSW-----ATSLAFVCFSTNTFLE-GLDI---------------FQTFSNKRKN 380
            .....:.::|:..:     .|:....|.|.|..|. |::|               ..|.:|...|
Mouse   371 FFASFFPYNFISEYYGMLNLTTKITACLSANVALALGINILIKLEIQEIGVKWHNLWTPANLEDN 435

  Fly   381 REFGAVDVFRVIKSNSSTMFSVYV--VLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFL----- 438
            ..||                  |:  :|:|.:|||:::..|:..||||..|:.:|.:|||
Mouse   436 LNFG------------------YMLGMLLFDAFLYSLVTWYVEAVFPGQCGVPQPWYFFLMRSYW 482

  Fly   439 --DPKTYMKRQRNEYTTTP--------------RGTHAIIITELCKKFQTSKRDTLISDNLNMTI 487
              .||  :::...|...||              .|.|   |..|.|:|:...    ..:||::.|
Mouse   483 FGKPK--IRKTTEEAKCTPIVHNCYEAEPPNLEAGIH---IMHLHKEFKNKP----AVNNLSLNI 538

  Fly   488 NNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYM 549
            ...::|||||||||||||.::::.|......|:..:..   ..::...|..:||||||.:....:
Mouse   539 YEGQVTVLLGHNGAGKTTTLSVLTGRFAATRGEAYINGYNISDNMIEVRKDLGFCPQHDLLFDDL 603

  Fly   550 TCHQHLEFFAQLRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIV 614
            |..:||.|:..::|..::...:..|..|....|.:..:....:.|||::|:||:.:|:...:|:|
Mouse   604 TLSEHLFFYCMVKGIPQNINCEEIDRMLSAFNLQENYHTLSGSASGGVRRKLSIVLALMAGSKVV 668

  Fly   615 ILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELK 679
            ||||||||:|..|||..||||.:.:..:.:|:|||||:||:||||.:.|:..|.|...||.:.||
Mouse   669 ILDEPSSGMDPVSRRATWDILQHYKHNRTILLTTHYMDEADVLGDRVAIMVRGTLHCCGSSVFLK 733

  Fly   680 RKSGIGYRLKLEINDFTSREVEIMEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLET 744
            :..|.||.:.:|...:...: .|:.:|...||.|.:.|.:...:...||..|.:.|..:...||.
Mouse   734 QIYGAGYHIVMEKQQYCDVD-NIIAMIQQHVPGAVLENNIENELSFILPKKYVSRFETLFTELEM 797

  Fly   745 ESKELGIHTISMTDTSLEDVFLRC------------------------AGEQDQVDTP-DGSRND 784
            ..|.|||.:...:.|::|:||::.                        ..||..|:.| :.|:.:
Mouse   798 RQKALGIASFGASITTMEEVFVKVNKLATPQKSIQTIQPYYLAYRKMRQDEQQNVNMPINYSKPN 862

  Fly   785 APLLAHYKRLQDH---PPHRGLFQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGAILVMHAM 846
            .|.|:....::.:   |.:|   |.:.::|.|:..|||..|.:.|:.:.:..|.....:|.:|.
Mouse   863 FPYLSEIATVKFNTGVPLYR---QQFYSLFIKRALFISRNWKFMLLQIIVVMVVTTYLLLALHL- 923

  Fly   847 SLVENEEALP---LKLSQMGSGVIYVHNPTGHHAHLEQQLRQQIELNGITAKTMHLRGSNDVKNE 908
                |...:|   |.||..|..:  |...|..::.|...|.:.:.: .:.:|..:||......|:
Mouse   924 ----NNNDIPERELNLSHYGRTI--VPYSTSGNSDLALNLTKNLNI-FLKSKNQNLRKIRGDMND 981

  Fly   909 SLDLQRDNLADFLEQVIGIIDMYGGGRGTSDTPTIEIFYSGNRYHSSVELINLVDSAM-LKLGRP 972
            .: |:..:...|....:.|       :...:...:.||::...|||....::::|:.: :.|..|
Mouse   982 YI-LKNKDCHTFCLVALSI-------KVERNKTVLTIFFNNEAYHSPAISLSILDNILFMTLSGP 1038

  Fly   973 ESEIDTTY---VPIRRFVSDISP-SRLEY-----YAVIVPIGMFFFMFYFISLPFREYANGFKQL 1028
            ::.| |.:   .|:..:.|:|.| :.|:.     :.:.|.:|.|...      ...|..:..|.:
Mouse  1039 DASI-TVFNKPQPLPHYGSNIVPVNGLQIVQCLAFGISVVVGSFSIQ------TVTERTSQAKHI 1096

  Fly  1029 QTMSR---FTYWFAHFTFDMLILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPI 1090
            |.::.   .|||.:....|::...|.|..|.::..................:|....||...:|:
Mouse  1097 QFLTGVCVHTYWLSALLCDLIFFFFACCVLLAIFKFCQLEAFVVHYNFLDTILIFMLYGWCVVPL 1161

  Fly  1091 LYALGNNFKSIS------TISTYLLLMLIVSAIAPLITSSNAAAMKLHETKIAFLCFLPDFNLNH 1149
            .|.....|.|.:      |:..|...|..:.....:....|.....:|....|.|..||.:||..
Mouse  1162 TYIASFLFNSSTAAYIKITLFNYFSTMFSIIIYTIIQFYGNDFPNFVHILIRAILMALPSYNLAM 1226

  Fly  1150 QFRIINENFITRRHPAL-IKGL-------ISQDTFFAYAT-AVGVMVMAFFTIVLEHKYLRRRIH 1205
            ......:::..:|..|. .|.:       .:|:..:.:.. .:|..::...||.|....|...:.
Mouse  1227 SISKYFDDYEVKRLCAREFKSIYLDCSDPYTQNNVYGFGEHGIGKFLITLATIGLVFLLLLLSLE 1291

  Fly  1206 D---GIWEWAFQ----------RKKYNSTGTLPSTPISEIDDCAREEKRVTDLIKDPLNDHSLIV 1257
            .   .:..:.|:          ||..|:..:...|...|.:|..:|:.:|..|:. .|.:..|::
Mouse  1292 SVSCSLKSFVFRNIIFYFYNKLRKGRNAIPSNQRTKEDEDEDIKKEKGKVFTLLL-RLQNTPLLL 1355

  Fly  1258 HNLRKRYGD---KLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIR 1319
            :.:.|.|..   ..||..:|....:.|||||||:||||||:||:|:.....:..|...|.|..:.
Mouse  1356 NEVTKIYFKCPVVKAVKNISLVVKKSECFGLLGLNGAGKTTTFKMLTGEETITSGIAFIDGNSVT 1420

  Fly  1320 EHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYWLEKMHLTKY 1384
            ....|.|...|||||.:::...||..:.|...|.|.|:..:      ...|:|:.:|..:||...
Mouse  1421 RTPRKIRSRIGYCPQTESVLNHMTGRESLVMYARLWGVLEQ------DINEYVEAFLHSVHLEPI 1479

  Fly  1385 QKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSH 1449
            ....:..||.|:||:|..|:|::|..::|.||||:.|:||:::..||:.|.......:.:::|||
Mouse  1480 ADQFIHTYSAGSKRRLSTAIALMGKSSVVFLDEPSIGMDPVAQHLLWETITWICKTGKAIIITSH 1544

  Fly  1450 SMDECEELCNRLAIMAHGKFKCLNNICALKRLSG----FTIKLKMKADTETEMNVSTITGTLKSE 1510
            .|:|||.||.|||||..|:|.||.....:::..|    .|:::.:..|   |..|......:|..
Mouse  1545 RMEECEALCTRLAIMVKGRFTCLGTPQHVRKRFGHVYTLTVRINIAKD---EDKVEEFKNFIKVT 1606

  Fly  1511 FPG-LELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFE 1574
            ||| ::.:|.| ||:.|::.::|  :.|..||.|.||   .::...:.||||...|||.|||.|.
Mouse  1607 FPGNIKFQEFH-GTIGYYIPSKE--IYWGKVFAILEE---AKVLFKLEDYSVKRVTLEQIFLTFA 1665

  Fly  1575 REAKSQS 1581
            ...|.::
Mouse  1666 NTDKMRT 1672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	27/154 (18%)
		CcmA	460..767	CDD:224054	105/309 (34%)
		ABC_subfamily_A	461..679	CDD:213230	79/220 (36%)
		ABC2_membrane_3	<937..1117	CDD:289468	38/198 (19%)
		ABC_subfamily_A	1255..1479	CDD:213230	81/226 (36%)
		drrA	1262..1573	CDD:130256	111/318 (35%)
Abca16	XP_006507746.1	rim_protein	<196..1665	CDD:130324	400/1549 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838480
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760