DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eato and Abca5

DIOPT Version :9

Sequence 1:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster
Sequence 2:NP_671752.2 Gene:Abca5 / 217265 MGIID:2386607 Length:1642 Species:Mus musculus


Alignment Length:1758 Identity:412/1758 - (23%)
Similarity:726/1758 - (41%) Gaps:340/1758 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LRKNLLY--------LQRNLLPLLLICSGFAGVLTAYLHWSV-KPVLHQINQFEAKNEMVLREL- 67
            |.||.|.        :|..|.||.            :|.|.: ..::|...::|..:::.|..: 
Mouse    18 LLKNYLIKCRTKKSSVQEILFPLF------------FLFWLILVSMMHPNKKYEEVSDIELSPMD 70

  Fly    68 -YFPGNELDYIYYSPISPNVEDIMDLLRVDLGIIPERLRPNNNSFEMQLEMEQQCRGSCF-AIDF 130
             :...|.:  :.|:|::.....||.  ||....:|:.:.....:.|.:|......:.|.| .:.|
Mouse    71 KFSLSNVI--LGYTPVTNITSSIMQ--RVSTDHLPKVIVTEEYANEKELVAASLSKSSNFVGVVF 131

  Fly   131 HRVPNRGSDRKFRYSLSSNQMRISPR-----KRFVNDEE-IYHQIDDDDYIRSGFLSLQHILDKQ 189
            .             ...|.::|..|.     ..::|..| .....|...|...||..||..:|..
Mouse   132 K-------------DTMSYELRFFPEMIPVSSIYMNSREGCSKTCDAAQYWSLGFTVLQASIDAA 183

  Fly   190 YMK-------YQELGKDFEVVVSSMPNMEVISMDSHRLTYFGTLCSILFNVVLLSSF----VVPF 243
            .::       :.||.....|:   |....|:.:|:     |.....:::.|:..|.|    .:..
Mouse   184 IIQLKTNVSVWSELESTKAVI---MGEAAVVEIDT-----FPRGVILIYLVIAFSPFGYFLAIHI 240

  Fly   244 VEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCY-------TLLMIFVLVVAYLYKALGSICFAY 301
            |.||:..|||||.::.    |:...|:|...:.|       :|||..:...:.|:....||   .
Mouse   241 VAEKEKKLKEFLKIMG----LHDTAFWLSWVLLYASLIFLMSLLMAVIATASSLFPQSSSI---V 298

  Fly   302 VAVLFLLYILSTMSYAYLISICFH--------SVFYAKIGGLAMLIIPYAFSFVRS--WATSLAF 356
            :.:||.||.||::.:|.:::..|.        ..|...:.|...|:|....||.||  |..|...
Mouse   299 IFLLFFLYGLSSVFFALMLTPLFKKSKHVGVVEFFVTVVFGFVGLLIVLIESFPRSLVWLFSPLC 363

  Fly   357 VCFSTNTFLEGLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFS-----------VYVVLVFQS 410
            .|    .||                 .|...|..:...|...:||           ..::|...|
Mouse   364 QC----AFL-----------------IGIAQVMHLEDFNEGALFSNLTEGPYPLIITIIMLALDS 407

  Fly   411 FLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRN------------------------EY 451
            ..|.:|..||..|.||..||:|...:||.|..:.|.:||                        |:
Mouse   408 VFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKNKRNYKELSEGNINGNISLNEIVEPVSSEF 472

  Fly   452 TTTPRGTHAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPK 516
            .    |..||.|:.:.|.::....:.....||:..|...:||.||||:|.||:|:||::.||.|.
Mouse   473 I----GKEAIRISGIQKSYRKKTENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPP 533

  Fly   517 DSGKIIVCSER-----DVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEK 576
            ..|...:...|     ::...|.:||.|||..:....:|..::|...|.::|...::......:.
Mouse   534 SDGFASIYGHRVSEIDEMFEARKMIGICPQSDINFDVLTVEENLSILASIKGIPANNIIQEVQKV 598

  Fly   577 LKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKE 641
            |..|.:...::...|.||||.||:||:|||:.||.||::||||::|:|..||..:|::|...:..
Mouse   599 LLDLDMQAIKDNQAKKLSGGQKRKLSVGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKAN 663

  Fly   642 KAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEIMEII 706
            :..:.:||:|:||::|.|...:::.|.|:.:||.:.||.|.||||||.:.|:.:.:.| .:..::
Mouse   664 RVTVFSTHFMDEADILADRKAVISQGMLKCVGSSIFLKSKWGIGYRLSMYIDRYCATE-SLSSLV 727

  Fly   707 HHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLR--CA 769
            ...:|.|.:|...:..:...||:...:.|:.:...|:..| .||:.:..::.|:||||||:  ..
Mouse   728 RQHIPAAALLQQNDQQLVYSLPFKDMDKFSGLFSALDIHS-NLGVISYGVSMTTLEDVFLKLEVE 791

  Fly   770 GEQDQVD------TPDGSRNDAP----------LLAHYKRLQDHPPHRGLFQLW--MAVFYKKWT 816
            .|.||.|      .|.....|:.          :|:..|     ........||  ......|:.
Mouse   792 AEIDQADYSVFTQQPREEETDSKSFDEMEQSLLILSETK-----ASSVSTMSLWKQQVSTIAKFH 851

  Fly   817 FIS----NEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLKLSQMGSGVIYVHNPTGHHA 877
            |:|    ::.:..:::|.:.|   |...:.|..:........:|:||..    .:|...| |...
Mouse   852 FLSLKRESKSVRAVLLLLLIF---FAVQIFMFFLHHSFKNAVVPIKLVP----DLYFLKP-GDKP 908

  Fly   878 H-----LEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQRDNLADFL-----EQVIGIIDMYG 932
            |     |..|.....::||:.....|         :::.:...|.:|::     ...:.::    
Mouse   909 HKYKTSLLLQNSTDSDINGLIEFFAH---------QNIMVAMFNDSDYVSAAPHSAALNVV---- 960

  Fly   933 GGRGTSDTPTIEIFYSGNRYHSSVELINLVDSAMLKLGRPESEIDTTYVPIRRFVSDISPSRLEY 997
              |...|.....:|.|...|...| ::|::.:..|........|.|...|..:.::|| ..::|.
Mouse   961 --RSEKDYVFSAVFNSTMVYCLPV-MMNIISNYYLYHLNVTEAIQTWSTPFIQEITDI-VFKIEL 1021

  Fly   998 YAVIVPIGMFFFMF--YFISLPFREYANGFK-------QLQTMSRFTYWFAHFTFDM----LILI 1049
            |.....:|:.....  ||.    .|.|...|       :|..:....||......|:    ::||
Mouse  1022 YFQAALLGIIVTAMPPYFA----MENAENHKIKAYTQLKLSGLLPSAYWVGQAVVDIPLFFVVLI 1082

  Fly  1050 FVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLLLMLIV 1114
            .:..:||:....:    .:..|:...:|..:..|..|.:...|.....||.|.....:...:..|
Mouse  1083 LMLGSLFAFHHGL----YFYPAKFLAVVFCLIAYVPSVILFTYIASFTFKKILNTKEFWSFIYSV 1143

  Fly  1115 SAIAPLITSSNAAAMKLHETKI---AFLCFLPDFNLNHQFRIINENFITRRHPAL------IKGL 1170
            :|:|.:..:.....::...|.:   .|...:|.:                  |.|      |||.
Mouse  1144 TALACVAITETTFFLQYAVTAVFHYTFCIAIPIY------------------PLLGCLISFIKGS 1190

  Fly  1171 -----ISQDTFFAYATAVGVMVMAF-----FTIVLEHKYLRRRIHDG--IWEWAFQR-------- 1215
                 .:::|:..:...:..::|.:     :..:|:|   ..:||.|  |.:..|.|        
Mouse  1191 WKNMPKNENTYNPWDRLLVAVIMPYLQCILWIFLLQH---YEKIHGGRSIRKDPFFRALSQKAKN 1252

  Fly  1216 KKYNSTGTLPSTPIS--EIDDCAREEKRVTDLI------KDPLNDHSLIVHNLRKRYGD------ 1266
            ||:      |..||:  |.:|...|..:|.:|:      :.|    :::|.||.|.|.|      
Mouse  1253 KKF------PEPPINEDEDEDVKAERLKVKELMGCQCCEEKP----AIMVCNLHKEYDDKKDFLH 1307

  Fly  1267 -----KLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYR 1326
                 |:|...:||...:||..||||.|||||::....:..::....|.|.:  .|...|..:..
Mouse  1308 SRKTTKVATKYISFCVKKGEILGLLGPNGAGKSTVINTLVGDVEPTSGKIFL--GDYGSHSSEDD 1370

  Fly  1327 E---YFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYWLEKMHLTKYQKVQ 1388
            |   ..|||||.:.|...:|.::.......::|:|      |...||.:....:.:.|.::.:..
Mouse  1371 ESIKCMGYCPQTNPLWPDLTLQEHFEIYGAVKGMS------PGDMKEVISRITKALDLKEHLQKT 1429

  Fly  1389 VRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKD-FQGKDRTVVLTSHSMD 1452
            |:....|.||||..|::|:|.|.:.|||||:||:||.:::.:|:.|:. |:.|.|..:||:|.|:
Mouse  1430 VKKLPAGIKRKLCFALSMLGNPQVTLLDEPSTGMDPRAKQHMWRAIRTAFKNKKRAALLTTHYME 1494

  Fly  1453 ECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGTLKSEFPGLE 1515
            |.|.:|:|:|||..|:.:|:..:..||..  .|:.:::|:| |....:.:..:...::..||...
Mouse  1495 EAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLK-DWIENLEIDRLQREIQYIFPNAS 1558

  Fly  1516 LRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQ 1580
            .:||.:..|.:.:..::...|..|..|:.|.    :.:..:.:||.::.|||.:|::..:|.:.:
Mouse  1559 RQESFSSILAFKIPKEDVQSLSQSFAKLEEA----KRTFAIEEYSFSQATLEQVFVELTKEQEEE 1619

  Fly  1581 STS 1583
            ..|
Mouse  1620 DNS 1622

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EatoNP_001036360.1 ABC2_membrane_3 <209..347 CDD:289468 37/156 (24%)
CcmA 460..767 CDD:224054 100/311 (32%)
ABC_subfamily_A 461..679 CDD:213230 72/222 (32%)
ABC2_membrane_3 <937..1117 CDD:289468 37/192 (19%)
ABC_subfamily_A 1255..1479 CDD:213230 76/238 (32%)
drrA 1262..1573 CDD:130256 94/327 (29%)
Abca5NP_671752.2 rim_protein <84..1618 CDD:130324 395/1672 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838452
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.650

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