DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eato and Abca5

DIOPT Version :10

Sequence 1:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster
Sequence 2:NP_671752.2 Gene:Abca5 / 217265 MGIID:2386607 Length:1642 Species:Mus musculus


Alignment Length:1758 Identity:412/1758 - (23%)
Similarity:726/1758 - (41%) Gaps:340/1758 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 LRKNLLY--------LQRNLLPLLLICSGFAGVLTAYLHWSV-KPVLHQINQFEAKNEMVLREL- 67
            |.||.|.        :|..|.||.            :|.|.: ..::|...::|..:::.|..: 
Mouse    18 LLKNYLIKCRTKKSSVQEILFPLF------------FLFWLILVSMMHPNKKYEEVSDIELSPMD 70

  Fly    68 -YFPGNELDYIYYSPISPNVEDIMDLLRVDLGIIPERLRPNNNSFEMQLEMEQQCRGSCF-AIDF 130
             :...|.:  :.|:|::.....||.  ||....:|:.:.....:.|.:|......:.|.| .:.|
Mouse    71 KFSLSNVI--LGYTPVTNITSSIMQ--RVSTDHLPKVIVTEEYANEKELVAASLSKSSNFVGVVF 131

  Fly   131 HRVPNRGSDRKFRYSLSSNQMRISPR-----KRFVNDEE-IYHQIDDDDYIRSGFLSLQHILDKQ 189
            .             ...|.::|..|.     ..::|..| .....|...|...||..||..:|..
Mouse   132 K-------------DTMSYELRFFPEMIPVSSIYMNSREGCSKTCDAAQYWSLGFTVLQASIDAA 183

  Fly   190 YMK-------YQELGKDFEVVVSSMPNMEVISMDSHRLTYFGTLCSILFNVVLLSSF----VVPF 243
            .::       :.||.....|:   |....|:.:|:     |.....:::.|:..|.|    .:..
Mouse   184 IIQLKTNVSVWSELESTKAVI---MGEAAVVEIDT-----FPRGVILIYLVIAFSPFGYFLAIHI 240

  Fly   244 VEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCY-------TLLMIFVLVVAYLYKALGSICFAY 301
            |.||:..|||||.::.    |:...|:|...:.|       :|||..:...:.|:....||   .
Mouse   241 VAEKEKKLKEFLKIMG----LHDTAFWLSWVLLYASLIFLMSLLMAVIATASSLFPQSSSI---V 298

  Fly   302 VAVLFLLYILSTMSYAYLISICFH--------SVFYAKIGGLAMLIIPYAFSFVRS--WATSLAF 356
            :.:||.||.||::.:|.:::..|.        ..|...:.|...|:|....||.||  |..|...
Mouse   299 IFLLFFLYGLSSVFFALMLTPLFKKSKHVGVVEFFVTVVFGFVGLLIVLIESFPRSLVWLFSPLC 363

  Fly   357 VCFSTNTFLEGLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFS-----------VYVVLVFQS 410
            .|    .||                 .|...|..:...|...:||           ..::|...|
Mouse   364 QC----AFL-----------------IGIAQVMHLEDFNEGALFSNLTEGPYPLIITIIMLALDS 407

  Fly   411 FLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRN------------------------EY 451
            ..|.:|..||..|.||..||:|...:||.|..:.|.:||                        |:
Mouse   408 VFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKNKRNYKELSEGNINGNISLNEIVEPVSSEF 472

  Fly   452 TTTPRGTHAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPK 516
            .    |..||.|:.:.|.::....:.....||:..|...:||.||||:|.||:|:||::.||.|.
Mouse   473 I----GKEAIRISGIQKSYRKKTENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPP 533

  Fly   517 DSGKIIVCSER-----DVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEK 576
            ..|...:...|     ::...|.:||.|||..:....:|..::|...|.::|...::......:.
Mouse   534 SDGFASIYGHRVSEIDEMFEARKMIGICPQSDINFDVLTVEENLSILASIKGIPANNIIQEVQKV 598

  Fly   577 LKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKE 641
            |..|.:...::...|.||||.||:||:|||:.||.||::||||::|:|..||..:|::|...:..
Mouse   599 LLDLDMQAIKDNQAKKLSGGQKRKLSVGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKAN 663

  Fly   642 KAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEIMEII 706
            :..:.:||:|:||::|.|...:::.|.|:.:||.:.||.|.||||||.:.|:.:.:.| .:..::
Mouse   664 RVTVFSTHFMDEADILADRKAVISQGMLKCVGSSIFLKSKWGIGYRLSMYIDRYCATE-SLSSLV 727

  Fly   707 HHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLR--CA 769
            ...:|.|.:|...:..:...||:...:.|:.:...|:..| .||:.:..::.|:||||||:  ..
Mouse   728 RQHIPAAALLQQNDQQLVYSLPFKDMDKFSGLFSALDIHS-NLGVISYGVSMTTLEDVFLKLEVE 791

  Fly   770 GEQDQVD------TPDGSRNDAP----------LLAHYKRLQDHPPHRGLFQLW--MAVFYKKWT 816
            .|.||.|      .|.....|:.          :|:..|     ........||  ......|:.
Mouse   792 AEIDQADYSVFTQQPREEETDSKSFDEMEQSLLILSETK-----ASSVSTMSLWKQQVSTIAKFH 851

  Fly   817 FIS----NEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLKLSQMGSGVIYVHNPTGHHA 877
            |:|    ::.:..:::|.:.|   |...:.|..:........:|:||..    .:|...| |...
Mouse   852 FLSLKRESKSVRAVLLLLLIF---FAVQIFMFFLHHSFKNAVVPIKLVP----DLYFLKP-GDKP 908

  Fly   878 H-----LEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQRDNLADFL-----EQVIGIIDMYG 932
            |     |..|.....::||:.....|         :::.:...|.:|::     ...:.::    
Mouse   909 HKYKTSLLLQNSTDSDINGLIEFFAH---------QNIMVAMFNDSDYVSAAPHSAALNVV---- 960

  Fly   933 GGRGTSDTPTIEIFYSGNRYHSSVELINLVDSAMLKLGRPESEIDTTYVPIRRFVSDISPSRLEY 997
              |...|.....:|.|...|...| ::|::.:..|........|.|...|..:.::|| ..::|.
Mouse   961 --RSEKDYVFSAVFNSTMVYCLPV-MMNIISNYYLYHLNVTEAIQTWSTPFIQEITDI-VFKIEL 1021

  Fly   998 YAVIVPIGMFFFMF--YFISLPFREYANGFK-------QLQTMSRFTYWFAHFTFDM----LILI 1049
            |.....:|:.....  ||.    .|.|...|       :|..:....||......|:    ::||
Mouse  1022 YFQAALLGIIVTAMPPYFA----MENAENHKIKAYTQLKLSGLLPSAYWVGQAVVDIPLFFVVLI 1082

  Fly  1050 FVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLLLMLIV 1114
            .:..:||:....:    .:..|:...:|..:..|..|.:...|.....||.|.....:...:..|
Mouse  1083 LMLGSLFAFHHGL----YFYPAKFLAVVFCLIAYVPSVILFTYIASFTFKKILNTKEFWSFIYSV 1143

  Fly  1115 SAIAPLITSSNAAAMKLHETKI---AFLCFLPDFNLNHQFRIINENFITRRHPAL------IKGL 1170
            :|:|.:..:.....::...|.:   .|...:|.:                  |.|      |||.
Mouse  1144 TALACVAITETTFFLQYAVTAVFHYTFCIAIPIY------------------PLLGCLISFIKGS 1190

  Fly  1171 -----ISQDTFFAYATAVGVMVMAF-----FTIVLEHKYLRRRIHDG--IWEWAFQR-------- 1215
                 .:::|:..:...:..::|.:     :..:|:|   ..:||.|  |.:..|.|        
Mouse  1191 WKNMPKNENTYNPWDRLLVAVIMPYLQCILWIFLLQH---YEKIHGGRSIRKDPFFRALSQKAKN 1252

  Fly  1216 KKYNSTGTLPSTPIS--EIDDCAREEKRVTDLI------KDPLNDHSLIVHNLRKRYGD------ 1266
            ||:      |..||:  |.:|...|..:|.:|:      :.|    :::|.||.|.|.|      
Mouse  1253 KKF------PEPPINEDEDEDVKAERLKVKELMGCQCCEEKP----AIMVCNLHKEYDDKKDFLH 1307

  Fly  1267 -----KLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYR 1326
                 |:|...:||...:||..||||.|||||::....:..::....|.|.:  .|...|..:..
Mouse  1308 SRKTTKVATKYISFCVKKGEILGLLGPNGAGKSTVINTLVGDVEPTSGKIFL--GDYGSHSSEDD 1370

  Fly  1327 E---YFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYWLEKMHLTKYQKVQ 1388
            |   ..|||||.:.|...:|.::.......::|:|      |...||.:....:.:.|.::.:..
Mouse  1371 ESIKCMGYCPQTNPLWPDLTLQEHFEIYGAVKGMS------PGDMKEVISRITKALDLKEHLQKT 1429

  Fly  1389 VRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKD-FQGKDRTVVLTSHSMD 1452
            |:....|.||||..|::|:|.|.:.|||||:||:||.:::.:|:.|:. |:.|.|..:||:|.|:
Mouse  1430 VKKLPAGIKRKLCFALSMLGNPQVTLLDEPSTGMDPRAKQHMWRAIRTAFKNKKRAALLTTHYME 1494

  Fly  1453 ECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGTLKSEFPGLE 1515
            |.|.:|:|:|||..|:.:|:..:..||..  .|:.:::|:| |....:.:..:...::..||...
Mouse  1495 EAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLK-DWIENLEIDRLQREIQYIFPNAS 1558

  Fly  1516 LRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQ 1580
            .:||.:..|.:.:..::...|..|..|:.|.    :.:..:.:||.::.|||.:|::..:|.:.:
Mouse  1559 RQESFSSILAFKIPKEDVQSLSQSFAKLEEA----KRTFAIEEYSFSQATLEQVFVELTKEQEEE 1619

  Fly  1581 STS 1583
            ..|
Mouse  1620 DNS 1622

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EatoNP_001036360.1 rim_protein <169..1591 CDD:130324 381/1584 (24%)
Abca5NP_671752.2 rim_protein <84..1618 CDD:130324 395/1672 (24%)

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