DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eato and Abca8a

DIOPT Version :9

Sequence 1:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster
Sequence 2:XP_006533124.3 Gene:Abca8a / 217258 MGIID:2386846 Length:1653 Species:Mus musculus


Alignment Length:1784 Identity:415/1784 - (23%)
Similarity:729/1784 - (40%) Gaps:418/1784 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 FVFLRKNLL---YLQRN-----LLPLLLICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVLRE 66
            :..|.||||   .|:|:     |...|::.|     |..:|.      ||::..|.:..::.|..
Mouse    47 WALLCKNLLRKKRLKRDTFLEFLYTALILLS-----LILFLQ------LHEVYDFSSLPDVDLGR 100

  Fly    67 LYFPGNELDYIYYSPISPNVEDIMDLLRVDL-GIIPER---LRPNNNSFEMQLEMEQQCRGSCFA 127
            :....:....|.|:||:|..:.|||  ||.| ..:..|   ..||..:....:.|          
Mouse   101 IDSFNDSTFMIVYTPITPTTQRIMD--RVSLVSYMTGRKILASPNEENMTELISM---------- 153

  Fly   128 IDFHRVPNRGSD-------RKFRYSLS-SNQMRISPRKRFVNDEEIYHQIDD------DDYIRSG 178
                    |.||       ..:.|:|. ....||...|...:.....|...:      .::.|.|
Mouse   154 --------RFSDVVGVIFTNAYSYNLKFIKGARIPTIKEHQDHTAHCHSYGEIIYCGLSEFWRDG 210

  Fly   179 FLSLQHILDKQYMKYQELGKDFEVVVSSMPNMEVISMDSHRL---TYFG-----TLCSILFNVVL 235
            |::||..::...:         ||..:.....|::|:....:   ::.|     |.|.:.|.::.
Mouse   211 FVALQAAINAAII---------EVTTNHSVMEEMMSLTGKYIKIDSFVGQEGTTTDCFLFFCIIR 266

  Fly   236 LS------SFVVPFVEEKQNGLKEFLNLVTPMSFLN-GLTFFLIRFVCYTLLMIFVLVVAYLYKA 293
            .|      |..|....:|..||...:.|.....:|: ||.:.:|.||...|....|.:|.:::..
Mouse   267 FSPLTYYISAGVTRERKKMKGLMAVMGLRDSAFWLSWGLLYGVIVFVVTLLSTTIVKLVQFVFLT 331

  Fly   294 LGSICFAYVAVLFLLYILSTMSYAYLISICFHSVFYAKI---------GGLAML----IIPYAFS 345
            ...:.|:    ||..|.||.:|.::|:|:.....|...:         |.|...    .:|.:..
Mouse   332 GFMVIFS----LFFFYGLSLISLSFLMSVLLKKSFLTDLVVFLLTVSCGSLGFTALYRYLPVSLE 392

  Fly   346 FVRSWATSLAFVCFSTNTFLEGLDIFQTFSNKRKNREFGAVDVFRV---IKSNSSTM------FS 401
            ::.|..:..||:                         .|.|.:.|:   :.||:..|      ..
Mouse   393 WLLSLLSPFAFM-------------------------LGMVQLLRLDYDVNSNADPMGNPNEVIG 432

  Fly   402 VYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFF----------------LDPKTYMKRQRNE 450
            ...:|.|....|.:|..|...|.|...|.:.|..||                ||.:|..:...:.
Mouse   433 TIFMLFFDGVFYLLLTFYFEKVLPSEYGRRHPPLFFLKSSFWSGQNPANRTALDNETDYEFSDDS 497

  Fly   451 YTTTP---RGTHAIIITELCKKF-QTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIM 511
            :....   .|..||.|..|.|.: |.|||...:.| |.:.:...:||.:|||:||||:|::|::.
Mouse   498 FEPVSMEFHGKEAIRIRNLTKDYIQKSKRTEALKD-LTLDVYKGQITAILGHSGAGKSTLLNVLS 561

  Fly   512 GLVPKDSGKIIVCSER-----DVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARD 571
            ||.....|.:.:.:.:     |:.:...|.|.|||.:|...::|..::|..||:::|....:..:
Mouse   562 GLCVPTKGWVTIHNNKLSEMTDLENISKLTGVCPQCNVQFDFLTVRENLRLFAKIKGIQAHEVDN 626

  Fly   572 WADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILL 636
            .....|.:|.:.:.:|...:|||||.||:|:.||||.|:.:|.:||||::|||..||..:|:.|.
Mouse   627 EVQRVLLELDMKNTQNILVQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHRVWNFLK 691

  Fly   637 NLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVE 701
            ..|.::.||.:|.:|:||::|.|....::.|||:..||.|.||:|.||||.|.|::::....| .
Mouse   692 ERRADRVVLFSTQFMDEADILADRKVFISKGKLKCAGSSLFLKKKWGIGYHLSLQLSETCVHE-R 755

  Fly   702 IMEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFL 766
            |..::...:|.:::.......:...||....|.|.. |||....|.:|||....::.|:|.:|||
Mouse   756 ITSLVKQHIPDSKLSAESEGKLSYILPLERTNKFPD-LYRDLERSPDLGIENYGVSITTLTEVFL 819

  Fly   767 RCAGEQ--DQVD---TPD----GSRND---APLLAHYKRLQDHPPHRGLFQLWMAVFYKKWTFIS 819
            :..|:.  ||.|   |.|    |:|:.   |.:......|......:|...||       |.   
Mouse   820 KLEGKSSIDQSDIGMTEDVQAGGARSPERFAEVEQLVSLLNGRCKMKGGMALW-------WQ--- 874

  Fly   820 NEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLKLSQMGSGVIYVHNPTGHHAHLEQQLR 884
                    .||        |:..:..:.|....:::.:.:..:|.|::::.:     |::.:.:|
Mouse   875 --------QLC--------AVTRLRFLKLKHERKSIVILILVLGIGLLHILS-----ANIYRMVR 918

  Fly   885 QQ--------------------------IELNGITAKT---MHLRGSNDVKNESLDLQRDNLADF 920
            |.                          :.:|...||.   :|            .|::.|:|  
Mouse   919 QSDYCWELAPHMYFLTPGQQPQPPLTNLLIVNKTGAKIDDFIH------------SLEQQNIA-- 969

  Fly   921 LEQVIGIIDMYGGGRGTSDTPTIEIFYSG-------------------NRYHSSVELINLVDSAM 966
            ||     :|.:|...||.|:.     |:|                   .|.:....|:::|.:.:
Mouse   970 LE-----VDAFGTRNGTEDSQ-----YNGAIILSGDEKNYNFTLACNTKRLNCFPVLVDIVSNGL 1024

  Fly   967 LKLGRPESEIDTTYVPIRRFVSDISPSRLEYYAVIVPIGMFFFMF---------YFISLPFREYA 1022
            |.|..|.:.|.|..   ..|..:....:.:|.|       :||::         |.......:|.
Mouse  1025 LGLFAPSAHIQTDR---STFPEENDHRKFDYLA-------YFFLWVLLMACVPPYISMTSIDDYK 1079

  Fly  1023 NGFKQLQT----MSRFTYWFAHFTFDMLILIFVCVALF-SLQSLMMPSELYTTAELKVIVL---- 1078
            |. .|.|.    :|...|||....|::.:...:.:::| :..:...|...:|..:|.:.:|    
Mouse  1080 NR-AQFQLWISGLSPSAYWFGQALFEVPVYCALILSIFIAFYASAPPESKFTVGDLFIQILYVGG 1143

  Fly  1079 --------------------------SIFFYGCSYLPILYALGNNFKSISTISTYLLLMLIVSAI 1117
                                      |:.||..|:..:.:.|.:.|:.||        :.::.|:
Mouse  1144 YAMSVIFMTYVISFIYRKGRKNSGLWSLCFYIVSFFSMCFMLIDYFRDIS--------LFVLIAL 1200

  Fly  1118 APLITSSNAAAMKLHETKIAFLCFLPDFNLNHQFRIINENFITRRHPALIKGLISQDTFFAYATA 1182
            .|..|......:.....:.:.:.|.|:...::.|                        |.|    
Mouse  1201 VPPATLGGCTLLHFENREFSEIIFEPEREYSYLF------------------------FLA---- 1237

  Fly  1183 VGVMVMAFFTIVL---EHKY-LRRRIHDGIWEWAFQRKK-YNSTGTLPSTPISEIDDCAREEKRV 1242
             .::..|.|.::|   |.|: ::....|.::..:.:..: :|:    |..|..|.:|.::|  ||
Mouse  1238 -PLLHFAIFVVILRCMERKFGMKTMRTDPVFRISPRSDRVFNN----PEDPDGEDEDVSQE--RV 1295

  Fly  1243 --------TDLIKDPLNDHSLIVHNLRKRY-----------GDKLAVDGVSFAAAQGECFGLLGV 1288
                    .|..:.|    ::|...|||.|           ..|:|...:||...:||..||||.
Mouse  1296 WTANALTSADFQEKP----AIIASCLRKEYKGKKKCFVLKSKKKIATRNISFCVRKGEVVGLLGH 1356

  Fly  1289 NGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMAL 1353
            |||||:::.:||........|.:.:||:...:..    .:.|||||.:||...:|..:.|...|.
Mouse  1357 NGAGKSTSIKMITGETKPSAGQVLLKGSSTGDTP----GFLGYCPQENALWLNLTVREHLEIFAA 1417

  Fly  1354 LRGLSRRRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEP 1418
            ::|:  |::|...:    ::...:.:.|....|..|:..|.|.||||...::::|.|::||||||
Mouse  1418 IKGM--RKSDANVA----IERLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSVVLLDEP 1476

  Fly  1419 TTGVDPISRRFLWQCIK-DFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRLS 1482
            :||:||..::.:||.|: .|...:|..:||:|.|.|.|.:|:|:|||..|:.:|:.:|..||...
Mouse  1477 STGMDPEGQQQMWQAIQATFSNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKF 1541

  Fly  1483 GFTIKLKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEY 1547
            |....|:||..|.::  |..:...:...||....:|.::..:.|.:..::...|..:.||:... 
Mouse  1542 GKEYLLEMKVKTPSQ--VEPLNTEIMRLFPQAARQERYSSLMVYKLPREDVQPLSQAFFKLETV- 1603

  Fly  1548 LGDRLSALVADYSVNECTLEDIFLKFERE 1576
               :.|..:.:||:::.|||.:||:..:|
Mouse  1604 ---KQSFDLEEYSLSQSTLEQVFLELSKE 1629

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EatoNP_001036360.1 ABC2_membrane_3 <209..347 CDD:289468 35/165 (21%)
CcmA 460..767 CDD:224054 107/312 (34%)
ABC_subfamily_A 461..679 CDD:213230 79/223 (35%)
ABC2_membrane_3 <937..1117 CDD:289468 40/242 (17%)
ABC_subfamily_A 1255..1479 CDD:213230 78/235 (33%)
drrA 1262..1573 CDD:130256 98/322 (30%)
Abca8aXP_006533124.3 rim_protein <258..1630 CDD:130324 364/1533 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838399
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S12404
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.700

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