Protein Alignment Eato and ABCA3

DIOPT Version :9

• Sequence 1: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: NP_001080.2
• Gene: ABCA3 / 21
• HGNCID: 33
• Length: 1704
• Species: Homo sapiens
• Alignment Length: 1764
• Identity: 503/1764 - (28%)
• Similarity: 792/1764 - (44%)
• Gaps: 295/1764 - (16%)

  Fly    14 RKNLLYLQRNLLPLLLICSGFAGVL---------------TAYLHWSVKPVLHQINQFEAKNEMV 63
            ||.|:.:....||||     |:|:|               |.|...|::.:
Human    20 RKVLVTVLELFLPLL-----FSGILIWLRLKIQSENVPNATIYPGQSIQEL-------------- 65

  Fly    64 LRELYF----PGNELDYIYYSPISPNVEDIMDLLRVDLGIIPERLR--PNNNSFEMQLEMEQQCR 122
              .|:|    ||:..:..|....|...:.:.:.:|..| :|..|:|  |:...||..:..: .|.
Human    66 --PLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRAL-VINMRVRGFPSEKDFEDYIRYD-NCS 126

  Fly   123 GSCF-AIDFHRVPNRGSD---------RKFRYSLSSNQMRISPRKRFVNDEEIYHQID------- 170
            .|.. |:.|....|...:         .:|.|: ..|.|.......|:.:.|.:|...
Human   127 SSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYT-RRNYMWTQTGSFFLKETEGWHTTSLFPLFPN 190

  Fly   171 ------------DDDYIRSGFLSLQHILDKQYMKY------QELGKDFEVVVSSMPNMEVISMDS 217
                        :..|||.|||::||.:|:..|:|      ::|.:...|.:...|....|: |.
Human   191 PGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIA-DP 254

  Fly   218 HRLTYFGTLCSILFN--VVLLSSFVV-------PFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIR 273
            .       |.:|.:.  ::||.||..       ..|:||:..|||::.::...|:|:...:||:.
Human   255 F-------LVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLF 312

  Fly   274 FVCYTLLMIFVLV---------VAYLYKALGSICFAYVAVLFLLYILSTMSYAYLISICFHSV-F 328
            |:...:...|:.:         ||.|.::..|:..|::    |.:.:||:|:::::|..|... .
Human   313 FLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFL----LCFAISTISFSFMVSTFFSKANM 373

  Fly   329 YAKIGGLAMLI--IPYAFSFVR-SWATSLAFVC---FSTNTFLEGLDIFQTFSNKRKNREFGAVD 387
            .|..||.....  |||.|...| :|.|....:|   .|......|..:...|..|....::.  |
Human   374 AAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWR--D 436

  Fly   388 VFRVIKSNSSTMF-SVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYM------- 444
            :...:..:....| .|..:|:..|.||.::..|:..||||..|:.:|.:||:.|..:.
Human   437 LLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRAVA 501

  Fly   445 ----------KRQRNEY-TTTPRGTHA-IIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLG 497
                      |..|||| ...|....| |.|..|.|.|:...:|.....:||:.:...:||||||
Human   502 GKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLG 566

  Fly   498 HNGAGKTTMMNMIMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFA 559
            ||||||||.::|:.||.|..||:..:..   .:|:...|..:|.||||.:....:|..:||.|:|
Human   567 HNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYA 631

  Fly   560 QLRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLD 624
            ||:|..|....:...:.|..:||.||.|...:.|||||:|:||:|||:...:|::|||||:||:|
Human   632 QLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMD 696

  Fly   625 INSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLK 689
            ..|||.:||:|...:.::.:::|||:|:||::|||.|.|:|.|:||..||.|.||:|.|.||.:.
Human   697 AISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMT 761

  Fly   690 LEINDFTSREVEIMEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTI 754
            |......:.| :|.:::||.||.|.:.:.....:...||....:.|..:..:||.:.|||||.:.
Human   762 LVKEPHCNPE-DISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASF 825

  Fly   755 SMTDTSLEDVFLRCAGEQDQVDTPDGSRNDAPLL--AHYKRLQD----------HPPHRGL---- 803
            ..:.|::|:||||.....|  .:.|......|.|  .|.:|..|          ..|..|:
Human   826 GASITTMEEVFLRVGKLVD--SSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALI 888

  Fly   804 -----------------FQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGAILVMHAMSLVEN 851
                             .|.| |:|.||..:...||......:.:|..||..|:|.::..|.:.:
Human   889 EEERTAVKLNTGLALHCQQFW-AMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFD 952

  Fly   852 EEALPLKLSQMGSGVIYVHNPTGHHAHLEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQRDN 916
            :..|.|.|.:.|..|:....|.      ..||.||:        :.||:.:...:.:.   .|:.
Human   953 DPMLRLTLGEYGRTVVPFSVPG------TSQLGQQL--------SEHLKDALQAEGQE---PREV 1000

  Fly   917 LADFLEQVIGIIDMYGGG-----------RGTSDTPTIEIFYSGNRYHSSVELINLVDSAMLKL- 969
            |.|..|.:|....:.|||           |...:...:...::...|||....:.:||:.:.||
Human  1001 LGDLEEFLIFRASVEGGGFNERCLVAASFRDVGERTVVNALFNNQAYHSPATALAVVDNLLFKLL 1065

  Fly   970 -GRPESEIDTTYVPIRRFVSDISPSRLEY--------YAVIVPIGMFFFMFYFISLPFREYANGF 1025
             | |.:.|..:..|..|  |.:..::.::        .|:.:...|.|....|..|...|.|...
Human  1066 CG-PHASIVVSNFPQPR--SALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQA 1127

  Fly  1026 KQLQTMSRF---TYWFAHFTFDML------ILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIF 1081
            |.:|.:|..   ::|.:...:|::      :|:.|....|.:::......:..|      :|.:.
Human  1128 KHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADT------LLLLL 1186

  Fly  1082 FYGCSYLPILYALGNNFKSISTISTYLLLMLIVSAIAP--LITSSNAAAMKLHE---TKIAFLCF 1141
            .||.:.:|::|.:...|...:|..|.|.:..|:|.||.  ::|.....|:||.|   |.......
Human  1187 LYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLV 1251

  Fly  1142 LPDFNLNHQFRIINENFITRR---------HPALIKGLISQDTFFAY-ATAVGVMVMA------- 1189
            ||:..|........||:.|||         |......:..|:.|:|: |..||..|.:
Human  1252 LPNHCLGMAVSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCA 1316

  Fly  1190 --FFTIVLEHKYLRRRIHDGIWEWAFQRKK-----YNSTGTLPSTPISEIDDCAREEKRVTDLIK 1247
              ....::|...|:|.  .||. .|.:|::     |.....||     |..|.|.|..|:.....
Human  1317 YLILLFLIETNLLQRL--RGIL-CALRRRRTLTELYTRMPVLP-----EDQDVADERTRILAPSP 1373

  Fly  1248 DPLNDHSLIVHNLRKRYGDK---LAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGG 1309
            |.|....||:..|.|.|..:   ||||.:|.|..:||||||||.||||||:||:|:.....|..|
Human  1374 DSLLHTPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSG 1438

  Fly  1310 TIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKY 1374
            ...:.|..|.....|.|:..|||||:|||...||..:.|...|.|||:..|..   .:|.|:.
Human  1439 DAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHI---GACVENT-- 1498

  Fly  1375 WLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQG 1439
             |..:.|..:....||.||||.||||...:|:||.||::.||||:||:||::||.||..:...:.
Human  1499 -LRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARE 1562

  Fly  1440 KDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEMNVST 1502
            ..:.:::|||||:|||.||.|||||..|:||||.:...||..  ||::::.|::::.:.|. :..
Human  1563 SGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEA-LEE 1626

  Fly  1503 ITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKI---AEEYLGDRLSALVADYSVNEC 1564
            ....:...|||..|.:.|.|.:.|.:..::  :.|:.||.|   |:|..|      |.||||::.
Human  1627 FKAFVDLTFPGSVLEDEHQGMVHYHLPGRD--LSWAKVFGILEKAKEKYG------VDDYSVSQI 1683

  Fly  1565 TLEDIFLKF 1573
            :||.:||.|
Human  1684 SLEQVFLSF 1692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	38/158 (24%)
		CcmA	460..767	CDD:224054	123/310 (40%)
		ABC_subfamily_A	461..679	CDD:213230	94/220 (43%)
		ABC2_membrane_3	<937..1117	CDD:289468	40/198 (20%)
		ABC_subfamily_A	1255..1479	CDD:213230	101/226 (45%)
		drrA	1262..1573	CDD:130256	127/318 (40%)
ABCA3	NP_001080.2	ABC2_membrane_3	<271..469	CDD:289468	46/203 (23%)
		CcmA	530..839	CDD:224054	123/309 (40%)
		ABC_subfamily_A	530..751	CDD:213230	94/220 (43%)
		ABC2_membrane_3	923..1261	CDD:289468	79/363 (22%)
		ABC_subfamily_A	1381..1602	CDD:213230	101/226 (45%)
		drrA	1397..1692	CDD:130256	125/309 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148316
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760