DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and Abcg4

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_620405.3	Gene:	Abcg4 / 192663	MGIID:	1890594	Length:	646	Species:	Mus musculus

Alignment Length:	760	Identity:	155/760 - (20%)
Similarity:	277/760 - (36%)	Gaps:	215/760 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 LGCVFPGPG----------GLKRPMFFFLDPKTYMKRQRNEYTTTPRGTHA-------IIITELC 467
            :||.. |||          |.:.|:.     .|::|:..|..|...|.:|.       |...||.
Mouse     9 VGCGL-GPGAVAMAVTLEDGAEPPVL-----TTHLKKVENHITEAQRFSHLPKRSAVDIEFVELS 67

  Fly   468 KKFQTS----KR--DTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDS---GKIIV 523
            ...:..    ||  .||:. .|:.....:|:..::|.:||||:|.||::.|.  ::|   |:|:|
Mouse    68 YSVREGPCWRKRGYKTLLK-CLSGKFCRRELIGIMGPSGAGKSTFMNILAGY--RESGMKGQILV 129

  Fly   524 CSE-RDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDA-RDWADEKLKKLGLSDKR 586
            ... |::.::|.:..:..|..:.:.::|..:.:...|.|:.:.:.:. ::...|.|..|||....
Mouse   130 NGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCS 194

  Fly   587 NEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYM 651
            :.....||||.::||::.:.:..|..::..|||:||||..|..::..::.:|......::.|.:.
Mouse   195 HTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAHGGRTVICTIHQ 259

  Fly   652 EEAEV--LGDTICILANGKLQSIGSPLEL-KRKSGIGYRLKLEIN--DFTSREVEIMEIIHHFVP 711
            ..|::  :.|.:.||:.|:....|....| ....|:|.......|  ||      |:|:
Mouse   260 PSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADF------IIEV------ 312

  Fly   712 TARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESK-ELGIHTISMTDTSLEDVFLRCAGEQDQV 775
            .:.....:||.::    .|.:|....|..:..:..| ||..|..:            |..|.|
Mouse   313 ASGEYGDLNPMLF----RAVQNGLCTMAEKKSSPGKNELPAHCPT------------CPPELD-- 359

  Fly   776 DTPDGSRNDAPLLAHYKRLQDHPPHRGLFQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGAI 840
                      |:.:|                         ||.::    ||...||.|...|.:|
Mouse   360 ----------PIESH-------------------------TFATS----TLTQFCILFRRTFLSI 385

  Fly   841 L----VMHA--MSLVENEEALPLKLSQMGSGVIYVHNPTGH------------------HAHLEQ 881
            |    :.|.  ||.|.....:.|....:|.....|.|.||.                  ...||.
Mouse   386 LRDTVLTHLRFMSHVLIGVLIGLLYLHIGDDASKVFNNTGFLFFSMLFLMFAALMPTVLTFPLEM 450

  Fly   882 QLRQQIELN-GITAKTMHLRGSNDVKNESLDLQRDNLADFLEQVI------GIIDMYGGGRGTSD 939
            .:..:..|| ..|.|..:|              ...:||...||:      .|:....|  ..::
Mouse   451 AVFMREHLNYWYTLKAYYL--------------AKTMADVPFQVVCPVVYCSIVYWMTG--QPAE 499

  Fly   940 TPTIEIFYSGNRYHSSVELINLVDSAMLKLGRPESEIDTTYVPIRRFVSDISPSRLEYYAVIVPI 1004
            |....:|.:     .::....:..|..|.:|..     :|.:.:..||..::         .:|:
Mouse   500 TSRFLLFSA-----LAIATALVAQSLGLLIGAA-----STSLQVATFVGPVT---------AIPV 545

  Fly  1005 GMFFFMFYFISLPFREYANGFKQLQTMSRFTYW--FAHFTFDMLILIFVCVALFSLQSL------ 1061
              ..|..:|:|         ||.:.|..:::.:  :..:.|:.|||....:....|..|
Mouse   546 --LLFSGFFVS---------FKTIPTYLQWSSYLSYVRYGFEGLILTIYGMERGHLTCLDEQCPF 599

  Fly  1062 -----------MMPSELYTTAELKVIVLSIFFYG---CSYLPILY 1092
                       :..::||    :..:||.|||..   .:||.:.|
Mouse   600 RDPQIILRELDVEEAKLY----MDFLVLGIFFLALRLLAYLVLRY 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468
		CcmA	460..767	CDD:224054	73/330 (22%)
		ABC_subfamily_A	461..679	CDD:213230	57/231 (25%)
		ABC2_membrane_3	<937..1117	CDD:289468	31/178 (17%)
		ABC_subfamily_A	1255..1479	CDD:213230
		drrA	1262..1573	CDD:130256
Abcg4	NP_620405.3	3a01204	44..646	CDD:273361	145/719 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000