Protein Alignment Eato and abt-1

DIOPT Version :9

• Sequence 1: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: NP_001293854.1
• Gene: abt-1 / 182849
• WormBaseID: WBGene00000019
• Length: 1558
• Species: Caenorhabditis elegans
• Alignment Length: 1770
• Identity: 326/1770 - (18%)
• Similarity: 639/1770 - (36%)
• Gaps: 449/1770 - (25%)

  Fly    14 RKNLLYLQRN----LLPLLLICSGFAGVLTAYLHWSVKPV---------LHQINQFE-AKNEMVL 64
            :|:|.|.:.|    :|..:::...|..|     .|...|.         .|..:.|. :|.:.|.
 Worm    20 QKDLNYFRSNHPFFILIFIVLSLAFYNV-----WWHNSPTRDQSGDASKFHLFDNFRLSKQKFVK 79

  Fly    65 RELYFPGNELDYIYYSPIS---------PNVEDIMDLLR---------VDLGIIPERLRPNNNSF 111
            ..:..|...:||.:.:.|.         |::|....|.:         ||..::.:.|.......
 Worm    80 MIVCIPETVVDYRFSTVIDAIHLTHLDYPHLEFTKKLEKAKNKLEDGEVDFLVLFKTLIETGKKI 144

  Fly   112 EMQLEMEQQCRGS-CFAIDFHRVPNRGSD-------RKFRYSL--SSNQMRISPRKRFVNDEEIY 166
            |.::..||..... |...|.||....|:.       .:|.|.|  |....:.||..:..|   :|
 Worm   145 EYKIISEQGVFDKHCIQCDVHRKKTWGNAVEAQVVVNRFLYWLVKSRGFNKRSPHWQLSN---VY 206

  Fly   167 --HQIDDDDYI-RSGFLSLQHIL--------------DKQYMKYQELGKDFEVVVSSMPNMEVIS 214
              |..:|..:: |...|.|..||              |:.               |...|| .:|
 Worm   207 VKHSGNDPMFLKRQSDLFLLWILLLPICSRLIDLWNNDRS---------------SGYYNM-FLS 255

  Fly   215 MDSHRLTYFGTLCSILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYTL 279
            :.:.|..||.......:.:.|:.|.:|..|..          ||.|..|            |.|.
 Worm   256 LHARRFHYFIAKFVFWYGIALIISLIVFIVNV----------LVVPAVF------------CSTY 298

  Fly   280 LMIFVLVVAYLYKALGSICFAYVAVLFLLYILSTMSYAYLISICFHSVFYAKI-GGLAMLIIPYA 343
            |. ||            :|:|...:.|.:::.:|..         .|..:||| |.|:|:...:.
 Worm   299 LQ-FV------------VCYAACIISFAIFLATTFP---------GSPLFAKIVGFLSMVAGEFG 341

  Fly   344 FSFVRSWATSLAFVCFSTNTFLEGLDIFQTFSNKRKNREFGA--VDVFRVIKSNSSTMFSVYVVL 406
            |                 .|...|:..||.........||..  :|....:....:.:..:.|.:
 Worm   342 F-----------------GTVYHGIGFFQLCVRHFGKSEFDGPWIDAVCTLCMTGNCVLLITVSI 389

  Fly   407 VFQSFLYAMLYNYLGCVFPGPGGLKRPMF-----------FFLDPKTYMKRQRNEYTT------- 453
            .|.::........|...||    |::..:           ||:.....:|..|:|.|.
 Worm   390 YFDTYFCLFTMEPLAFYFP----LEKDYWMPEARSPQLDTFFVKQIILLKPGRSEITVKKAHDEI 450

  Fly   454 --------------TP--RGTHAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAG 502
                          ||  :|...:::..:||:.:...|...:|    :|::..|:..|.||:|.|
 Worm   451 LPAKTSTGSKYIPPTPIVKGVPLVVLYGICKRIENHWRVKQVS----LTVHLGEVVTLYGHHGCG 511

  Fly   503 KTTMMNMIMGLVPKDSGKI---------IVCSERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFF 558
            ...::::|.|.:..:.|::         ::....||.:              ::|:...|:|...
 Worm   512 SGEILSIIAGQMKPEYGEVMMEQSQRPLMISKTTDVPN--------------VNYLNVIQYLRLI 562

  Fly   559 AQLRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGL 623
            :::||...|.:.  .||.|::|.|...:|.....||...|.||.:.....|...:|::|.|:
 Worm   563 SKMRGVSASTSH--IDEMLEELDLIKVKNRSLDLLSTTQKERLRIAAVFVGQPDLVLIDFPT--- 622

  Fly   624 DINSRRELWDIL----LNLRKEK-AVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSG 683
             :....| |..:    :..|||| :::|:::..||.|.:.|.:.:::.|.:...||....|....
 Worm   623 -MECLPE-WKFMVFRFIEKRKEKRSIIVSSYDPEETEAISDKVVLMSEGYVVLNGSCEAFKHSIN 685

  Fly   684 IGYRLKLEIND-FTSREVE-IMEII----HHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRL 742
            ..:.:::..|: ||..::: :|:.:    :.....||.....|..:.:.||..|:.....:|..|
 Worm   686 SVFEIRIWPNNRFTDEQIKGMMKTLTLGDNQMKNDARFFETPNGKIRVTLPILYRRSIPLILREL 750

  Fly   743 ETESKELGIHTISMTDTSLEDVFLRCAGEQDQVDTPDGSRNDAPLLAHYKRLQDH-----PPHRG 802
            :...::..|....:...::.|::.....|..|:|.          |:.:.:|:||     |.::.
 Worm   751 DAVHEKFRIEFYELGKPNIHDIYANACYEHQQLDP----------LSTFDQLRDHYTKQQPLNKK 805

  Fly   803 LFQLWMAVFYKKWTFISNEWLYTLIMLCIPFVCVFGAILVMHAMSLV-------ENEEALPLKLS 860
            .:      |:|....|..:..:     .|....|.|..|::..:.|:       ::.:...:.|:
 Worm   806 TY------FFKNMIHIFKDGRF-----LIETAAVVGLFLILTVIILLSYHSVESDSHQTREISLT 859

  Fly   861 QMGSGV-IYVHNPTGHHAHLEQQLRQQIELNGIT----AKTMHLRGSNDV---------KNESLD 911
            ...|.: ||.           .:..::: :.|:|    ::.:.|..:..|         ..|.:.
 Worm   860 SYESPITIYC-----------DECEKEV-IEGVTFEKKSRVLQLENNQAVLYWKDTAKADKELIT 912

  Fly   912 LQR-DNLADFLEQVIGIIDMYGGGRGTSDTPTIEIFYSGNRYHSSVELINLVDSAMLKLGRPESE 975
            :.| |.|...:.|...:..|.  .:.|...|.|::|.......::.|:               |.
 Worm   913 VSRGDALFTMIVQNFAVSQMI--SKITGKHPQIKLFLESENVRTATEI---------------SG 960

  Fly   976 IDTTYVPIRRFVSDISPSR-----LEYYAVIVPIGMF-FFMFYF-ISLPFREYANGF---KQLQT 1030
            ..|.:       :|||.|:     .|.|:::....:| .|::.| :.||.|..:...   ..:..
 Worm   961 FSTVF-------NDISSSKAAMILTESYSLMYITAVFQMFVYTFSVVLPLRLVSTNMGPQSMILP 1018

  Fly  1031 MSRFTYWFAHFTFDMLILIFVCVAL-FSLQSLMMPSELYTTAELKVIVLSIFFYG-CSYLPILYA 1093
            ..|:.|:...:.|.:::.:.:.:.| |::.|:...:...|:..|:  .||.:|.. .|.||::|.
 Worm  1019 WPRYVYFGFIYVFQLVVFLVIAIILGFAVLSMGFFATNTTSCYLR--FLSAWFLSYASTLPLIYF 1081

  Fly  1094 LGNNFKSISTISTYLLLMLIVSAIAP-LITSSNAAAMKLHETKIAFL---CFL-PDFNLNHQFRI 1153
            |..|.::..::...:|.:..:|...| |:.|.:|......::.|.|:   |.| |..:|......
 Worm  1082 LVFNIQNTKSVIPIILAISSLSVTFPNLVASFSAENQVSLQSLIQFVSWSCMLNPPSSLQVLAAF 1146

  Fly  1154 INENFITRRHPALIKGLISQDTFFAYATAVGVMVMAFFTIVLE--HKYLRRRIHDGIWEW----- 1211
            :|......::...|..||      .:..|...:::.|..::.:  ..|:::       .|
 Worm  1147 LNAGESLEKNSGTITSLI------LFCGAQFWIIVIFVLVIFQPGFSYIQQ-------YWFKSST 1198

  Fly  1212 ----AFQR-------KKYNSTGTLPSTPISEIDDCAREEKRV-----------TDLIKDPLNDHS 1254
                :|:|       .:..::....:.|:..::|.  ::|..           |:.::.|.:|:.
 Worm  1199 VLYSSFERGTTLKPGARIKNSYIFVTNPLGTMEDA--QDKGASGNIPNRPAAGTEPVQKPTSDYI 1261

  Fly  1255 LIVHNLRKRYGDKLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAAN----LPLD-------G 1308
            .         |..:::|.:|:.....|       |...|.:|  |.:.|    :|:|       |
 Worm  1262 A---------GSSMSIDDMSYITNYEE-------NLVEKMAT--MTSWNDKQEVPVDNSATFLMG 1308

  Fly  1309 GTIRIKGADIRE-HELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHV 1372
            ...::|.|.:.. .::...|:..:.|..:.::...|..:.|...|...|.  ..||      :|:
 Worm  1309 DQTKLKSALLTTIAKINKNEHIAFVPIVENISTIYTPFELLENAAYCNGF--EITD------DHI 1365

  Fly  1373 KYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDF 1437
            .|.|:...|.::...|::......:|.|:....::..|.:|::|:....:.......:|......
 Worm  1366 SYLLDAFDLKEHANTQIKLLPCIDRRILMLLAKLVIKPNIVIIDQLEMFLPHSKMMTVWSFCARL 1430

  Fly  1438 QGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRLSGFTIKLK---MKADTETEMN 1499
            :.....::.|||.....|......|.|..|:|        ::.|...:||.|   ::...:|..:
 Worm  1431 RKNGLGIIYTSHHSGFAEHTATCCAHMYKGQF--------VRNLLPTSIKAKCTVLEVVPKTASD 1487

  Fly  1500 VSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVL------WSSVFKIAEEYLGDRLSALVAD 1558
            ...:...|:.     |:.||     ....||..::.|      ..::.||.|  |...||..:..
 Worm  1488 PKVLLHMLQK-----EMEES-----VKLPSTSRNITLAMYKDGVETIEKILE--LLRMLSPQIKR 1540

  Fly  1559 YSV--NECTLEDIFL 1571
            ||:  ..|   |.||
 Worm  1541 YSLRSGNC---DEFL 1552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	31/138 (22%)
		CcmA	460..767	CDD:224054	66/326 (20%)
		ABC_subfamily_A	461..679	CDD:213230	51/231 (22%)
		ABC2_membrane_3	<937..1117	CDD:289468	38/191 (20%)
		ABC_subfamily_A	1255..1479	CDD:213230	41/235 (17%)
		drrA	1262..1573	CDD:130256	65/333 (20%)
abt-1	NP_001293854.1	rim_protein	<256..>676	CDD:130324	99/509 (19%)
		P-loop_NTPase	474..677	CDD:393306	50/227 (22%)
		ABC2_membrane_3	<917..1176	CDD:378925	57/290 (20%)
		CcmA	<1328..1491	CDD:224054	32/178 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12404
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.870