DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eato and Abca1

DIOPT Version :10

Sequence 1:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster
Sequence 2:XP_006537617.1 Gene:Abca1 / 11303 MGIID:99607 Length:2263 Species:Mus musculus


Alignment Length:1882 Identity:477/1882 - (25%)
Similarity:803/1882 - (42%) Gaps:452/1882 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 LHWSVKPVLHQINQFEAKNEMVLRELYFPGNELDYIYYSPISPNVEDIMDLLRV-------DLGI 99
            |.|:.:.::    .|.|||.   .::..|...: |.:....:...:.|..:.|.       .|..
Mouse   456 LDWTAQDIM----AFLAKNP---EDVQSPNGSV-YTWREAFNETNQAIQTISRFMECVNLNKLEP 512

  Fly   100 IPERLRPNNNSFEMQLEMEQQCRGSCF---AIDFHRVPNRGSDRKFRYSLSSNQMRISPRKRFVN 161
            ||..:|..|.|.|: |:..:...|..|   ..|...:|:.     .:|.:   :|.|...:|...
Mouse   513 IPTEVRLINKSMEL-LDERKFWAGIVFTGITPDSVELPHH-----VKYKI---RMDIDNVERTNK 568

  Fly   162 DEEIY-------HQIDDDDYIRSGFLSLQHILDKQYMKY---QELGKDFEVVVSSMP-----NME 211
            .::.|       ...:|..|:..||..||.::::..::.   .|  |...|.|..||     :..
Mouse   569 IKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGSE--KKTGVYVQQMPYPCYVDDI 631

  Fly   212 VISMDSHRLTYFGTLCSILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFF------ 270
            .:.:.|..:..|.||..|....|::.|.|.    ||:..|||.:.:   |...||:.:|      
Mouse   632 FLRVMSRSMPLFMTLAWIYSVAVIIKSIVY----EKEARLKETMRI---MGLDNGILWFSWFVSS 689

  Fly   271 LIRFVCYTLLMIFVLVVAYLYK-ALGSICFAYVAVLFLLYILSTMSYAYLISICF-HSVFYAKIG 333
            ||..:....|::.:|.:..|.. :..|:.|.:::|..::.||.    .:|||..| .:...|..|
Mouse   690 LIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAMVTILQ----CFLISTLFSRANLAAACG 750

  Fly   334 GLA--MLIIPYAFSFVRSWATSLAFVCFSTNTFLE---------GLDIFQTFSNKRKNREFGAVD 387
            |:.  .|.:||....  :|..   :|.||...|..         |.:.|..|..:....::.  :
Mouse   751 GIIYFTLYLPYVLCV--AWQD---YVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWD--N 808

  Fly   388 VFR-VIKSNSSTMFSVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFF----------FLDPK 441
            :|. .::.:...:.:...:::|.:|||.::..|:..||||..|:.||.:|          .:|.|
Mouse   809 LFESPVEEDGFNLTTAVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEK 873

  Fly   442 TY---MKRQRNEYTTTPRGTH---AIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNG 500
            ::   .::..:|.......||   .:.|..|.|.::...:  :..|.|.:.....:||..|||||
Mouse   874 SHPGSSQKGVSEICMEEEPTHLRLGVSIQNLVKVYRDGMK--VAVDGLALNFYEGQITSFLGHNG 936

  Fly   501 AGKTTMMNMIMGLVPKDSGKIIVCSE---RDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLR 562
            |||||.|:::.||.|..||...:..:   .:::|.|..:|.||||:|....:|..:|:.|:|:|:
Mouse   937 AGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLK 1001

  Fly   563 GACRSDARDWADEKLKKLGL-SDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDIN 626
            |......:...::....:|| ..|.......|||||:|:||:.:|..|.:|:||||||::|:|..
Mouse  1002 GLSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPY 1066

  Fly   627 SRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLE 691
            |||.:|::||..|:.:.::::||:|:||::|||.|.|:::|||..:||.|.||.:.|.||.|.|.
Mouse  1067 SRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLV 1131

  Fly   692 INDFTSR--------------------------------EVE-----------IMEIIHHFVPTA 713
            ..|..|.                                ||:           |..:|...|..|
Mouse  1132 KKDVESSLSSCRNSSSTVSCLKKVVPGLPAAGQSGGRGGEVQRLVALTQDVSAISNLIRKHVSEA 1196

  Fly   714 RVLNVVNPTVYICLPY--AYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQVD 776
            |::..:...:...|||  |.:..|.::.:.::....:|||.:..:::|:||::||:.| |:..||
Mouse  1197 RLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVA-EESGVD 1260

  Fly   777 --TPDGSRNDAPLLAHYKRLQD-----HP--------PH-------------------RGLFQL- 806
              |.||:   .|...:.:...|     ||        |:                   :|.:|| 
Mouse  1261 AETSDGT---LPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDIDPESRETDLLSGMDGKGSYQLK 1322

  Fly   807 -W-------MAVFYKKWTFI--SNEWLYTLIMLCIPFVCV----------FGAILVMHAMSLVEN 851
             |       :|:.:|:....  |.:..:..|:|...|||:          ||....:.....:.|
Mouse  1323 GWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYN 1387

  Fly   852 E---------------------------------EALPL-------------------------- 857
            |                                 |..|:                          
Mouse  1388 EQYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPDTPCLAGEEDWTISPVPQSIVDLFQ 1452

  Fly   858 ------------------KLSQM------GSGVI-----------YVHNPTGHHAH--------- 878
                              |:.:|      |:|.:           .:.|.||.:..         
Mouse  1453 NGNWTMKNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQ 1517

  Fly   879 -LEQQLRQQIELN---------GITAKTMHLRGSNDVKN------ESLDLQRDNLAD-FLEQVIG 926
             :.:.|:.:|.:|         |: :.:..|..|::|.:      :.|.|.:|:.|| ||..:  
Mouse  1518 IIAKSLKNKIWVNEFRYGGFSLGV-SNSQALPPSHEVNDAIKQMKKLLKLTKDSSADRFLSSL-- 1579

  Fly   927 IIDMYGGGR---GTSDTPTIEIFYSGNRYHSSVELINLVDSAMLKLGRPESEIDTTY-VPIRRFV 987
                   ||   |......::::::...:|:....:|::::|:|:....:.|..:.| :......
Mouse  1580 -------GRFMAGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFNHP 1637

  Fly   988 SDISPSRLEYYA-------VIVPIGMFFFMFY----FISLPFREYANGFKQLQTMS---RFTYWF 1038
            .:::..:|...|       |:|.|.:.|.|.:    |:....:|..:..|.||.:|   ...||.
Mouse  1638 LNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWL 1702

  Fly  1039 AHFTFDM---------LILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYAL 1094
            ::|.:||         :|:||:|   |..:|.:      ::..|.|:.|.:..||.|..|::|..
Mouse  1703 SNFVWDMCNYVVPATLVIIIFIC---FQQKSYV------SSTNLPVLALLLLLYGWSITPLMYPA 1758

  Fly  1095 GNNFKSISTISTYLLLM----------LIVSAIAPLITSSNAAAMKLHE----TKIAFLCFLPDF 1145
            ...||..||  .|::|.          .:.:.:..|.|::     ||::    .|..||.| |.|
Mouse  1759 SFVFKIPST--AYVVLTSVNLFIGINGSVATFVLELFTNN-----KLNDINDILKSVFLIF-PHF 1815

  Fly  1146 NL---------NHQFRIINENFITRRHPA-LIKGLISQDTFFAYATAVGVMVMAFFTIVLEHKYL 1200
            .|         |.......|.|...|..: |...|:.::.|   |.||..:|....|::::::: 
Mouse  1816 CLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLF---AMAVEGVVFFLITVLIQYRF- 1876

  Fly  1201 RRRIHDGIWEWAFQRKKYNSTGTLPSTPISEID-DCAREEKRVTDLIKDPLNDHSLIVHNLRKRY 1264
                        |.|.: .....||  |:::.| |..||.:|:.|  ....|| .|.:..|.|.|
Mouse  1877 ------------FIRPR-PVKAKLP--PLNDEDEDVRRERQRILD--GGGQND-ILEIKELTKIY 1923

  Fly  1265 GDKL--AVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYRE 1327
            ..|.  |||.:......||||||||||||||::||:|:..:.|:..|...:....|..:..:..:
Mouse  1924 RRKRKPAVDRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLNKNSILSNIHEVHQ 1988

  Fly  1328 YFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYW-LEKMHLTKYQKVQVRH 1391
            ..|||||:||:.:.:|..:.:.:.|||||:..:...       .|..| :.|:.|.||.:....:
Mouse  1989 NMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVG-------KVGEWAIRKLGLVKYGEKYASN 2046

  Fly  1392 YSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEE 1456
            ||||.||||..|||:||.|.:|.|||||||:||.:|||||.|......:.|:||||||||:|||.
Mouse  2047 YSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEA 2111

  Fly  1457 LCNRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGTLKSEFPGLELRES 1519
            ||.|:|||.:|:|:||.::..||..  .|:||.:::.........|....|.   .|||..|:|.
Mouse  2112 LCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFGL---AFPGSVLKEK 2173

  Fly  1520 HAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQS 1581
            |...|.|.:.:..|.:  :.:|.|..:   .:....:.||||::.||:.:|:.|   ||.||
Mouse  2174 HRNMLQYQLPSSLSSL--ARIFSILSQ---SKKRLHIEDYSVSQTTLDQVFVNF---AKDQS 2227

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EatoNP_001036360.1 rim_protein <169..1591 CDD:130324 450/1738 (26%)
Abca1XP_006537617.1 rim_protein 6..2238 CDD:130324 477/1882 (25%)

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