DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and ABCA8

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001275914.1	Gene:	ABCA8 / 10351	HGNCID:	38	Length:	1621	Species:	Homo sapiens

Alignment Length:	1730	Identity:	422/1730 - (24%)
Similarity:	729/1730 - (42%)	Gaps:	329/1730 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVLRELYFPGNELDYIYYSPISPNVEDIMDLL 93
            |:|..|      ...|.:|    :.:..|..|.::|         |..:|..|.|..|.|...||
Human    15 LLCKNF------LKKWRMK----RESLMEWLNSLLL---------LLCLYIYPHSHQVNDFSSLL 60

  Fly    94 RVDLGIIPERLRPNNNS-----FEMQLEMEQQCRGSCFAIDFHR------VPNRGSDRKFRYSLS 147
            .:|||    |:...|.|     :.......||......:..|..      :|:..|.::|..:..
Human    61 TMDLG----RVDTFNESRFSVVYTPVTNTTQQIMNKVASTPFLAGKEVLGLPDEESIKEFTANYP 121

  Fly   148 SNQMRIS-----------------PRKR---------FVNDEEIYHQIDDDDYIRSGFLSLQHIL 186
            ...:|::                 |.|:         :..:|::|.::  ..:.:.||::||..:
Human   122 EEIVRVTFTNTYSYHLKFLLGHGMPAKKEHKDHTAHCYETNEDVYCEV--SVFWKEGFVALQAAI 184

  Fly   187 DKQYMKYQELGKDFEVVVSSM----PNMEVISMDSHRLTYFGTLCSI-LFN-VVLLSSFV----V 241
            :...:   |:..:..|:...|    .||::.|.    :...|.:..: ||: ::..|||:    |
Human   185 NAAII---EITTNHSVMEELMSVTGKNMKMHSF----IGQSGVITDLYLFSCIISFSSFIYYASV 242

  Fly   242 PFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYT-LLMIFVLVVAYLYKALGSIC---FAYV 302
            ....|:    |....|:|.|. |....|:|...:.|. .:.|..|.:|.:.::...|.   |..|
Human   243 NVTRER----KRMKALMTMMG-LRDSAFWLSWGLLYAGFIFIMALFLALVIRSTQFIILSGFMVV 302

  Fly   303 AVLFLLYILSTMSYAYLISICFHSVFYAKIGGLAMLIIPYAF------SFVRSWATSLAFV--CF 359
            ..|||||.||.::.|:|:||.....|   :.||.:.::...:      |..|....||.::  ..
Human   303 FSLFLLYGLSLVALAFLMSILVKKSF---LTGLVVFLLTVFWGCLGFTSLYRHLPASLEWILSLL 364

  Fly   360 STNTFLEG------LDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYVVLVFQSFLYAMLYN 418
            |...|:.|      || :...||           .|......|:.:.:...:|.|.:.||..|..
Human   365 SPFAFMLGMAQLLHLD-YDLNSN-----------AFPHPSDGSNLIVATNFMLAFDTCLYLALAI 417

  Fly   419 YLGCVFPGPGGLKRPMFFFLDPKTYMKRQRNEYTTTP--------------------RGTHAIII 463
            |...:.|...|.:||..|||....:.:.|:.::....                    :|..||.|
Human   418 YFEKILPNEYGHRRPPLFFLKSSFWSQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAIRI 482

  Fly   464 TELCKKFQTSKRDTLIS-DNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIVCSER 527
            ..:.|::: .|.|.:.: .:|...|...:||.:|||:||||:|::|::.||.....|.:.:.:.:
Human   483 RNVTKEYK-GKPDKIEALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNK 546

  Fly   528 -----DVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGLSDKRN 587
                 |:.:...|.|.|||.:|...::|..::|..||:::|....:........|.:|.:.:.::
Human   547 LSEMADLENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIQRVLLELEMKNIQD 611

  Fly   588 EFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYME 652
            ...:|||||.||:|:.||||.|:.:|.:||||::|||..||.::|::|...:.::.:|.:|.:|:
Human   612 VLAQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHQVWNLLKERKTDRVILFSTQFMD 676

  Fly   653 EAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEIMEIIHHFVPTARVLN 717
            ||::|.|....|:.|||:..||.|.||:|.||||.|.|::|:....| .|..::...:|.|::..
Human   677 EADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEICVEE-NITSLVKQHIPDAKLSA 740

  Fly   718 VVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAG-----EQD---- 773
            .....:...||....|.|.: ||:......:|||....::.|:|.:|||:..|     |.|
Human   741 KSEGKLIYTLPLERTNKFPE-LYKDLDSYPDLGIENYGVSMTTLNEVFLKLEGKSTINESDIAIL 804

  Fly   774 ---QVDTPDGSRNDAPLLAHYKRLQDHPPHRGLFQLW----MAVFYKKWTFISNEWLYTLIMLCI 831
               |.:..|.:.....:......|.......|...||    .|:...:...:.:|....|.:|.|
Human   805 GEVQAEKADDTERLVEMEQVLSSLNKMRKTIGGVALWRQQICAIARVRLLKLKHERKALLALLLI 869

  Fly   832 PFVCVFGAILVMHAM-SLVENEEALPLKLSQMGSGVIYVHNPTGHHAHLEQQLRQQIELNGITAK 895
             .:..|..:||.:.| .:.:|.....|      |..:|...| |...|  ..|.|.:.:|    |
Human   870 -LMAGFCPLLVEYTMVKIYQNSYTWEL------SPHLYFLAP-GQQPH--DPLTQLLIIN----K 920

  Fly   896 TMHLRGSNDVKNESLDLQRDNLADFLEQV----IGI-IDMYGGGRGTSD---TPTIEIFYSGNRY 952
            |          ..|:|       ||::.|    |.: :|.:|...||.|   ...|.:..:...|
Human   921 T----------GASID-------DFIQSVEHQNIALEVDAFGTRNGTDDPSYNGAITVCCNEKNY 968

  Fly   953 HSSVE-----------LINLVDSAMLKLGRPESEIDTTYVPIRRFVSDISPSRLEYYAVIVPIG- 1005
            ..|:.           |:::|.:.:|.:.:|...|.|..   ..|:.:...:         |||
Human   969 SFSLACNAKRLNCFPVLMDIVSNGLLGMVKPSVHIRTER---STFLENGQDN---------PIGF 1021

  Fly  1006 MFFFMFYFI---SLP----------FREYANGFKQLQTMSRFTYWFAHFTFD--MLILIFVCVAL 1055
            :.:.||:.:   |.|          ::..|....::..:|...|||.....|  :..|:||.:.|
Human  1022 LAYIMFWLVLTSSCPPYIAMSSIDDYKNRARSQLRISGLSPSAYWFGQALVDVSLYFLVFVFIYL 1086

  Fly  1056 FSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLLLML-------- 1112
            .|..|        ...::.:.::.|....|       |:|.:|..|  ..||::..:
Human  1087 MSYIS--------NFEDMLLTIIHIIQIPC-------AVGYSFSLI--FMTYVISFIFRKGRKNS 1134

  Fly  1113 -IVSAIAPLITSSNAA--AMKLHETKIAFL--CFLPDFNLNHQFRIINENFITRRHPALIKGLIS 1172
             |.|....::|..:.|  |..:.|:.|.|:  ..:|...:      |...|::..  .|...|.|
Human  1135 GIWSFCFYVVTVFSVAGFAFSIFESDIPFIFTFLIPPATM------IGCLFLSSH--LLFSSLFS 1191

  Fly  1173 QDTFFAYATAVGVMVMAFFTIVLEHKYLRRRIHDGIWEWAFQRK------------KYNSTGTLP 1225
            ::........|.::....|.|.|   :..|.:     ||.|.:|            :.:.....|
Human  1192 EERMDVQPFLVFLIPFLHFIIFL---FTLRCL-----EWKFGKKSMRKDPFFRISPRSSDVCQNP 1248

  Fly  1226 STPISEIDDCAREEKRVTDLIKDPLNDHS--LIVHNLRKRYG-----------DKLAVDGVSFAA 1277
            ..|..|.:|...|..|..:.:.....|..  :|...|||.|.           :|:|...|||..
Human  1249 EEPEGEDEDVQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCV 1313

  Fly  1278 AQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFM 1342
            .:||..||||.|||||:::.::|..:.....|.:.:||:...:    ..|:.|||||.:||...:
Human  1314 RKGEVLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKGSGGGD----ALEFLGYCPQENALWPNL 1374

  Fly  1343 TAEQCLYYMALLRGLSRRRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMI 1407
            |..|.|...|.::||  |:.|...:    :...::.:.|....|..|:..|.|.||||...::::
Human  1375 TVRQHLEVYAAVKGL--RKGDAEVA----ITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSIL 1433

  Fly  1408 GAPALVLLDEPTTGVDPISRRFLWQCIK-DFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKC 1471
            |.|::||||||:||:||..::.:||.|: .|:..:|..:||:|.|.|.|.:|:|:|||..|:.:|
Human  1434 GNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRC 1498

  Fly  1472 LNNICALKRLSGFTIKLKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVL 1536
            :.:|..||...|....|:||.....:  |..:...:...||....:|.::..:.|.:..::...|
Human  1499 IGSIQHLKSKFGKDYLLEMKVKNLAQ--VEPLHAEILRLFPQAARQERYSSLMVYKLPVEDVQPL 1561

  Fly  1537 WSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFERE 1576
            ..:.||:.:.    :.|..:.:||:::.|||.:||:..:|
Human  1562 AQAFFKLEKV----KQSFDLEEYSLSQSTLEQVFLELSKE 1597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	40/153 (26%)
		CcmA	460..767	CDD:224054	102/312 (33%)
		ABC_subfamily_A	461..679	CDD:213230	74/223 (33%)
		ABC2_membrane_3	<937..1117	CDD:289468	41/218 (19%)
		ABC_subfamily_A	1255..1479	CDD:213230	81/235 (34%)
		drrA	1262..1573	CDD:130256	100/322 (31%)
ABCA8	NP_001275914.1	rim_protein	<235..>790	CDD:130324	163/577 (28%)
		ABC_subfamily_A	480..703	CDD:213230	74/223 (33%)
		rim_protein	<1033..1598	CDD:130324	156/614 (25%)
		ABC_subfamily_A	1285..1506	CDD:213230	80/230 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650