DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Eato and ABCA9

DIOPT Version :9

Sequence 1:NP_001036360.1 Gene:Eato / 34783 FlyBaseID:FBgn0028539 Length:1597 Species:Drosophila melanogaster
Sequence 2:XP_024306297.1 Gene:ABCA9 / 10350 HGNCID:39 Length:1634 Species:Homo sapiens


Alignment Length:1729 Identity:424/1729 - (24%)
Similarity:741/1729 - (42%) Gaps:303/1729 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 FVFLRKNLL----YLQRNLLPLLLICSGFAGVLTAYLHWSVKPVLHQINQFEAKNEMVL-RELYF 69
            :..|.||.|    ..::.||..|.   .|..||..||.:|   .|||::.....:.|.| |...|
Human    21 WALLCKNCLKKWRMKRQTLLEWLF---SFLLVLFLYLFFS---NLHQVHDTPQMSSMDLGRVDSF 79

  Fly    70 PGNELDY-IYYSPISPNVEDIMDLL--------RVDLGIIPERLRPNNNSFEMQLEMEQQCRGSC 125
              |:.:| |.::|.|...::||:.:        |..:|      .|:..|.: :|::.       
Human    80 --NDTNYVIAFAPESKTTQEIMNKVASAPFLKGRTIMG------WPDEKSMD-ELDLN------- 128

  Fly   126 FAIDFHRVPNRGSDRKFRYSLSSNQMRISPRKRFVNDEEIYHQ-------IDDDDYIRSGFLSLQ 183
            ::||..||....:   |.|.|..:.....|..:...|...:.|       .:..::...||::.|
Human   129 YSIDAVRVIFTDT---FSYHLKFSWGHRIPMMKEHRDHSAHCQAVNEKMKCEGSEFWEKGFVAFQ 190

  Fly   184 HILDKQYMKYQELGKDFEVVVS----SMPNMEVISMDSHRLTYFGTLCSILFNVVLLSSFV---- 240
            ..::...::........|.::|    .|..:..::.......:|     |.|.::..|:|:    
Human   191 AAINAAIIEIATNHSVMEQLMSVTGVHMKILPFVAQGGVATDFF-----IFFCIISFSTFIYYVS 250

  Fly   241 VPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYT-LLMIFVLVVAYLYKALGSIC---FAY 301
            |...:|:|     ::..:..|..|....|:|...:.|. .::|...::|.:.|:...:.   |..
Human   251 VNVTQERQ-----YITSLMTMMGLRESAFWLSWGLMYAGFILIMATLMALIVKSAQIVVLTGFVM 310

  Fly   302 VAVLFLLYILSTMSYAYLISICFHSVFYAKIGGLAMLIIPYAFSFVRSWATSLAFVCFSTN--TF 364
            |..|||||.||.::.|:|:|:.....|      |..|::   |..:..|.. |.|....|.  .|
Human   311 VFTLFLLYGLSLITLAFLMSVLIKKPF------LTGLVV---FLLIVFWGI-LGFPALYTRLPAF 365

  Fly   365 LE-GLDIFQTFSNKRKNREFGAVDVFRV---IKSNS------------STMFSVYVVLVFQSFLY 413
            || .|.:...|:     ...|...:..:   :.||:            :|:|    :|||.:.||
Human   366 LEWTLCLLSPFA-----FTVGMAQLIHLDYDVNSNAHLDSSQNPYLIIATLF----MLVFDTLLY 421

  Fly   414 AMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQR-------NEYTTTPR-------------GT 458
            .:|..|...:.|...|.:....|||....:.:..|       ||..:.|.             |.
Human   422 LVLTLYFDKILPAEYGHRCSPLFFLKSCFWFQHGRANHVVLENETDSDPTPNDCFEPVSPEFCGK 486

  Fly   459 HAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIV 523
            .||.|..|.|::............:...|...:||.||||:||||||::|::.||....||.:.|
Human   487 EAIRIKNLKKEYAGKCERVEALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTSGSVTV 551

  Fly   524 CSE-----RDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGLS 583
            .:.     .|:.:.....|||||.:|...::|..::|..||:::|....:........:::|.:.
Human   552 YNHTLSRMADIENISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPHEVEKEVQRVVQELEME 616

  Fly   584 DKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTT 648
            :.::...:|||||..|:|:.||||.|:.::::||||::|||..||..:|::|...:.::.:|.:|
Human   617 NIQDILAQNLSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKEGKSDRVILFST 681

  Fly   649 HYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEIMEIIHHFVPTA 713
            .:::||::|.|....::||||:..||.|.||:|.||||.|.|.:|:....| .|..::...:..|
Human   682 QFIDEADILADRKVFISNGKLKCAGSSLFLKKKWGIGYHLSLHLNERCDPE-SITSLVKQHISDA 745

  Fly   714 RVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAG-----EQD 773
            ::.......:...||....|.|.: |||........||....::.|:|.:|||:..|     |.|
Human   746 KLTAQSEEKLVYILPLERTNKFPE-LYRDLDRCSNQGIEDYGVSITTLNEVFLKLEGKSTIDESD 809

  Fly   774 -----QVDTPDGSRNDAPLLAHYKRLQD-HPPHRGL--FQLW----MAVFYKKWTFISNE--WLY 824
                 |:.| ||:::...|:...:.|.. |...:.:  ..||    .|:...::..:..|  .|:
Human   810 IGIWGQLQT-DGAKDIGSLVELEQVLSSFHETRKTISGVALWRQQVCAIAKVRFLKLKKERKSLW 873

  Fly   825 TLIMLCIPFVCVFGAILVMHAMSLVEN------EEALPLKLSQMGSGVIYVHNPTGHHAHLEQQL 883
            |:::|       ||   :.....|:|:      :::.|.:||           |..:.....||.
Human   874 TILLL-------FG---ISFIPQLLEHLFYESYQKSYPWELS-----------PNTYFLSPGQQP 917

  Fly   884 RQQIELNGITAKTMHLRGSNDVKNESLDLQRDNLADFLEQVIGIIDMYGGGRGTSDTPTIE--IF 946
            :..:....:..||    ||. :.|....|:|.|:|  :|     :|.:|...||.| |:..  |.
Human   918 QDPLTHLLVINKT----GST-IDNFLHSLRRQNIA--IE-----VDAFGTRNGTDD-PSYNGAII 969

  Fly   947 YSGN-------------RYHSSVELINLVDSAMLKLGRPESEIDTTYVPIRRFVSDISPSRLEY- 997
            .||:             |.:....|::::.:.:|.:......|.|..       |......::| 
Human   970 VSGDEKDHRFSIACNTKRLNCFPVLLDVISNGLLGIFNSSEHIQTDR-------STFFEEHMDYE 1027

  Fly   998 YA------VIVPIGMFFFMFYFISL--PFREYANGFKQLQTMSRFTYWFAHFTFDMLILIFVCVA 1054
            |.      ..:|:...|..:..:|.  .:::.|:...::..:....|||.....|:.:...:.:.
Human  1028 YGYRSNTFFWIPMAASFTPYIAMSSIGDYKKKAHSQLRISGLYPSAYWFGQALVDVSLYFLILLL 1092

  Fly  1055 LFSLQSLMMPSE-LYTTAELKVIVLSIFFYGCSYLPILYALG---NNFKSISTISTYLLLMLIVS 1115
            :..:..:..|.| ::....|.:.:|....|..|.:.:.|.:.   .|.:..|.|.::..|::::.
Human  1093 MQIMDYIFSPEEIIFIIQNLLIQILCSIGYVSSLVFLTYVISFIFRNGRKNSGIWSFFFLIVVIF 1157

  Fly  1116 AIAPLITSSNAAAMKLHETKIAFLCF----LPDFNLNHQFRIINENFITRRHPALIKGLISQDTF 1176
            :|         .|..|:|.....|.|    :|.|.|.....|.:|     ..|..:..|.:.::.
Human  1158 SI---------VATDLNEYGFLGLFFGTMLIPPFTLIGSLFIFSE-----ISPDSMDYLGASESE 1208

  Fly  1177 FAY-ATAVGVMVMAFFTIVLE------HKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDD 1234
            ..| |..:..:....|..:|.      .|.|.|:  |.::..:   .:.|:....|..|..|.:|
Human  1209 IVYLALLIPYLHFLIFLFILRCLEMNCRKKLMRK--DPVFRIS---PRSNAIFPNPEEPEGEEED 1268

  Fly  1235 CAREEKR------VTDLIKDPLNDHSLIVHNLRKRYG-----------DKLAVDGVSFAAAQGEC 1282
            ...|..|      |.|..:.|:    :|...|||.|.           .|:|...|||...:||.
Human  1269 IQMERMRTVNAMAVRDFDETPV----IIASCLRKEYAGKKKNCFSKRKKKIATRNVSFCVKKGEV 1329

  Fly  1283 FGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQC 1347
            .||||.|||||::|.:||..:.....|.:.:||:...|.    ..:.|||||.:||...:|..|.
Human  1330 IGLLGHNGAGKSTTIKMITGDTKPTAGQVILKGSGGGEP----LGFLGYCPQENALWPNLTVRQH 1390

  Fly  1348 LYYMALLRGLSRRRTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPAL 1412
            |...|.::||  |:.|...:    :...::.:.|....|..|:..|.|.||||...::::|.|::
Human  1391 LEVYAAVKGL--RKGDAMIA----ITRLVDALKLQDQLKAPVKTLSEGIKRKLCFVLSILGNPSV 1449

  Fly  1413 VLLDEPTTGVDPISRRFLWQCIK-DFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNIC 1476
            ||||||:||:||..::.:||.|: .|:..:|..:||:|.|.|.|.:|:|:|||..|:.:|:.:|.
Human  1450 VLLDEPSTGMDPEGQQQMWQVIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQ 1514

  Fly  1477 ALKRLSGFTIKLKMKADTETEMNVSTITGTLKSE----FPGLELRESHAGTLTYFVSTQESVVLW 1537
            .||...|....|:||.....:|.      .|.:|    ||....:|..:..:.|.:..::...|.
Human  1515 HLKSKFGKDYLLEMKLKNLAQME------PLHAEILRLFPQAAQQERFSSLMVYKLPVEDVRPLS 1573

  Fly  1538 SSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFERE 1576
            .:.||:  |.:  :.|..:.:||:::.|||.:||:..:|
Human  1574 QAFFKL--EIV--KQSFDLEEYSLSQSTLEQVFLELSKE 1608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EatoNP_001036360.1 ABC2_membrane_3 <209..347 CDD:289468 32/145 (22%)
CcmA 460..767 CDD:224054 99/311 (32%)
ABC_subfamily_A 461..679 CDD:213230 72/222 (32%)
ABC2_membrane_3 <937..1117 CDD:289468 33/207 (16%)
ABC_subfamily_A 1255..1479 CDD:213230 83/235 (35%)
drrA 1262..1573 CDD:130256 105/326 (32%)
ABCA9XP_024306297.1 ABC2_membrane_3 53..416 CDD:315386 85/413 (21%)
AAA <245..1609 CDD:333001 372/1475 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148379
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0059
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.650

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