DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and ABCA10

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001364250.1	Gene:	ABCA10 / 10349	HGNCID:	30	Length:	1543	Species:	Homo sapiens

Alignment Length:	1597	Identity:	384/1597 - (24%)
Similarity:	667/1597 - (41%)	Gaps:	326/1597 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 YIRSGFLSLQHILDKQYMKYQELGKDFEVVVSSMP-NMEV---ISMDSHRLTYFGTLCSILFNVV 234
            |...||::.|..::...::........|.:.|.:. ||::   ||.......:|...|.:.|
Human    83 YWLKGFVAFQAAINAAIIEVTTNHSVMEELTSVIGINMKIPPFISKGEIMNEWFHFTCLVSF--- 144

  Fly   235 LLSSFVVPFVE---EKQNGLKEFLNLVTPMSFLNGLTFFL---IRFVCYTLLM-IFVLVVAYLYK 292
              |||:. |..   .::.|  :|..|:|.|. |....|:|   :.::|:..:| ||:.:|.....
Human   145 --SSFIY-FASLNVARERG--KFKKLMTVMG-LRESAFWLSWGLTYICFIFIMSIFMALVITSIP 203

  Fly   293 ALGSICFAYVAVLFLLYILSTMSYAYLISICFHSVFYAKIGGLAMLI-------------IPYAF 344
            .:....|..:..|:.||.||.::.|:|:|:.......|.:.|....:             :|.:.
Human   204 IVFHTGFMVIFTLYSLYGLSLIALAFLMSVLIRKPMLAGLAGFLFTVFWGCLGFTVLYRQLPLSL 268

  Fly   345 SFVRSWATSLAFVC-----FSTNTFLEGLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYV 404
            .:|.|..:..||..     ...:.:|.|:                   :|.....:|..|.:.:.
Human   269 GWVLSLLSPFAFTAGMAQITHLDNYLSGV-------------------IFPDPSGDSYKMIATFF 314

  Fly   405 VLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRNEY------------------ 451
            :|.|.:..|.:...|...|.|...|......|||....:.|.|...:
Human   315 ILAFDTLFYLIFTLYFERVLPDKDGHGDSPLFFLKSSFWSKHQNTHHEIFENEINPEHSSDDSFE 379

  Fly   452 TTTP--RGTHAIIITELCKKF--QTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMG 512
            ..:|  .|..||.|..:.|::  :|.|.:.|  ..:...|...:||.:||||||||:|::|::.|
Human   380 PVSPEFHGKEAIRIRNVIKEYNGKTGKVEAL--QGIFFDIYEGQITAILGHNGAGKSTLLNILSG 442

  Fly   513 LVPKDSGKIIVCSER-----DVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDW 572
            |.....|...:.:.:     |:...|..||||||.:....::|..::|..||:::|....:....
Human   443 LSVSTEGSATIYNTQLSEITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQPKEVEQE 507

  Fly   573 ADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLN 637
            ....:.:|.:...::...|.||||.||:|:|||||.|:.::::||||::|||..||..:|.:|..
Human   508 VKRIIMELDMQSIQDIIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKE 572

  Fly   638 LRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREVEI 702
            .:.::.:|.:|.:|:||::|.|....|:||||:..||.|.||||.||||.|.|..|:....| :|
Human   573 HKVDRLILFSTQFMDEADILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTE-KI 636

  Fly   703 MEIIHHFVPTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLR 767
            ..:|...:|.|::.......:...||....|.|..:...|: :..:.||...:::.|||.:|||.
Human   637 TSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPDLYSDLD-KCSDQGIRNYAVSVTSLNEVFLN 700

  Fly   768 CAGEQDQVDTPD----------GSRNDAPLLAHYKRLQDHPPHRGLFQ---LWMAVFYKKWT--F 817
            ..| :..:|.||          .:||........:.|...|..|....   ||....|...|  |
Human   701 LEG-KSAIDEPDFDIGKQEKIHVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRF 764

  Fly   818 IS-----NEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLKLSQMGSGVIYVHNPTGHHA 877
            :.     ...|..|::|.|.|:    .|::...|..|..|..            .:..:|:.:..
Human   765 LKLRRERRALLCLLLVLGIAFI----PIILEKIMYKVTRETH------------CWEFSPSMYFL 813

  Fly   878 HLEQQLRQQIELNGITAKTMHLRGSN------DVKNESLDLQRDNLADFLEQVIGIIDMYGGGRG 936
            .|||..:..:....|...|    |||      .:|.:.:.|:.|:..:               |.
Human   814 SLEQIPKTPLTSLLIVNNT----GSNIEDLVHSLKCQDIVLEIDDFRN---------------RN 859

  Fly   937 TSDTPTIE--IFYSGNR--YHSSVE-----------LINLVDSAML--------------KLGRP 972
            .||.|:..  |..||::  |..||.           |:.:|.:|::              ...|.
Human   860 GSDDPSYNGAIIVSGDQKDYRFSVACNTKKLNCFPVLMGIVSNALMGIFNFTELIQMESTSFSRD 924

  Fly   973 ESEIDTTY-----------------------------VPIRRFVSDISPSRLEYYAVIVPIGMFF 1008
            :..:|..:                             |..:.::|.:.||.......:|.|.::|
Human   925 DIVLDLGFIDGSIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYF 989

  Fly  1009 -------FMFYFISLPFREYANGFKQLQTMSRFTYWFAHFTFDMLILIFVCVALFSLQSLMMPSE 1066
                   .::|||.|.|:                     .:::::.::.||:
Human   990 LILFSIHLIYYFIFLGFQ---------------------LSWELMFVLVVCI------------- 1020

  Fly  1067 LYTTAELKVIVLSIFF-YGCSYLPILYALGNNFKSISTISTYLLLMLIVSAIAPLITSSNAAAMK 1130
                  :...|..||. |..|::...:...|.|.|..    :.::::.||.|   :.|:....:.
Human  1021 ------IGCAVSLIFLTYVLSFIFRKWRKNNGFWSFG----FFIILICVSTI---MVSTQYEKLN 1072

  Fly  1131 LHETKIAFLCFLPDFN-LNHQFRIINENFITRRHPAL------IKGLISQDTFFAYATAVGVMVM 1188
            |    |..:.|:|.|. |.:...:|..:|: |...:|      :...|...|...|..:|   :.
Human  1073 L----ILCMIFIPSFTLLGYVMLLIQLDFM-RNLDSLDNRINEVNKTILLTTLIPYLQSV---IF 1129

  Fly  1189 AFFTIVLEHKYLRRRIH-DGIWEWAFQRKKYNSTGTLPSTPISEIDDCAREEKRVTDLIKDP-LN 1251
            .|....||.||....:: |.::..:   .:...|...|..|..|.:|...|..:..:.:..| |.
Human  1130 LFVIRCLEMKYGNEIMNKDPVFRIS---PRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLE 1191

  Fly  1252 DHSLIVHN-LRKRYGD-----------KLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANL 1304
            :..:|..: |.|.|.:           |:|:..|||...:||..||||.|||||:::.:||....
Human  1192 EEPVITASCLHKEYYETKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCT 1256

  Fly  1305 PLDGGTIRIKG--ADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPAS 1367
            ....|.:.::|  |.:|:......::.|||||.::|...:|.::.|...|.::||.:.  |...|
Human  1257 KPTAGVVVLQGSRASVRQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKE--DAALS 1319

  Fly  1368 CKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQ 1432
                :...:|.:.|.:..|..|:..|.|.||||...::::|.|::||||||.||:||..::.:||
Human  1320 ----ISRLVEALKLQEQLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQ 1380

  Fly  1433 CIK-DFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKRLSG--FTIKLKMKADT 1494
            .:: ..:.|:|..:||:|.|.|.|.:|:|:|:|..|..:|:.:|..||...|  :.:::|||..|
Human  1381 ILQATVKNKERGTLLTTHYMSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMKEPT 1445

  Fly  1495 ETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSAL---- 1555
            :.|   :..|..||. ||....:|.::..:.|.:..::...|..:.||         |.|:
Human  1446 QVE---ALHTEILKL-FPQAAWQERYSSLMAYKLPVEDVHPLSRAFFK---------LEAMKQTF 1497

  Fly  1556 -VADYSVNECTLEDIFLKF--EREAKSQSTSRQTSVQ 1589
             :.:||:::.|||.:||:.  |:|..:......|:|:
Human  1498 NLEEYSLSQATLEQVFLELCKEQELGNVDDKIDTTVE 1534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	36/160 (23%)
		CcmA	460..767	CDD:224054	105/313 (34%)
		ABC_subfamily_A	461..679	CDD:213230	76/224 (34%)
		ABC2_membrane_3	<937..1117	CDD:289468	38/245 (16%)
		ABC_subfamily_A	1255..1479	CDD:213230	78/238 (33%)
		drrA	1262..1573	CDD:130256	103/331 (31%)
ABCA10	NP_001364250.1	rim_protein	<37..1520	CDD:130324	380/1581 (24%)
ABCA10	NP_001364250.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1153..1177		5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650