Protein Alignment Eato and ABCA7

DIOPT Version :9

• Sequence 1: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: XP_024307083.1
• Gene: ABCA7 / 10347
• HGNCID: 37
• Length: 2151
• Species: Homo sapiens
• Alignment Length: 1771
• Identity: 463/1771 - (26%)
• Similarity: 727/1771 - (41%)
• Gaps: 420/1771 - (23%)

  Fly   131 HRVPNRGSDR---KFRYSLSSNQMRISPRKRFVNDEEIYHQIDDDDYIRSGFLSLQHILDK---- 188
            |..|:.|...   |.|..:.........|.||.:.......:.|..|:..||:.||.::::
Human   452 HPTPDLGPGHVRIKIRMDIDVVTRTNKIRDRFWDPGPAADPLTDLRYVWGGFVYLQDLVERAAVR 516

  Fly   189 -------------QYMKYQELGKD--FEVVVSSMPNMEVISMDSHRLTYFGTLCSILFNVVLLSS 238
                         |.|.|.....|  ..|:..|:|             .|.||..| ::|.|.
Human   517 VLSGANPRAGLYLQQMPYPCYVDDVFLRVLSRSLP-------------LFLTLAWI-YSVTLT-- 565

  Fly   239 FVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLI---RFVCYTLLMIFVLVVAYLYKALGSIC-F 299
             |...|.||:..|::.:..:.....:..|.:||.   .|:....|::.||       .||.|. :
Human   566 -VKAVVREKETRLRDTMRAMGLSRAVLWLGWFLSCLGPFLLSAALLVLVL-------KLGDILPY 622

  Fly   300 AYVAVLFLL---YILSTMSYAYLISICF-HSVFYAKIGGLA--MLIIPYAFSFVRSW-------- 350
            ::..|:||.   :.::|::.::|:|..| .:...|..||||  .|.:||....  :|
Human   623 SHPGVVFLFLAAFAVATVTQSFLLSAFFSRANLAAACGGLAYFSLYLPYVLCV--AWRDRLPAGG 685

  Fly   351 ---ATSLAFVCFSTNTFLEGLDIFQTFSNKRKNREFG---AVDVFRVIKSNSSTMFSVYVVLVFQ 409
               |:.|:.|.|...  .|.|.:.:......:....|   ..|||        ::..|..:|:..
Human   686 RVAASLLSPVAFGFG--CESLALLEEQGEGAQWHNVGTRPTADVF--------SLAQVSGLLLLD 740

  Fly   410 SFLYAMLYNYLGCVFPGPGGLKRPMFF-F--------------------LDPKTYMKRQRNEYTT 453
            :.||.:...||..|.||..|:..|..| |                    ||||..::.
Human   741 AALYGLATWYLEAVCPGQYGIPEPWNFPFRRSYWCGPRPPKSPAPCPTPLDPKVLVEE------- 798

  Fly   454 TPRG-THAIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKD 517
            .|.| :..:.:..|.|:|..|.:..|  ..|::......||..||||||||||.::::.||.|..
Human   799 APPGLSPGVSVRSLEKRFPGSPQPAL--RGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPS 861

  Fly   518 SGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKK 579
            .|...:..   ...:|:.|..:|.|||::|....:|..:|:.|:.:|:|...:......|..|:.
Human   862 GGSAFILGHDVRSSMAAIRPHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQD 926

  Fly   580 LGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAV 644
            :||..|::...::|||||:|:||:.||..|.:::||||||::|:|..|||.:|::||..|:.:.:
Human   927 VGLVSKQSVQTRHLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTL 991

  Fly   645 LVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGY-------RLKLEINDFTSREVE- 701
            :::||:::|||:|||.:.::|.|:|...||||.|:|..|.||       ||.|..|:....::|
Human   992 ILSTHHLDEAELLGDRVAVVAGGRLCCCGSPLFLRRHLGSGYYLTLVKARLPLTTNEKADTDMEG 1056

  Fly   702 ---------------------IMEIIHHFVPTARVLNVVNPTVYICLPY--AYKNCFAQMLYRLE 743
                                 ::.::.|:||.||::..:...:.:.|||  |:...||.:...|:
Human  1057 SVDTRQEKKNGSQGSRVGTPQLLALVQHWVPGARLVEELPHELVLVLPYTGAHDGSFATLFRELD 1121

  Fly   744 TESKELGIHTISMTDTSLEDVFLR----CAGEQDQVDTPDGS----------------------- 781
            |...||.:....::|||||::||:    ||.:.|..|...|.
Human  1122 TRLAELRLTGYGISDTSLEEIFLKVVEECAADTDMEDGSCGQHLCTGIAGLDVTLRLKMPPQETA 1186

  Fly   782 -RNDAPLLAHYKRLQDHPPHR-GLFQLW-------MAVFYKKWTFI--SNEWLYTLIMLCIPFVC 835
             .|..|..:..:..|...|.. |..|.|       .|:..|::...  |...|:..|:|...||
Human  1187 LENGEPAGSAPETDQGSGPDAVGRVQGWALTRQQLQALLLKRFLLARRSRRGLFAQIVLPALFV- 1250

  Fly   836 VFGAILVMHAMSLV----ENEEALPLKLSQMGSGVIYVHN------------------------P 872
              |..||   .||:    .:..||.|..:..|:.|.:...                        |
Human  1251 --GLALV---FSLIVPPFGHYPALRLSPTMYGAQVSFFSEDAPGDPGRARLLEALLQEAGLEEPP 1310

  Fly   873 TGHHAHLEQQLRQQIELNGITAK-----------------------------------TMHLRGS 902
            ..|.:|.........|:..:.|.                                   ...:.||
Human  1311 VQHSSHRFSAPEVPAEVAKVLASGNWTPESPSPACQCSRPGARRLLPDCPAAAGGPPPPQAVTGS 1375

  Fly   903 NDVKNESLDLQRDNLADFLEQVI------GIID-------MYGG----------------GRGTS 938
            .:|..   :|...||:|||.:..      |:..       .|||                ||...
Human  1376 GEVVQ---NLTGRNLSDFLVKTYPRLVRQGLKTKKWVNEVRYGGFSLGGRDPGLPSGQELGRSVE 1437

  Fly   939 D-----TP------------------------TIEIFYSGNRYHSSVELINLVDSAMLKLGRPES 974
            :     :|                        :::|:::...:||.|..:|...:|:|:...|..
Human  1438 ELWALLSPLPGGALDRVLKNLTAWAHSLDAQDSLKIWFNNKGWHSMVAFVNRASNAILRAHLPPG 1502

  Fly   975 ------EIDTTYVPIRRFVSDISPSRL--EYYAVIVPIGMFFFMFY----FISLPFREYANGFKQ 1027
                  .|.|...|:......:|...|  ....|:|.|.:.|.|.:    |..:...|.....|.
Human  1503 PARHAHSITTLNHPLNLTKEQLSEGALMASSVDVLVSICVVFAMSFVPASFTLVLIEERVTRAKH 1567

  Fly  1028 LQTM---SRFTYWFAHFTFDM---------LILIFVCVALFSLQSLMMPSELYTTAELKVIVLSI 1080
            ||.|   |...||..:|.:||         ::|||:.   |..::.:.|      |.|..::|.:
Human  1568 LQLMGGLSPTLYWLGNFLWDMCNYLVPACIVVLIFLA---FQQRAYVAP------ANLPALLLLL 1623

  Fly  1081 FFYGCSYLPILYALGNNFKSISTISTYLLLMLIVSAIAPLITSSNAAAMKLHETKIAFLCFLPDF 1145
            ..||.|..|::|.....|...||  .|::|..|...|.  |..|.|..:         |....|.
Human  1624 LLYGWSITPLMYPASFFFSVPST--AYVVLTCINLFIG--INGSMATFV---------LELFSDQ 1675

  Fly  1146 NLNHQFRIINENFITRRHPALIKGLISQDTFFAYATA-----------------VGVMVMA---- 1189
            .|....||:.:.|:...|..|.:|||......|.|.|                 ||..::|
Human  1676 KLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDRQFQSPLRWEVVGKNLLAMVIQ 1740

  Fly  1190 -----FFTIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEIDDCAREEKRVTDLIKDP 1249
                 .||::|:|   |.::   :.:::..|.:..|...|.    .|.:|.|||.:||   ::..
Human  1741 GPLFLLFTLLLQH---RSQL---LPQYSVPRPRVRSLPLLG----EEDEDVARERERV---VQGA 1792

  Fly  1250 LNDHSLIVHNLRKRY-GDKL-AVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIR 1312
            .....|::.||.|.| |.:: |||.:......||||||||||||||||||:|:..:.....|...
Human  1793 TQGDVLVLRNLTKVYRGQRMPAVDRLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASRGEAV 1857

  Fly  1313 IKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYWLE 1377
            :.|..:...........|||||.||:.:.:|..:.|..:|.|||:..      |...:.....|.
Human  1858 LAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPE------AQVAQTAGSGLA 1916

  Fly  1378 KMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDR 1442
            ::.|:.|.......||||.||||..|:|::|.||:|.|||||||:||.:|||||..:.....:.|
Human  1917 RLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGR 1981

  Fly  1443 TVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKR--LSGFTIKLKMKADTETEMNVSTITG 1505
            :|:||||||:|||.||:|||||.:|:|:||.:...||.  .:|.|:.|::.|     ........
Human  1982 SVMLTSHSMEECEALCSRLAIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPA-----ARSQPAAA 2041

  Fly  1506 TLKSEFPGLELRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIF 1570
            .:.:||||.||||:|.|.|.:.:.......|    .::..|.........|.|:||::..||::|
Human  2042 FVAAEFPGAELREAHGGRLRFQLPPGGRCAL----ARVFGELAVHGAEHGVEDFSVSQTMLEEVF 2102

  Fly  1571 LKFER-EAKSQSTSRQ 1585
            |.|.: :.|.:.|..|
Human  2103 LYFSKDQGKDEDTEEQ 2118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	36/147 (24%)
		CcmA	460..767	CDD:224054	111/340 (33%)
		ABC_subfamily_A	461..679	CDD:213230	80/220 (36%)
		ABC2_membrane_3	<937..1117	CDD:289468	50/232 (22%)
		ABC_subfamily_A	1255..1479	CDD:213230	97/225 (43%)
		drrA	1262..1573	CDD:130256	121/314 (39%)
ABCA7	XP_024307083.1	rim_protein	1..2114	CDD:130324	461/1765 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148324
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.660