DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and LOC101883122

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	XP_021333309.1	Gene:	LOC101883122 / 101883122	-ID:	-	Length:	2391	Species:	Danio rerio

Alignment Length:	1593	Identity:	365/1593 - (22%)
Similarity:	613/1593 - (38%)	Gaps:	468/1593 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 IDDDDYIRSGFLSLQHILDKQYMKYQE-LGKDFEVVVSSMPNMEVISMDSHRLTYFGTLCS---- 228
            ::|..|:|.||:.||.::|:..:|.|. :.:...|....||  ....||...::..||:..
Zfish   511 LNDLRYVRGGFVYLQDMVDRAIIKLQTGVQQTLGVYAQQMP--YPCYMDDAFVSAIGTMLPMFLV 573

  Fly   229 ILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYTLLMIFVLVVAYLYKA 293
            :.|| ..:|..:...|.||:..|||.|.       ::|::...||...:...||.::|..    |
Zfish   574 LAFN-YSVSEIIKGLVLEKERRLKEVLR-------VSGVSNSTIRLCWFAENMILLMVPC----A 626

  Fly   294 LGSICFAY-----------VAVLFLLYILSTMSYAYLISICF-HSVFYAKIGGLA--MLIIP--- 341
            |.|:...|           :.|..|::.|:|:...:.||:.| .:...|..|||.  :|.:|
Zfish   627 LISVMVKYGKVLRYSDPSVIFVFLLVFCLATVMQCFFISVFFSRANLAAACGGLLYFLLYLPHVL 691

  Fly   342 -YAFSFVRSWATSLAFVCFSTNTFLEGLDIFQTF---------SNKRKNREFGAVDVFRVIKSNS 396
             ||:..|..:...:|....|...|..|.:.|.|:         ||.|.:.:           .|.
Zfish   692 CYAWRDVLGFGAKIATSLLSCVAFGYGCENFSTYEAQGVGIQWSNIRSSPQ-----------DND 745

  Fly   397 STMFSVYV-VLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTY----------------- 443
            ...|.|.: :::|.:.:|..|..|:..|:||..|:.:|.:|   |.|.
Zfish   746 RYSFIVSIFMMLFDALIYWTLTWYIENVYPGQYGIAKPWYF---PFTSSYWCGSRVGSDGHPDLL 807

  Fly   444 --MKRQRNEYTTTPRGTH-AIIITELCKKFQTSKRDTLISDNLNMTINNKEITVLLGHNGAGKTT 505
              ::.|.......|.|.. .:.|..|.|.::|..:  |..|.|::......||..||||||||||
Zfish   808 QDLENQSGFLEKPPSGLKPGVCIRNLVKVYKTGNK--LAVDGLSLDFYQDHITSFLGHNGAGKTT 870

  Fly   506 MMNMIMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRS 567
            .|:::.||....||...:..   ..|:...|..:|.||||:|....:|..:|:.|:|:|:|....
Zfish   871 TMSILTGLFAPTSGTAYINGYDIRTDMDCIRKQLGMCPQHNVLFDDLTVEEHIYFYARLKGRSSK 935

  Fly   568 DARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELW 632
            :.:...|:.:|.:||..||.:..|||||||:|:||:.||..|.:.:||||||::|:|..:||.:|
Zfish   936 EVKKEIDQMIKDVGLPHKRKDLAKNLSGGMQRKLSVAIAFVGGSNVVILDEPTAGVDPYARRGIW 1000

  Fly   633 DILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKL------- 690
            ::||..::.:.::::||:|:||::|||.:.|:::|::|..||.|.||:..|.||.|.:
Zfish  1001 ELLLKYKQGRTIILSTHHMDEADILGDRVAIISHGRVQCCGSSLFLKKTYGRGYYLTIARANQER 1065

  Fly   691 ------------------------EINDFTSREV-EIMEIIHHFVPTARVLNVVNPTVYICLPY- 729
                                    .|:.....:| ::..::...||.|..|..|...:...|||
Zfish  1066 APAQCVPSPEEFDQSSLDEGICSDSISSLDPPDVSDVSRLVRRHVPEAEFLEAVGQELVYVLPYS 1130

  Fly   730 -AYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQVDT---------PDGS--- 781
             |....||.:...|:.|...||:.:..::|||||::||:.| |...||.         |..|
Zfish  1131 GATNGSFATLFKELDLEKNTLGVTSYGISDTSLEEIFLKVA-EDTGVDVESHDKPKQKPRSSSRI 1194

  Fly   782 ------------------RNDAPLLAHYKRLQD-HPP----HRG---------LFQLWMAVFYKK 814
                              :|:|. :....|::| |.|    .:|         :.|.::|:|.|:
Zfish  1195 SGKQSISSALECRDAKTVKNEAK-VRFASRVEDTHRPMCANGKGSDVINGWSLIRQQFLALFIKR 1258

  Fly   815 WTFI--SNEWLYTLIMLCIPFVCVFGAILVMHAMSLVENEEALPLK-----------LSQMGSGV 866
            :...  |.:.:...:::...|||:  |::....:.......:|.|:           .|..|.||
Zfish  1259 FHHARRSRKGIIAQVVMPAFFVCL--ALIFSLIVPPFNEYPSLELQPWMYGAPQNTFYSFDGPGV 1321

  Fly   867 IYVHNPTGHHAHLEQQLRQQIELNGI-------TAKT-------------MHLRGSNDVKNESLD 911
            :.|...|....:......:.:..|.|       |..|             :..:|:..::|.|..
Zfish  1322 VQVEKVTNALLNSPGFGTRCMSTNPIPRLPCVSTGSTNWFTPAVDPSISDIFDKGNWTMQNPSPA 1386

  Fly   912 LQ-------------------------RDNLADFLEQVIG--IIDM------------YGG---- 933
            .|                         ..|..|.|:.|.|  :.|.            |||
Zfish  1387 CQCSTAERSFMLPDCPPGAGGLPPPQRTQNTTDTLQNVTGRNMTDFLLKTYQKSGKIRYGGFSVG 1451

  Fly   934 ------GRGTSDTPTI-----------------EIFYS--------GNR-----------YHSSV 956
                  ....||..|:                 :||.:        |.|           :||.|
Zfish  1452 GVNSQVRLNESDITTLVSDLRSVFNVSQFKQSEDIFQAIRLFLLELGTRDNMKVWFYNPGWHSLV 1516

  Fly   957 ELINLVDSAMLKLG-----RPESEIDTTY-VPIRRFVSDISPSRLEYYA--VIVPIGMFFFMFY- 1012
            ..:|:..:..|:..     |||....||: .|:......:|.:.|...:  |:|.|.:.|.|.:
Zfish  1517 SFLNVASNGALRGNLPAGRRPEDYGITTFNHPLNLTREQLSTAALASSSTDVVVAICVIFAMSFI 1581

  Fly  1013 ---FISLPFREYANGFKQLQTMSRFT---YWFAHFTFDM---------LILIFVCVALFSLQSLM 1062
               |:....:|.....|.||.:|...   ||.|:|.:||         :|:||:|   |..:|.:
Zfish  1582 PASFVLFLIQERVTKAKHLQFVSGVNPTIYWLANFAWDMCNYIVPCVIVIIIFLC---FQQKSYV 1643

  Fly  1063 MPSELYTTAELKVIVLSIFFYGCSYLPILYALGNNFKSISTISTYLLLMLIVSAIAPLITSSNAA 1127
            .|      ..|..::|.:..||.|..|::|.....|...||  .|::|..|...|.  |..|.|.
Zfish  1644 SP------PNLPALILLLALYGWSITPMMYPFSFVFSVPST--AYVVLTCINLFIG--INGSVAT 1698

  Fly  1128 -AMKLHETKIAFLCFLPDFNLNHQFRIINENFITRRHPALIKGL---------------ISQDTF 1176
             .|:|.:          |.|:.....|:.:..:...|..|.:||               :.:|.|
Zfish  1699 FVMELFD----------DPNITRINDIVKQALLVFPHFCLGRGLMDMAKNQAVATLYQNLGEDRF 1753

  Fly  1177 F-----------AYATAVGVMVMAFFTIVLEHKYLRRRIHDGIWEWAFQRKKYNSTGTLPSTPIS 1230
            .           .:|.::...||...|:::::|:.               .|..|..:..::...
Zfish  1754 VNPLTWNMVGKNLFAMSIQGAVMFAVTLLIQYKFF---------------CKPRSVKSPFTSSAE 1803

  Fly  1231 EIDDCAREEKRVTD----------------LIKDPLNDHSLIVHNLRKRYGDKLAV--------- 1270
            |.:|.|||.:||.:                |:|:|:  .::::....:..|...||
Zfish  1804 EDEDVARERERVYNGGAQKDLLHICDLTKVLLKNPV--LAVVLDQTLENTGFSSAVISNFLFNGP 1866

  Fly  1271 -----------------DGVSFAAAQ-----GECFGLLGVNGAGKTSTFQMIAANLPLD------ 1307
                             :..|.:|.|     ..|..||    .|.|.::...|.:.||:
Zfish  1867 ESERPAGMPSFDWRNVFNATSQSAQQLTQILKVCLHLL----KGVTKSWSPTARDNPLNDLRYVR 1927

  Fly  1308 GGTIRIKGADIREHEL------------KYREYFGY-CPQYDALNKFMTAEQCLYY-------MA 1352
            ||.:.::  |:.:..:            .|.:...| |...||..:.:|....||.       :|
Zfish  1928 GGFVYLQ--DMVDRAIIKLQTGVQQTLGVYAQQMPYPCYMDDAFLRSLTRSLPLYMTLAWIFSVA 1990

  Fly  1353 LL-RGLSRRRTDGPASCKEHVK--------YWL 1376
            |: :|:.:.:   .|..||.|:        |||
Zfish  1991 LIVKGVVQEK---EARLKETVRMMGLKSSTYWL 2020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	39/159 (25%)
		CcmA	460..767	CDD:224054	113/343 (33%)
		ABC_subfamily_A	461..679	CDD:213230	84/220 (38%)
		ABC2_membrane_3	<937..1117	CDD:289468	57/239 (24%)
		ABC_subfamily_A	1255..1479	CDD:213230	35/188 (19%)
		drrA	1262..1573	CDD:130256	35/181 (19%)
LOC101883122	XP_021333309.1	AAA	1..1833	CDD:333001	327/1393 (23%)
LOC101883122	XP_021333309.1	AAA	1835..>2372	CDD:333001	37/197 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010