DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Eato and abca1

DIOPT Version :9

Sequence 1:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	XP_004910916.1	Gene:	abca1 / 100491942	XenbaseID:	XB-GENE-1001143	Length:	2311	Species:	Xenopus tropicalis

Alignment Length:	2004	Identity:	475/2004 - (23%)
Similarity:	804/2004 - (40%)	Gaps:	561/2004 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 W-SVKPVLHQINQFEAKNEMVLRELYFPGNELDYIYYSPISPNVEDIMDLLRVDLGIIPERLRPN 107
            | ::||:|            |.:.||.|......:..|.::...:: :.:.| |||.:.|.:||.
Frog   376 WRALKPLL------------VGKILYTPSTPATQMLMSEVNKTFQE-LSVFR-DLGAMWEEVRPQ 426

  Fly   108 NNSFEMQLEMEQQCRGSCFAIDFHR--VPNRGS----DRKFR----------------------- 143
            ..:|   :|..|:       :|..|  :.|:||    |::..
Frog   427 IKNF---MESSQE-------MDLIRTLLTNKGSKTFLDQQLNSTGWTTENISRFLAKETADVETE 481

  Fly   144 ----YS-----------------------------LSSNQMRISPRKRFVNDE------------ 163
                ||                             :::.:|.|......:|:.
Frog   482 NGPFYSWREALNETDRVVLTLSRFMECVNLDKLEPVATEEMLIDKSMELLNERKFWAGIVFMDMP 546

  Fly   164 ----EIYHQI-------------------------------DDDDYIRSGFLSLQHILDKQYMKY 193
                |:.|.:                               :|..||..||..||.::::..::.
Frog   547 EEETELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYIWGGFSYLQDVVEQAIIRV 611

  Fly   194 QE-LGKDFEVVVSSMP-----NMEVISMDSHRLTYFGTLCSILFNVVLLSSFVVPFVEEKQNGLK 252
            |. :.|...:.|..||     :...:.:.|..:..|.||..|....|::...|.    ||:..||
Frog   612 QTGVEKRTGIYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIVY----EKEARLK 672

  Fly   253 EFLNLVTPMSFLNG---LTFFLIRFVCYTLLMIFVLVVAYLYKALGSICFAYVAVLFL---LYIL 311
            |.:.:   |...||   |::|:...:  .|||...|:|..| |....:.::..:|:|:   ::.:
Frog   673 ETMRI---MGLDNGILWLSWFISSLI--PLLMSAALLVLIL-KTGNLLPYSDPSVVFVFLSVFAV 731

  Fly   312 STMSYAYLISICF-HSVFYAKIGGLA--MLIIPYAFSFVRSWATSLAFVCFSTNTFLE------G 367
            .|:|..:|||..| .:...|..||:.  .|.:||....  :|...:.:......:||.      |
Frog   732 VTISQCFLISTIFSRANLAAACGGIIYFTLYLPYVLCV--AWQDYVGYTLKIFASFLSPVAFGFG 794

  Fly   368 LDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSVYVVLVFQSFLYAMLYNYLGCVFPGPGGLKR 432
            .::|.....:....::..: :...::.|...:.:...:::|.:.||.::..|:..||||..|:.|
Frog   795 CEVFALLEEQGVGVQWDNL-LESPLEENGYNITTSGFMMLFDTLLYGIMTWYIEAVFPGQYGIPR 858

  Fly   433 PMFFFLDPKTYMKRQRNEYT---TTPRGTHAIIITE-------------LCKKFQTSKRDTLISD 481
            |.:|......:...:..||.   |..:|:..:.:.|             |.|.::..|:  :..|
Frog   859 PWYFPFTKSYWCGEECKEYNQPHTVQKGSSEVCMEEEPSHLPLGVSIQNLVKIYRNGKK--VAVD 921

  Fly   482 NLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGKIIVCSE---RDVASYRHLIGFCPQHS 543
            .|.:.....:||..||||||||||.|:::.||.|..:|...:..:   .::.|.|..:|.||||:
Frog   922 GLTLNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTTGTAYIMKKDIRTELNSIRQNLGVCPQHN 986

  Fly   544 VFMSYMTCHQHLEFFAQLRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIA 608
            |....:|..:|:.|:|:|:|......:...::.:..:||..|:......|||||:|:||:.:|..
Frog   987 VLFDALTVEEHIWFYARLKGLSEEKVKAEMEQMVNDVGLPHKKKYKTSQLSGGMQRKLSVALAFV 1051

  Fly   609 GNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIG 673
            |.:|:||||||::|:|..|||.:|::|:..|:.:.::::||:|:||::|||.|.|:::|||..:|
Frog  1052 GGSKVVILDEPTAGVDPYSRRGIWELLIKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVG 1116

  Fly   674 SPLELKRKSGIGYRLKLEINDFTS----------------------------------------- 697
            |.|.||.:.|.||.|.|...|..|
Frog  1117 SSLFLKNQLGTGYYLTLVKRDNDSSLSSCRNSSSTMSYLKKESSKQTACKQHPSPMIAAPSASGT 1181

  Fly   698 ----------------REVE---------------------------------IMEIIHHFVPTA 713
                            :|.:                                 |..:|:..||.|
Frog  1182 TAAVITKHSKHTAGQKKEAKDREDSVSQSSSDAGLGSDHESDTMTIGLTDVSAISNLINKHVPEA 1246

  Fly   714 RVLNVVNPTVYICLPY--AYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQDQVD 776
            |::..:...:...|||  |.:..|.::.:.::....:|||.:..:.||:||::||:.|.     |
Frog  1247 RLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGIADTTLEEIFLKVAD-----D 1306

  Fly   777 T-PDGSRNDAPLLAHYKR--LQDH---------------------PPHR-----------GLFQ- 805
            | .|...:|..|.|..||  ..||                     |..|           |.:|
Frog  1307 TGVDAETSDGTLPARRKRYAFGDHQSCLRPFTEDDAFDTNDSDMDPESRETDYLSGIDGKGSYQL 1371

  Fly   806 -------------LWMAVFYKKWTFISNEWLYTLIMLCIPFVCV----------FGAILVMHAMS 847
                         ||..:.|.|   .|.:..:..|:|...||.:          ||....:....
Frog  1372 KSWNLMRQQFTALLWKRLLYAK---RSRKGFFAQIVLPAVFVLIALVFSLIVPPFGKYPSLELEP 1433

  Fly   848 LVENEE----------------ALPLKLSQMGSGVIYVHNPTGH--------------HAHLEQQ 882
            .:.:|:                .|...:.:.|.|...:.   ||              ......|
Frog  1434 WMYDEQYTFFSNDAPDDQGTQALLKALIDKPGFGTACME---GHSVMKVSCSGEEEEWSTQFVSQ 1495

  Fly   883 LRQQIELNG---ITAKTMHLRGSNDVKNESLDL------------QRDNLADFLEQVIG------ 926
            ....:.|||   :...:.....|:|.:.:.|.:            :|.|.:|.|:.:.|
Frog  1496 SVMDLFLNGNWTMENPSPSCECSSDKRKKMLPICPPGAGGLPPFQRRQNTSDILQNLTGRNISDY 1560

  Fly   927 -------IID------------MYGG-GRGTSDTP------------------------------ 941
                   ||:            .||| ..|.|::|
Frog  1561 LVKTYSQIIEKSLKNKIWVNEFRYGGFSLGASNSPALPPNEEVVASINHIKKRLELPQNGAANRF 1625

  Fly   942 ---------------TIEIFYSGNRYHSSVELINLVDSAMLKLGRPESEIDTTY-VPIRRFVSDI 990
                           .::::::...:|:....:|::::|:|:....|.|...:| :.......::
Frog  1626 LDSFGAFMKGLDTKDNVKVWFNNKGWHAVGAFLNVMNNAILRSKLREGEDPASYGITAFNHPLNL 1690

  Fly   991 SPSRLEYYA-------VIVPIGMFFFMFY----FISLPFREYANGFKQLQTMS---RFTYWFAHF 1041
            :..:|...|       |:|.|.:.|.|.:    |:....:|..:..|.:|.:|   ...||.|:|
Frog  1691 TKEQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHMQCISGVKPVIYWLANF 1755

  Fly  1042 TFDM---------LILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIFFYGCSYLPILYALGNN 1097
            .:||         :|:||:|   |...|.:      :::.|.|:.|.:..||.|..|::|.....
Frog  1756 VWDMCNYVVPATLVIIIFIC---FQQDSYV------SSSNLPVLALLLLLYGWSITPLMYPASFI 1811

  Fly  1098 FKSIST----ISTYLLLMLIVSAIAPLITS--SNAAAMKLHETKIAFLCFLPDFNL--------- 1147
            ||..||    :::..|.:.|..::|..:..  :|.....::|...:.|...|.|.|
Frog  1812 FKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLSNINEILKSVLLIFPHFCLGRGLIDMVK 1876

  Fly  1148 NHQFRIINENFITRRHPALIK-GLISQDTFFAYATAVGVMVMAFFTIVLEHKYLRRRIHDGIWEW 1211
            |.......|.|...|..:.:. .|:.::.|     |:.|..:.||.|.|..:|
Frog  1877 NQAMADALERFGENRFVSPMSWDLVGRNLF-----AMAVEGVVFFAITLMIQY------------ 1924

  Fly  1212 AFQRKKYNSTGTLPSTPISEIDDCAREEKRVTDLIKDPLNDHSLIVHNLRK--RYGDKLAVDGVS 1274
            .|..|.......||.. :.|.:|.|||.:|:.:..::.:    |.:..|.|  |...|.|||.:.
Frog  1925 RFFIKPRPVNAKLPPV-VDEDEDVARERQRINEGGRNDI----LELKGLTKIYRMKRKPAVDRLC 1984

  Fly  1275 FAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALN 1339
            .....|||||||||||||||:||:|:..:..:..|...:|...|..:..:..:..|||||:||:|
Frog  1985 VGIPPGECFGLLGVNGAGKTTTFKMLTGDTDVTAGEAFLKNHSILRNIHEVHQNMGYCPQFDAIN 2049

  Fly  1340 KFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYW-LEKMHLTKYQKVQVRHYSGGTKRKLLAA 1403
            :.:|..:.|...|||||:..:..     ||  |..| :.|:.|.||.:....:||||.||||..|
Frog  2050 ELLTGREHLELYALLRGVPEKEV-----CK--VAEWAIRKLGLVKYSEKHAGNYSGGNKRKLSTA 2107

  Fly  1404 MAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGK 1468
            :|:||.|.:|.|||||||:||.:|||||.|......:.|:||||||||:|||.||.|:|||.:|:
Frog  2108 IALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVIKEGRSVVLTSHSMEECEALCTRMAIMVNGR 2172

  Fly  1469 FKCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGTLKSEFPGLELRESHAGTLTYFVSTQ 1531
            ||||.::..||..  .|:||.:::..   :..::..:.......|||..|:|.|...|.|.:.:.
Frog  2173 FKCLGSVQHLKNRFGDGYTIIVRIAG---SNPDLKPVEEFFSHAFPGSVLKEKHRSMLQYQLRSS 2234

  Fly  1532 ESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQSTSRQ 1585
            :|.:  :.:|.|..:   ::....:.||||::.||:.:|:.|   ||.||...|
Frog  2235 QSSL--ARIFSILSK---NKKRLHIEDYSVSQTTLDQVFVNF---AKDQSDDDQ 2280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	38/146 (26%)
		CcmA	460..767	CDD:224054	110/414 (27%)
		ABC_subfamily_A	461..679	CDD:213230	81/233 (35%)
		ABC2_membrane_3	<937..1117	CDD:289468	47/252 (19%)
		ABC_subfamily_A	1255..1479	CDD:213230	104/226 (46%)
		drrA	1262..1573	CDD:130256	125/315 (40%)
abca1	XP_004910916.1	rim_protein	1..2272	CDD:130324	470/1994 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010