Protein Alignment Eato and abca2

DIOPT Version :9

• Sequence 1: NP_001036360.1
• Gene: Eato / 34783
• FlyBaseID: FBgn0028539
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: XP_005165286.1
• Gene: abca2 / 100006090
• ZFINID: ZDB-GENE-050517-1
• Length: 2504
• Species: Danio rerio
• Alignment Length: 1837
• Identity: 475/1837 - (25%)
• Similarity: 775/1837 - (42%)
• Gaps: 513/1837 - (27%)

  Fly   174 YIRSGFLSLQHILDKQYMKYQELGKDFEVVVSSMPNMEVISMDSH----------------RLTY 222
            |...||:.:|.::::             .::::....:|:...::                .:.:
Zfish   708 YFLYGFVWIQDMIER-------------AIINTFVGHDVVEPGNYVQMFPYPCYTRDDFLFVIEH 759

  Fly   223 FGTLCSILFNVVLLSSFVVPFVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYTLLMIFVLVV 287
            ...||.::..|..::..:...|.||:..|||.:.::...:.::.:.:|:..||   .|.|.|..:
Zfish   760 MMPLCMVISWVYSVAMMIQHIVAEKEQRLKEVMKMMGLNNAVHWVAWFITGFV---QLSISVTAL 821

  Fly   288 AYLYKALGSICF---AYVAVLFL-LYILSTMSYAYLISICFHSVFYAK-IGGLAMLI--IPYAFS 345
            ..:.| .|.:..   .::..||| :|.::|:.:.:|:|:.:.....|. .||:...:  :||.:.
Zfish   822 TAILK-YGKVLLHSDPFIIWLFLTIYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYV 885

  Fly   346 FVRSWATSLAFVCF--------STNTFLEGLDIFQTFSNKRKNREFGAVDVFRVIKSNSSTMFSV 402
            .:|..........|        ||..|..|...|..:.......::..::...|...:.:.:.|:
Zfish   886 AIREEVAHDKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWRTINQSPVEGDDFNLLLSM 950

  Fly   403 YVVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTY------------------------ 443
             |:|...:.:|.:|..|:..|.||..||.||.:|.|. |:|
Zfish   951 -VMLTIDAIVYGVLTWYIEAVHPGMYGLPRPWYFPLQ-KSYWLGSGRIETWEWPWGGGTRLSVME 1013

  Fly   444 ------MKRQRNEYTTTPRGTH--------AIIITELCKKFQTSKRDTLISDNLNMTINNKEITV 494
                  |:.:|:|.|   ||..        .:.|.:|.|.::|..:  |..:.|::.::..::..
Zfish  1014 EDQACAMEHRRSEET---RGIEEEPNHLPLVVCIDKLTKVYKTGSK--LALNKLSLNLHENQVVS 1073

  Fly   495 LLGHNGAGKTTMMNMIMGLVPKDSGKIIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLE 556
            .||||||||||.|:::.||.|..||...:..   ..::...|..:|.||||:|....::..:||.
Zfish  1074 FLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMERIRQNLGMCPQHNVLFDKLSVEEHLW 1138

  Fly   557 FFAQLRGACRSDARDWADEKLKKLGLSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSS 621
            |:::|:|....|.|...|:.::.|.||:||:...:.|||||||:||:.||..|.::.||||||::
Zfish  1139 FYSRLKGMAEEDIRKEMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAVILDEPTA 1203

  Fly   622 GLDINSRRELWDILLNLRKEKAVLVTTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGY 686
            |:|..:||.:||::|..::.:.:|::||:|:||::|||.|.|:::|||:..||||.||...|.||
Zfish  1204 GVDPYARRAIWDLILKYKQGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKSTYGDGY 1268

  Fly   687 RLKL-------EINDFTSR----------EVEIMEIIHHFVPTARVLNVVNPTVYICLP--YAYK 732
            :|.|       ...|.:|:          |..:.:.|..:|.:..:::..|..:...||  ...|
Zfish  1269 KLTLVKKQSDSHTADQSSQSPSSSISPCSENRVTQFIRQYVASCLLVSDSNTELSYVLPSEAVKK 1333

  Fly   733 NCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGEQ--------DQVDTPDGS-------- 781
            .||.::...||.....|.:.:..:.||:||:|||:.:.|.        |..|:|.|:
Zfish  1334 GCFERLFQALEQSLDSLALTSFGVMDTTLEEVFLKVSEEDLSLENSDADMKDSPGGASAGKPSGL 1398

  Fly   782 ----------------------------------------------RND------------APLL 788
                                                          |.|            .||.
Zfish  1399 LGGPQCEGAPAAAVMRPEVELSNLMMCSRLSPSQASLQSGSSLGSVRGDEGGPYSEFYGDYCPLF 1463

  Fly   789 AHYKRL-------QDHPPH------RGLFQL---WM------AVFYKKWTFI--SNEWLYTLIML 829
            .:.:.|       ::..|.      :|.|:|   |:      .:..|::...  :.:.:::.|:|
Zfish  1464 DNGQDLDSASLRDEESSPQPTVLEGQGSFKLDGWWLKLRQFHGLIVKRFHCAKRNTKGIFSQILL 1528

  Fly   830 CIPFVCVFGAILVMHAMSLVENEEALPLKLS---------QMGSGVIYVHN-------------- 871
            ...||||  |:.|  |:|:.|..:..||.||         ..|:.:.|.:.
Zfish  1529 PAFFVCV--AMTV--ALSVPEIGDLPPLILSPSQYHNYTQPRGNFIPYANEDRSQYRTKFSPDAG 1589

  Fly   872 ----------PTG----------HHAHLEQQLRQQIELNGITAKTMHLRGSNDVKNESLDLQRDN 916
                      |:|          .::.|: ||.|.:......:||:..|..:.:..:|. .|...
Zfish  1590 PQRIVNTLRLPSGVGATCILKTPFNSTLD-QLAQTLNPYANNSKTLAARYFDSMCLDSF-TQGVP 1652

  Fly   917 LADFL---------------------------------------------EQVIGIIDMYG---- 932
            |::|:                                             |.|..|..|.|
Zfish  1653 LSNFVPPPPSPAPSDDPEAHFEDGLWNYTAAPTTVREMATSPPTLPLSIHEPVRCICSMQGTGFS 1717

  Fly   933 -----GGRG-------------------------TSD--------------------------TP 941
                 |||.                         |||                          ||
Zfish  1718 CPSGVGGRPPLMKVVTGDILVDITGRNVSEYLLYTSDRLRLHRYGGFTVGNIQKSVPASFGRKTP 1782

  Fly   942 TI----------EIFYSGNRYHSSVELINLVDSAMLKLGRPESE-------IDTTYVPIRRFVSD 989
            .:          ::.|:...|||....:|::::|:|:...|.|:       |..|..|:.|..:.
Zfish  1783 PMVRKIAVRRSSQVLYNNKGYHSMPTYLNVLNNAILRANLPSSKGNPSAYGITVTNHPMNRTSAS 1847

  Fly   990 ISPSRLEY--------YAVIVPIGMFFFMFYFISLPFREYANGFKQLQTMS---RFTYWFAHFTF 1043
            :|   |:|        .|:.:.:.|.|....|:.....|.:...|.||.:|   ..|||.|::.:
Zfish  1848 LS---LDYLLQGTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCDPVTYWLANYIW 1909

  Fly  1044 DML----------ILIFVCVALFSLQSLMMPSELYTTAELKVIVLSIF-FYGCSYLPILYALGNN 1097
            |||          :::||    |.|.:       ||:......|||:| .||.|..||:|.....
Zfish  1910 DMLNYLVPATCCVLILFV----FDLPA-------YTSPTNFPAVLSLFLLYGWSITPIMYPASFW 1963

  Fly  1098 FKSISTISTYLLLM-LIVSAIAPLITSSNAAAMKLHE-----------TKIAFLCFLPDFNLNHQ 1150
            |:..||...:|::: |.:...|.:.|    ..::|.|           .|..||.| |::||.|.
Zfish  1964 FEVPSTAYVFLIVINLFIGITATVAT----FLLQLFERDKDLKLVNSYLKSCFLIF-PNYNLGHG 2023

  Fly  1151 F------RIINE------NFITRRHP----ALIKGLISQDTFFAYATAVGVMVMAFFTIVLEHKY 1199
            .      ..|||      .|...:.|    .:.:||::. |...:   ||.::    ||:.::.:
Zfish  2024 LMEMAYNEYINEYYAKIGQFDKVKSPFEWDIVTRGLVAM-TIEGF---VGFLI----TILCQYNF 2080

  Fly  1200 LRRRIHDGIWEWAFQRKKYNSTGTLPSTPISEID-DCAREEKRVTDLIKDPLNDHSLIVHNLRKR 1263
            ||:.          ||...|      |.|:.:.| |.|.|.:||  |..|..|| .|.:.||.|.
Zfish  2081 LRKA----------QRVPVN------SQPVEDDDVDVACERRRV--LRGDADND-MLKIDNLTKV 2126

  Fly  1264 Y-----GDKLAVDGVSFAAAQGECFGLLGVNGAGKTSTFQMIAANLPLDGGTIRIKGADIREHEL 1323
            |     |..||||.:......|||||||||||||||:||:|:..:....||...|:...|....|
Zfish  2127 YKSRKMGRILAVDRLCLGVRPGECFGLLGVNGAGKTTTFKMLTGDESTTGGEAFIQEHSILRELL 2191

  Fly  1324 KYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRRRTDGPASCKEHVKYW-LEKMHLTKYQKV 1387
            :.::..|||||:|||...:||.:.|.....|||:       |...:|.|..| |||:.|:||...
Zfish  2192 RVQQSIGYCPQFDALFDDLTAREHLELYTRLRGI-------PWKDEERVVQWALEKLELSKYADK 2249

  Fly  1388 QVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPISRRFLWQCIKDFQGKDRTVVLTSHSMD 1452
            ....||||.||||..|:|:||.|:|:.|||||||:||.:|||||..|.|.....|:||||||||:
Zfish  2250 PAGTYSGGNKRKLSTAIALIGYPSLIFLDEPTTGMDPKARRFLWNLILDIIKTGRSVVLTSHSME 2314

  Fly  1453 ECEELCNRLAIMAHGKFKCLNNICALKRL--SGFTIKLKMKADTETEMNVSTITGTLKSEFPGLE 1515
            |||.||.||.||.:|:||||.:|..||..  .|:.|.::    |:|..:|..:.......||...
Zfish  2315 ECEALCTRLGIMVNGRFKCLGSIQHLKNRFGDGYMITVR----TKTTASVKEVIRFFNRNFPEAI 2375

  Fly  1516 LRESHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKF------- 1573
            |:|.|...:.|.:.: |::.| :.||...|:.: :.||  :.||||::.||:::|:.|
Zfish  2376 LKERHHTKIQYQLKS-ENISL-AQVFSKMEQVV-EVLS--IEDYSVSQTTLDNVFVNFAKKQSDN 2435

  Fly  1574 -EREAKSQSTSRQTSVQ 1589
             |::..|.|:..|:.:|
Zfish  2436 LEQQESSPSSGGQSPLQ 2452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	30/160 (19%)
		CcmA	460..767	CDD:224054	112/328 (34%)
		ABC_subfamily_A	461..679	CDD:213230	85/220 (39%)
		ABC2_membrane_3	<937..1117	CDD:289468	58/245 (24%)
		ABC_subfamily_A	1255..1479	CDD:213230	111/229 (48%)
		drrA	1262..1573	CDD:130256	135/318 (42%)
abca2	XP_005165286.1	rim_protein	1..2435	CDD:130324	470/1818 (26%)
		ABC_subfamily_A	1042..1261	CDD:213230	85/220 (39%)
		ABC_subfamily_A	2118..2341	CDD:213230	111/229 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582266
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940