DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38b and Mapk14

DIOPT Version :9

Sequence 1:	NP_477361.1	Gene:	p38b / 34780	FlyBaseID:	FBgn0024846	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_112282.2	Gene:	Mapk14 / 81649	RGDID:	70496	Length:	360	Species:	Rattus norvegicus

Alignment Length:	353	Identity:	245/353 - (69%)
Similarity:	287/353 - (81%)	Gaps:	3/353 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRKMAKFYKLDINRTEWEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHA 65
            ||::...||:.::|:|.||:||.||||.|||.||||.||.|....|..:||:|||:|||||.:||
  Rat     1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHA 65

  Fly    66 KRTYRELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQKLSDDHV 130
            |||||||||||||.|||||||||||   .||.||::|..||:|||||.||||||::.|||:||||
  Rat    66 KRTYRELRLLKHMKHENVIGLLDVF---TPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 127

  Fly   131 QFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESEMTGYVATRWYRAPE 195
            |||:|||||||||||||.:|||||||||:||||||||:||||||||..:.|||||||||||||||
  Rat   128 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPE 192

  Fly   196 IMLNWMHYNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARN 260
            |||||||||||.|||||||||||||||||||||||||:||..||.:.|||....::|:.|..|||
  Rat   193 IMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYLINRMPSHEARN 257

  Fly   261 YIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHDPTDEQTAAL 325
            ||:||..||:.||.::|.||||||:|||||||.||:||||||.|||||.|..:||||.||..|..
  Rat   258 YIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADP 322

  Fly   326 YDQSFEENELPVEKWREMVFSEVTAFKP 353
            ||||||..:|.:::|:.:.:.||.:|.|
  Rat   323 YDQSFESRDLLIDEWKSLTYDEVISFVP 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	242/344 (70%)
p38b	NP_477361.1	S_TKc	24..311	CDD:214567	215/286 (75%)
Mapk14	NP_112282.2	STKc_p38alpha	6..350	CDD:143382	242/346 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340475
Domainoid	1	1.000	453	1.000	Domainoid score	I483
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31777
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1213
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	1	1.000	-	-		mtm8969
orthoMCL	1	0.900	-	-		OOG6_102675
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760