DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p38b and Mapk11

DIOPT Version :9

Sequence 1:	NP_477361.1	Gene:	p38b / 34780	FlyBaseID:	FBgn0024846	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	XP_017450608.1	Gene:	Mapk11 / 689314	RGDID:	1309340	Length:	371	Species:	Rattus norvegicus

Alignment Length:	360	Identity:	233/360 - (64%)
Similarity:	283/360 - (78%)	Gaps:	10/360 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRKMAKFYKLDINRTEWEIPETYQNLQPVGQGAYGQVC-------KAVVRGTSTKVAIKKLARP 58
            ||...|.||:.::|:|.||:|:..|.|:|||.||||.|.       .|.......|||:|||:||
  Rat     1 MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVWSHPGPPHSAYDARLRQKVAVKKLSRP 65

  Fly    59 FQSAVHAKRTYRELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQ 123
            |||.:||:|||||||||||:.|||||||||||   .||.|::.|.:||:||.||.||||||::.|
  Rat    66 FQSLIHARRTYRELRLLKHLKHENVIGLLDVF---TPATSIEDFSEVYLVTTLMGADLNNIVKCQ 127

  Fly   124 KLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESEMTGYVAT 188
            .|||:||||||||:|||||||||||:|||||||||:|||||||||||||||||.|:.||||||||
  Rat   128 ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVAT 192

  Fly   189 RWYRAPEIMLNWMHYNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRI 253
            ||||||||||||||||||.|||||||||||||.|:.||||.|:|.||..||||:|||:.|.:::|
  Rat   193 RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKI 257

  Fly   254 SSESARNYIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHDPT 318
            |||.||.||:|||.||:::...:|.||||||:|||.:||.||:|:|::|.:||||.|..:||||.
  Rat   258 SSEHARTYIQSLPPMPQKDLSSVFHGANPLAVDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPD 322

  Fly   319 DEQTAALYDQSFEENELPVEKWREMVFSEVTAFKP 353
            ||..|..||:|.|..|..:|:|:|:.:.||.:|||
  Rat   323 DEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKP 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	228/351 (65%)
p38b	NP_477361.1	S_TKc	24..311	CDD:214567	202/293 (69%)
Mapk11	XP_017450608.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11147
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1213
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	1	1.000	-	-		mtm8969
orthoMCL	1	0.900	-	-		OOG6_102675
Panther	1	1.100	-	-	LDO	PTHR24055
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870