DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38b and mapk14a

DIOPT Version :9

Sequence 1:	NP_477361.1	Gene:	p38b / 34780	FlyBaseID:	FBgn0024846	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_571797.1	Gene:	mapk14a / 65237	ZFINID:	ZDB-GENE-010202-2	Length:	361	Species:	Danio rerio

Alignment Length:	354	Identity:	247/354 - (69%)
Similarity:	283/354 - (79%)	Gaps:	4/354 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRK-MAKFYKLDINRTEWEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVH 64
            ||:| ...||:.::|:|.||:|..||||.|||.||||.||.|....|..|||:|||:|||||.:|
Zfish     1 MSQKERPTFYRQEVNKTIWEVPVQYQNLSPVGSGAYGSVCSAFDAKTGFKVAVKKLSRPFQSIIH 65

  Fly    65 AKRTYRELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQKLSDDH 129
            ||||||||||||||.|||||||||||   .||.||.:|..||:|||||.||||||::.|||:|||
Zfish    66 AKRTYRELRLLKHMRHENVIGLLDVF---TPATSLKEFNDVYLVTHLMGADLNNIVKCQKLTDDH 127

  Fly   130 VQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESEMTGYVATRWYRAP 194
            ||||:|||||||||||||.:|||||||||:||||||||:||||||||..:.||||||||||||||
Zfish   128 VQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAP 192

  Fly   195 EIMLNWMHYNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESAR 259
            ||||||||||.|.|||||||||||||||||||||||||:||..||.:.|||....:||:.|..||
Zfish   193 EIMLNWMHYNVTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPSSLISRMPSHEAR 257

  Fly   260 NYIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHDPTDEQTAA 324
            .||.|||.||:|||.|:|.||||.|:|||||||.||.||||||.:||||||..:||||.||..|.
Zfish   258 TYISSLPQMPKRNFADVFIGANPQAVDLLEKMLVLDTDKRITAAEALAHPYFAQYHDPDDEPEAE 322

  Fly   325 LYDQSFEENELPVEKWREMVFSEVTAFKP 353
            .:|||||..||.:|:|:...:.|:.:|:|
Zfish   323 PFDQSFESRELDIEEWKRQTYEEMISFEP 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	243/344 (71%)
p38b	NP_477361.1	S_TKc	24..311	CDD:214567	217/286 (76%)
mapk14a	NP_571797.1	STKc_p38alpha	7..351	CDD:143382	243/346 (70%)
		S_TKc	25..309	CDD:214567	217/286 (76%)
		TXY	181..183		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580267
Domainoid	1	1.000	447	1.000	Domainoid score	I500
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31777
Inparanoid	1	1.050	512	1.000	Inparanoid score	I1274
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	1	1.000	-	-		mtm6418
orthoMCL	1	0.900	-	-		OOG6_102675
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R566
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790