DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38b and Mapk6

DIOPT Version :9

Sequence 1:	NP_477361.1	Gene:	p38b / 34780	FlyBaseID:	FBgn0024846	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_113810.2	Gene:	Mapk6 / 58840	RGDID:	62087	Length:	720	Species:	Rattus norvegicus

Alignment Length:	374	Identity:	130/374 - (34%)
Similarity:	206/374 - (55%)	Gaps:	46/374 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MAKFYKLDINRTEWEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKK--LARPFQSAVHAKR 67
            ||:.::..:|...:::...|.:|:|:|.|..|.|..||......:|||||  |..| ||..||
  Rat     1 MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QSVKHA-- 62

  Fly    68 TYRELRLLKHMDHENVIGLLDVFHP--GQPAD---SLDQFQQVYMVTHLMDADLNNIIRTQKLSD 127
             .||:::::.:||:|::.:.::..|  .|..|   ||.:...||:|...|:.||.|::....|.:
  Rat    63 -LREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLE 126

  Fly   128 DHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVN-EDCELRILDFGLARPAESEMT--GYVA-- 187
            :|.:..:||:||||||||||.|:||||||:|:.:| ||..|:|.||||||..:...:  |:::
  Rat   127 EHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191

  Fly   188 --TRWYRAPEIMLNWMHYNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFM 250
              |:|||:|.::|:..:|.:..|:|:.|||.||:|||:|||.|...:.|:.||:|.:....:|..
  Rat   192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDR 256

  Fly   251 SRISSESARNYIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYH 315
            ..:.| ....|||:....|.:....:..|.:..|:|.||::|......|:|||:||:||||..|.
  Rat   257 QELLS-VIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYS 320

  Fly   316 DPTDEQTAA---------------------------LYDQSFEENELPV 337
            .||||..::                           .:|..|.|::.|:
  Rat   321 FPTDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPI 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	128/371 (35%)
p38b	NP_477361.1	S_TKc	24..311	CDD:214567	116/300 (39%)
Mapk6	NP_113810.2	STKc_MAPK4_6	14..355	CDD:143359	123/345 (36%)
		S_TKc	20..316	CDD:214567	116/300 (39%)
		SEG motif	189..191		0/1 (0%)
		FRIEDE motif	332..337		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..657
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	698..720
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810