DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38b and MAPK6

DIOPT Version :9

Sequence 1:	NP_477361.1	Gene:	p38b / 34780	FlyBaseID:	FBgn0024846	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_002739.1	Gene:	MAPK6 / 5597	HGNCID:	6879	Length:	721	Species:	Homo sapiens

Alignment Length:	374	Identity:	130/374 - (34%)
Similarity:	205/374 - (54%)	Gaps:	46/374 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MAKFYKLDINRTEWEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKK--LARPFQSAVHAKR 67
            ||:.::..:|...:::...|.:|:|:|.|..|.|..||......:|||||  |..| ||..||
Human     1 MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDP-QSVKHA-- 62

  Fly    68 TYRELRLLKHMDHENVIGLLDVFHP--GQPAD---SLDQFQQVYMVTHLMDADLNNIIRTQKLSD 127
             .||:::::.:||:|::.:.::..|  .|..|   ||.:...||:|...|:.||.|::....|.:
Human    63 -LREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLE 126

  Fly   128 DHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVN-EDCELRILDFGLARPAESEMT--GYVA-- 187
            :|.:..:||:||||||||||.|:||||||:|:.:| ||..|:|.||||||..:...:  |:::
Human   127 EHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEG 191

  Fly   188 --TRWYRAPEIMLNWMHYNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFM 250
              |:|||:|.::|:..:|.:..|:|:.|||.||:|||:|||.|...:.|:.||:|.:....:|..
Human   192 LVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDR 256

  Fly   251 SRISSESARNYIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYH 315
            ..:.| ....|||:....|.:....:..|.:..|:|.||::|......|:|||:||:||||..|.
Human   257 QELLS-VIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYS 320

  Fly   316 DPTDEQTAA---------------------------LYDQSFEENELPV 337
            .|.||..::                           .:|..|.|::.||
Human   321 FPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPV 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	128/371 (35%)
p38b	NP_477361.1	S_TKc	24..311	CDD:214567	116/300 (39%)
MAPK6	NP_002739.1	STKc_MAPK4_6	14..355	CDD:143359	122/345 (35%)
		SEG motif	189..191		0/1 (0%)
		FRIEDE motif	332..337		0/4 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810