DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38b and mapk12

DIOPT Version :9

Sequence 1:	NP_477361.1	Gene:	p38b / 34780	FlyBaseID:	FBgn0024846	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_001017080.1	Gene:	mapk12 / 549834	XenbaseID:	XB-GENE-485782	Length:	363	Species:	Xenopus tropicalis

Alignment Length:	349	Identity:	214/349 - (61%)
Similarity:	267/349 - (76%)	Gaps:	3/349 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FYKLDINRTEWEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYREL 72
            :|:.|:|:|.||:.|.|::|..||.||||.||.::...|.||||||||.|||||.:.|||.||||
Frog    11 YYRQDVNKTVWEVKERYRDLVAVGSGAYGTVCSSLDTRTGTKVAIKKLYRPFQSELFAKRAYREL 75

  Fly    73 RLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQKLSDDHVQFLVYQI 137
            ||||||.|||||||||||   .|..:|:.|...|:|...|..||..|::.:|||:|.:|||||||
Frog    76 RLLKHMQHENVIGLLDVF---TPDSTLENFNDFYLVMPFMGTDLGKIMKHEKLSEDRIQFLVYQI 137

  Fly   138 LRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESEMTGYVATRWYRAPEIMLNWMH 202
            |||||||||||:|||||||.|:||||||||:||||||||..:|||||||.||||||||::|||||
Frog   138 LRGLKYIHSAGIIHRDLKPGNLAVNEDCELKILDFGLARHTDSEMTGYVVTRWYRAPEVILNWMH 202

  Fly   203 YNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPV 267
            |.||.|||||||||||:.|||.||.|.||:.||..||::.|||..:|:.::.|..|:|||:|||.
Frog   203 YTQTVDIWSVGCIMAEMYTGRPLFKGNDHLDQLTEIMKITGTPTQDFVQKLQSPDAKNYIKSLPK 267

  Fly   268 MPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHDPTDEQTAALYDQSFEE 332
            :.:::|..:.|.|||||:::|||||.|||:|||||.:||||||.|::||..||..|..||.||:.
Frog   268 VQKKDFGSLLRYANPLAVNILEKMLVLDAEKRITATEALAHPYFEQFHDIDDETEAEPYDDSFDN 332

  Fly   333 NELPVEKWREMVFSEVTAFKPTAA 356
            ..||:|:||.:...|:|::||..|
Frog   333 VNLPLEEWRRLTHKELTSYKPLVA 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	211/344 (61%)
p38b	NP_477361.1	S_TKc	24..311	CDD:214567	186/286 (65%)
mapk12	NP_001017080.1	STKc_p38gamma	11..353	CDD:143385	211/344 (61%)
mapk12	NP_001017080.1	S_TKc	27..311	CDD:214567	186/286 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11260
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010