DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38b and Mapk12

DIOPT Version :9

Sequence 1:	NP_477361.1	Gene:	p38b / 34780	FlyBaseID:	FBgn0024846	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	XP_006521121.1	Gene:	Mapk12 / 29857	MGIID:	1353438	Length:	390	Species:	Mus musculus

Alignment Length:	380	Identity:	205/380 - (53%)
Similarity:	262/380 - (68%)	Gaps:	26/380 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FYKLDINRTEWEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYREL 72
            ||:.::.:|.||:...||:|||||.||||.||.||...|..|||||||.|||||.:.|||.||||
Mouse    11 FYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGNKVAIKKLYRPFQSELFAKRAYREL 75

  Fly    73 RLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQKLSDDHVQFLVYQI 137
            ||||||.|||||||||||   .|.:|||.|...|:|...|..||..:::.:.||:|.:||||||:
Mouse    76 RLLKHMRHENVIGLLDVF---TPDESLDDFTDFYLVMPFMGTDLGKLMKHETLSEDRIQFLVYQM 137

  Fly   138 LRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESEMTGYVATRWYRAPEIMLNWMH 202
            |:||||||:||||||||||.|:||||||||:||||||||.|:|||||||.||||||||::||||.
Mouse   138 LKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMR 202

  Fly   203 YNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISS------------ 255
            |.||.|||||||||||::||:.||.|.||:.||..||::.|||..||:.::.|
Mouse   203 YTQTVDIWSVGCIMAEMITGKILFKGNDHLDQLKEIMKITGTPPPEFVQKLQSAEVSGSGWWAGL 267

  Fly   256 -----------ESARNYIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHP 309
                       ..|:||:..||.:.:::|..:...|:|.|::|||:||.|||::|:||.:||.||
Mouse   268 GLGGWPITLFPSQAKNYMEGLPELEKKDFASVLTNASPQAVNLLERMLVLDAEQRVTAAEALTHP 332

  Fly   310 YMEKYHDPTDEQTAALYDQSFEENELPVEKWREMVFSEVTAFKPTAAFAELLPKE 364
            |.|...|..||..|..||.||::.:..:|:|:.:.:.||.:|||.......:|||
Mouse   333 YFESLRDTEDEPKAQKYDDSFDDVDRTLEEWKRVTYKEVLSFKPPRQLGARVPKE 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	200/367 (54%)
p38b	NP_477361.1	S_TKc	24..311	CDD:214567	180/309 (58%)
Mapk12	XP_006521121.1	STKc_p38gamma	11..376	CDD:143385	200/367 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11281
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.870