DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38b and mapk14b

DIOPT Version :9

Sequence 1:	NP_477361.1	Gene:	p38b / 34780	FlyBaseID:	FBgn0024846	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_001300688.1	Gene:	mapk14b / 266756	ZFINID:	ZDB-GENE-021007-1	Length:	361	Species:	Danio rerio

Alignment Length:	354	Identity:	253/354 - (71%)
Similarity:	290/354 - (81%)	Gaps:	4/354 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRK-MAKFYKLDINRTEWEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVH 64
            ||:| ...||:.::|:|.||:||.||||.|||.||||.||.|.......:||:|||:|||||.:|
Zfish     1 MSQKARPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCSAFDGKAGLRVAVKKLSRPFQSIIH 65

  Fly    65 AKRTYRELRLLKHMDHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQKLSDDH 129
            ||||||||||||||.|||||||||||   .||.||::|..||:|||||.||||||::.|||:|||
Zfish    66 AKRTYRELRLLKHMKHENVIGLLDVF---SPATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDH 127

  Fly   130 VQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESEMTGYVATRWYRAP 194
            ||||:|||||.|||||||.:|||||||||:||||||||:||||||||..:.||||||||||||||
Zfish   128 VQFLIYQILRALKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARLTDDEMTGYVATRWYRAP 192

  Fly   195 EIMLNWMHYNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESAR 259
            ||||||||||.|.|||||||||||||||||||||||||.||.|||.::|||..|.:.:|||||||
Zfish   193 EIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLIMMLVGTPGPELLMKISSESAR 257

  Fly   260 NYIRSLPVMPRRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHDPTDEQTAA 324
            |||.|||.||:|||.|:|.||||||:|||||||.||.||||||.|||||||..:||||.||..|.
Zfish   258 NYISSLPHMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASQALAHPYFAQYHDPDDEPEAD 322

  Fly   325 LYDQSFEENELPVEKWREMVFSEVTAFKP 353
            .||||||..:|.:|:|:.:.:.||.:|:|
Zfish   323 PYDQSFESRDLEIEEWKSLTYEEVMSFEP 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	249/344 (72%)
p38b	NP_477361.1	S_TKc	24..311	CDD:214567	221/286 (77%)
mapk14b	NP_001300688.1	PKc_like	7..351	CDD:304357	249/346 (72%)
mapk14b	NP_001300688.1	S_TKc	25..309	CDD:214567	221/286 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580266
Domainoid	1	1.000	447	1.000	Domainoid score	I500
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	512	1.000	Inparanoid score	I1274
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D324618at33208
OrthoFinder	1	1.000	-	-		FOG0000533
OrthoInspector	1	1.000	-	-		mtm6418
orthoMCL	1	0.900	-	-		OOG6_102675
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R566
SonicParanoid	1	1.000	-	-		X352
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790