DRSC/TRiP Functional Genomics Resources

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Protein Alignment p38b and Mapk4

DIOPT Version :9

Sequence 1:NP_477361.1 Gene:p38b / 34780 FlyBaseID:FBgn0024846 Length:365 Species:Drosophila melanogaster
Sequence 2:NP_766220.2 Gene:Mapk4 / 225724 MGIID:2444559 Length:583 Species:Mus musculus


Alignment Length:325 Identity:117/325 - (36%)
Similarity:182/325 - (56%) Gaps:33/325 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 WEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMDHEN 82
            :::...:.:.||:|.|..|.|..|.......|||:||:.  ...|...|...||:::::.:||:|
Mouse    14 YDLGGRFIDFQPLGFGVNGLVLSATDSRACRKVAVKKIV--LSDARSMKHALREIKIIRRLDHDN 76

  Fly    83 VIGLLDVFHPGQPAD---SLDQFQQVYMVTHLMDADLNNIIRTQKLSDDHVQFLVYQILRGLKYI 144
            ::.:.:|..| :.:|   .|.:|...|:|...|:.||..::....|::||.:..:||:|||||||
Mouse    77 IVKVYEVLGP-KGSDLQGELFKFSVAYIVQEYMETDLACLLEQGTLTEDHAKLFMYQLLRGLKYI 140

  Fly   145 HSAGVIHRDLKPSNIAVN-EDCELRILDFGLARPAESEMT--GYVA----TRWYRAPEIMLNWMH 202
            |||.|:||||||:||.:: ||..|:|.||||||..:...:  ||::    |:|||:|.::|:..:
Mouse   141 HSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNN 205

  Fly   203 YNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPV 267
            |.:..|:|:.|||:||:|||:.||.|...:.|:.||::.:....:|....:           |.|
Mouse   206 YTKAIDMWAAGCILAEMLTGKMLFAGAHELEQMQLILDTIPVVREEDKEEL-----------LRV 259

  Fly   268 MP---------RRNFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHDPTDEQTA 323
            ||         :|..|.:....|..|||.|||:|..:...|:|||..|.||||..|..|.||.|:
Mouse   260 MPSFVSSTWEVKRPLRKLLPDVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTS 324

  Fly   324  323
            Mouse   325  324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
p38bNP_477361.1 STKc_p38 8..353 CDD:143356 117/325 (36%)
S_TKc 24..311 CDD:214567 110/305 (36%)
Mapk4NP_766220.2 STKc_MAPK4_6 14..351 CDD:143359 117/325 (36%)
SEG motif 186..188 0/1 (0%)
FRIEDE motif 328..333
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 366..410
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 495..531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0660
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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