DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p38b and Mapk7

DIOPT Version :9

Sequence 1:	NP_477361.1	Gene:	p38b / 34780	FlyBaseID:	FBgn0024846	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_001178476.1	Gene:	Mapk7 / 114509	RGDID:	621505	Length:	812	Species:	Rattus norvegicus

Alignment Length:	345	Identity:	162/345 - (46%)
Similarity:	229/345 - (66%)	Gaps:	16/345 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 WEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKHMDHEN 82
            :::.:.|:.::.:|.||||.|..|..|.|..:|||||:...|....:||||.|||::|||..|:|
  Rat    49 FDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDN 113

  Fly    83 VIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIR-TQKLSDDHVQFLVYQILRGLKYIHS 146
            :|.:.|:..|..|   ..:|:.||:|..||::||:.||. :|.|:.:||::.:||:||||||:||
  Rat   114 IIAIKDILRPTVP---YGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHS 175

  Fly   147 AGVIHRDLKPSNIAVNEDCELRILDFGLAR-----PAESE--MTGYVATRWYRAPEIMLNWMHYN 204
            |.||||||||||:.|||:|||:|.|||:||     |||.:  ||.|||||||||||:||:...|.
  Rat   176 AQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT 240

  Fly   205 QTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPADEFMSRISSESARNYIRSLPVMP 269
            |..|:||||||..|:|..|.||||.:::|||.|||.|||||:...:..:.:|..|.||:|||  |
  Rat   241 QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLP--P 303

  Fly   270 RR--NFRDIFRGANPLAIDLLEKMLELDADKRITAEQALAHPYMEKYHDPTDE-QTAALYDQSFE 331
            |:  .:..::.||:..|:.||.:||..:...||:|..||.||::.|||||.|| ..|..:|.:|:
  Rat   304 RQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFD 368

  Fly   332 ENELPVEKWREMVFSEVTAF 351
            ...|..|:.:|.:.:|:..|
  Rat   369 REALTRERIKEAIVAEIEDF 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p38b	NP_477361.1	STKc_p38	8..353	CDD:143356	162/345 (47%)
p38b	NP_477361.1	S_TKc	24..311	CDD:214567	147/296 (50%)
Mapk7	NP_001178476.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for cytoplasmic targeting. /evidence=ECO:0000250	2..77		9/27 (33%)
		STKc_ERK5	49..384	CDD:270842	160/339 (47%)
		Required for binding to MAP2K5. /evidence=ECO:0000250	78..139		26/63 (41%)
		Necessary for oligomerization. /evidence=ECO:0000250	140..406		125/251 (50%)
		TXY. /evidence=ECO:0000250	219..221		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..475
		Nuclear localization signal. /evidence=ECO:0000250	505..539
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810