DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TM9SF4 and Tm9sf4

DIOPT Version :9

Sequence 1:	NP_001285907.1	Gene:	TM9SF4 / 34778	FlyBaseID:	FBgn0028541	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_006500539.1	Gene:	Tm9sf4 / 99237	MGIID:	2139220	Length:	644	Species:	Mus musculus

Alignment Length:	634	Identity:	408/634 - (64%)
Similarity:	497/634 - (78%)	Gaps:	19/634 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VLLAGVVLVADSFYVPGVAPVEFVQDQKIDVKAVKMTSSRTQLPYQYYSLRFCYPKNGTLIFKSE 78
            :||..:.....:||||||||:.|.|:..:::||||:|||||||||:||||.||.|..  :.:|:|
Mouse    13 LLLLCLTCKGSTFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPIK--ITYKAE 75

  Fly    79 NLGEVLRGDRIVNTPYEVRMNQQVNCRLLCNQKDRPLTWSKEDSALVAERIQHEYFVHLLVDNLP 143
            |||||||||||||||::|.||.:..|.:||||.::|:|.:.|.|.||||||..||:|||:.||||
Mouse    76 NLGEVLRGDRIVNTPFQVLMNSEKKCEVLCNQSNKPITLTVEQSRLVAERITEEYYVHLIADNLP 140

  Fly   144 VATR--IVSVNNPA-------EVTYEHGYRLGQVDGDNIYINNHLKFILSYHMHSKDK-----YR 194
            ||||  :.|.|..:       :|.:|||||||..|.:.||::|||.|||.||....::     ||
Mouse   141 VATRLELYSSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYR 205

  Fly   195 VVGFEVETVSVSHKELKF-HGDTCNFPDSAR--PQLVNPNGETQLYFTYSVEWKESKVSWASRWD 256
            ||.|||...|:..::||. ...:|..|:.|.  ||.::|..|.||||||||.|:||.:.||||||
Mouse   206 VVRFEVIPQSIRLEDLKTGEKSSCTLPEGANSLPQEIDPTKENQLYFTYSVHWEESDIKWASRWD 270

  Fly   257 IYLGMRDVQIHWFSIINSLVVVFFLSGILTMIMIRTLRRDIARYNTDDNIEDTLEETGWKLVHGD 321
            .||.|.||||||||||||:||||||||||:||:|||||:|||.||.:|:||||:||:||||||||
Mouse   271 TYLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGD 335

  Fly   322 VFRPPKNTRLFSAIIGSGIQIFFMALITIFFAMLGMLSPSSRGALMTSGIFMYVFMGTIAGYYAA 386
            |||||:...:.|:::|||||:|.|.||.||.||||||||||||||||:..|:::|||...|:.|.
Mouse   336 VFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAG 400

  Fly   387 RLYKTMKGREWKRAAFLTATLYPGIVFGTGFFLNFFIWDKSSSGAVPFTTMISLLLLWFGISVPL 451
            |||:|:||..||:.||.|||||||:|||..|.||.|||.|.|||||||.||::||.:|||||:||
Mouse   401 RLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPL 465

  Fly   452 VYLGFYLGYRKQPYQHPVRTNMIPRQVPTQHWYMNAVLSTLMAGILPFGAVFIELFFVFTAIWQN 516
            ||||:|.|:|||||.:|||||.||||:|.|.||||..:..||||||||||:||||||:|:|||:|
Mouse   466 VYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWEN 530

  Fly   517 QFYYLFGFLFLVFCILVVSCAQISIVMTYFQLCGEDYRWWWRSFVVSGGSAVYVLFYSIFYFFTK 581
            |||||||||||||.||||||:||||||.|||||.||||||||:|:||||||.|||.|:||||..|
Mouse   531 QFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNK 595

  Fly   582 LEITEFIPTLLYLGYTGLMVLTFWLLTGSIGFFAAYVFILRIYGAVKID 630
            |:|.||||:|||.|||.||||:||||||:|||:|||:|:.:||.|||||
Mouse   596 LDIVEFIPSLLYFGYTTLMVLSFWLLTGTIGFYAAYMFVRKIYAAVKID 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF4	NP_001285907.1	EMP70	57..587	CDD:281048	351/546 (64%)
Tm9sf4	XP_006500539.1	EMP70	56..601	CDD:367285	351/546 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832977
Domainoid	1	1.000	726	1.000	Domainoid score	I110
eggNOG	1	0.900	-	-		E1_KOG1278
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21620
Inparanoid	1	1.050	843	1.000	Inparanoid score	I439
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53553
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000597
OrthoInspector	1	1.000	-	-		oto92714
orthoMCL	1	0.900	-	-		OOG6_100462
Panther	1	1.100	-	-	LDO	PTHR10766
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1983
SonicParanoid	1	1.000	-	-		X358
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790