DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TM9SF4 and TM9SF4

DIOPT Version :9

Sequence 1:	NP_001285907.1	Gene:	TM9SF4 / 34778	FlyBaseID:	FBgn0028541	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_055557.2	Gene:	TM9SF4 / 9777	HGNCID:	30797	Length:	642	Species:	Homo sapiens

Alignment Length:	633	Identity:	404/633 - (63%)
Similarity:	498/633 - (78%)	Gaps:	18/633 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VLLAGVVLVADSFYVPGVAPVEFVQDQKIDVKAVKMTSSRTQLPYQYYSLRFCYPKNGTLIFKSE 78
            :||..::....:||||||||:.|.|:..:::||||:|||||||||:||||.||.|..  :.:|:|
Human    12 LLLFSLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSK--ITYKAE 74

  Fly    79 NLGEVLRGDRIVNTPYEVRMNQQVNCRLLCNQKDRPLTWSKEDSALVAERIQHEYFVHLLVDNLP 143
            |||||||||||||||::|.||.:..|.:||:|.::|:|.:.|.|.||||||..:|:|||:.||||
Human    75 NLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKPVTLTVEQSRLVAERITEDYYVHLIADNLP 139

  Fly   144 VATRIVSVNN--------PAEVTYEHGYRLGQVDGDNIYINNHLKFILSYHMHSKDK-----YRV 195
            ||||:...:|        ..:|.:|||||||..|.:.||::|||.|||.||....::     |||
Human   140 VATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEHTYRV 204

  Fly   196 VGFEVETVSVSHKELKF-HGDTCNFPD--SARPQLVNPNGETQLYFTYSVEWKESKVSWASRWDI 257
            |.|||...|:..::||. ...:|..|:  ::.||.::|..|.||||||||.|:||.:.||||||.
Human   205 VRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDT 269

  Fly   258 YLGMRDVQIHWFSIINSLVVVFFLSGILTMIMIRTLRRDIARYNTDDNIEDTLEETGWKLVHGDV 322
            ||.|.||||||||||||:||||||||||:||:|||||:|||.||.:|:||||:||:|||||||||
Human   270 YLTMSDVQIHWFSIINSVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDV 334

  Fly   323 FRPPKNTRLFSAIIGSGIQIFFMALITIFFAMLGMLSPSSRGALMTSGIFMYVFMGTIAGYYAAR 387
            ||||:...:.|:::|||||:|.|.||.||.||||||||||||||||:..|:::|||...|:.|.|
Human   335 FRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGR 399

  Fly   388 LYKTMKGREWKRAAFLTATLYPGIVFGTGFFLNFFIWDKSSSGAVPFTTMISLLLLWFGISVPLV 452
            ||:|:||..||:.||.|||||||:|||..|.||.|||.|.|||||||.||::||.:|||||:|||
Human   400 LYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLV 464

  Fly   453 YLGFYLGYRKQPYQHPVRTNMIPRQVPTQHWYMNAVLSTLMAGILPFGAVFIELFFVFTAIWQNQ 517
            |||:|.|:|||||.:|||||.||||:|.|.||||..:..||||||||||:||||||:|:|||:||
Human   465 YLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQ 529

  Fly   518 FYYLFGFLFLVFCILVVSCAQISIVMTYFQLCGEDYRWWWRSFVVSGGSAVYVLFYSIFYFFTKL 582
            ||||||||||||.||||||:||||||.|||||.||||||||:|:||||||.|||.|:||||..||
Human   530 FYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKL 594

  Fly   583 EITEFIPTLLYLGYTGLMVLTFWLLTGSIGFFAAYVFILRIYGAVKID 630
            :|.||||:|||.|||.||||:||||||:|||:|||:|:.:||.|||||
Human   595 DIVEFIPSLLYFGYTALMVLSFWLLTGTIGFYAAYMFVRKIYAAVKID 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF4	NP_001285907.1	EMP70	57..587	CDD:281048	347/545 (64%)
TM9SF4	NP_055557.2	EMP70	55..599	CDD:397233	358/559 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142853
Domainoid	1	1.000	722	1.000	Domainoid score	I110
eggNOG	1	0.900	-	-		E1_KOG1278
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21620
Inparanoid	1	1.050	843	1.000	Inparanoid score	I446
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53553
OrthoDB	1	1.010	-	-		D135708at33208
OrthoFinder	1	1.000	-	-		FOG0000597
OrthoInspector	1	1.000	-	-		oto89150
orthoMCL	1	0.900	-	-		OOG6_100462
Panther	1	1.100	-	-	LDO	PTHR10766
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1983
SonicParanoid	1	1.000	-	-		X358
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800