Protein Alignment TM9SF4 and TM9SF2

DIOPT Version :10

• Sequence 1: NP_609669.1
• Gene: TM9SF4 / 34778
• FlyBaseID: FBgn0028541
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_004791.1
• Gene: TM9SF2 / 9375
• HGNCID: 11865
• Length: 663
• Species: Homo sapiens
• Alignment Length: 673
• Identity: 292/673 - (43%)
• Similarity: 404/673 - (60%)
• Gaps: 74/673 - (10%)

  Fly     8 RPCLAIVLLAGVV---LVADSFYVPGVAPVEFVQDQK--------IDVKAVKMTSSRTQLPYQYY 61
            |..|..:||.|.|   ..:.:||:||:|||.|..::|        |::...::.|..:.|||:|.
Human    15 RLLLLSLLLLGAVPGPRRSGAFYLPGLAPVNFCDEEKKSDECKAEIELFVNRLDSVESVLPYEYT 79

  Fly    62 SLRFCYPKNGTLIFKSENLGEVLRGDRIVNTPYEVRMNQQVNCRLLCN--------QKDRPLTWS 118
            :..||....|..  .|||||:||.|:||..:||:...|::..|:|:|.        :..:.|.:.
Human    80 AFDFCQASEGKR--PSENLGQVLFGERIEPSPYKFTFNKKETCKLVCTKTYHTEKAEDKQKLEFL 142

  Fly   119 KEDSALVAERIQHEYFVHLLVDNLPVATRIVSVN------NPAEVTYEHGYRLGQV--------- 168
            |:...|   ..||    |.:|||:|| |....|.      ||       |:.:|..
Human   143 KKSMLL---NYQH----HWIVDNMPV-TWCYDVEDGQRFCNP-------GFPIGCYITDKGHAKD 192

  Fly   169 ---------DGDNIYINNHLKFILSYHMHSKDKY--RVVGFEVETVSVSHKELKFHGDTCNFPDS 222
                     :.|..||.||:...:.||:......  |:|..::|..|..|..:       :.||.
Human   193 ACVISSDFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHI-------DKPDC 250

  Fly   223 ARPQLVNPN---GETQLYFTYSVEWKE-SKVSWASRWDIYL-GMRDVQIHWFSIINSLVVVFFLS 282
            :.|.:...|   ||.::.:||||.::| .|:.||||||..| .|....|.||||:||||:|.|||
Human   251 SGPPMDISNKASGEIKIAYTYSVSFEEDDKIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLS 315

  Fly   283 GILTMIMIRTLRRDIARYNTDDNIEDTLEETGWKLVHGDVFRPPKNTRLFSAIIGSGIQIFFMAL 347
            |::.|||:|||.:||||||..|:.||..||.||||||||:||||:...|.|..:|||.||..|..
Human   316 GMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPRKGMLLSVFLGSGTQILIMTF 380

  Fly   348 ITIFFAMLGMLSPSSRGALMTSGIFMYVFMGTIAGYYAARLYKTMKGREWKRAAFLTATLYPGIV 412
            :|:|||.||.|||::||||||..:.::|.:||.|||.|||.||:..|.:||....||:.|.||||
Human   381 VTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGIV 445

  Fly   413 FGTGFFLNFFIWDKSSSGAVPFTTMISLLLLWFGISVPLVYLGFYLGYRKQPYQHPVRTNMIPRQ 477
            |...|.:|..:|.:.||.|:||.|::::|.|||.|||||.::|.|.|::|...:||||||.||||
Human   446 FADFFIMNLILWGEGSSAAIPFGTLVAILALWFCISVPLTFIGAYFGFKKNAIEHPVRTNQIPRQ 510

  Fly   478 VPTQHWYMNAVLSTLMAGILPFGAVFIELFFVFTAIWQNQFYYLFGFLFLVFCILVVSCAQISIV 542
            :|.|.:|...:...:|.||||||.:||:|||:..:||.:|.||:||||||||.|||::|::.:|:
Human   511 IPEQSFYTKPLPGIIMGGILPFGCIFIQLFFILNSIWSHQMYYMFGFLFLVFIILVITCSEATIL 575

  Fly   543 MTYFQLCGEDYRWWWRSFVVSGGSAVYVLFYSIFYFFTKLEITEFIPTLLYLGYTGLMVLTFWLL 607
            :.||.||.|||.|.||||:.||.:|||.|.|::.|||:||:||....|:||.|||.:|||.|:|.
Human   576 LCYFHLCAEDYHWQWRSFLTSGFTAVYFLIYAVHYFFSKLQITGTASTILYFGYTMIMVLIFFLF 640

  Fly   608 TGSIGFFAAYVFILRIYGAVKID 630
            ||:|||||.:.|:.:||..||:|
Human   641 TGTIGFFACFWFVTKIYSVVKVD 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF4	NP_609669.1	EMP70	57..587	CDD:460774	250/568 (44%)
TM9SF2	NP_004791.1	EMP70	75..619	CDD:460774	249/567 (44%)