DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TM9SF4 and TMN6

DIOPT Version :9

Sequence 1:	NP_001285907.1	Gene:	TM9SF4 / 34778	FlyBaseID:	FBgn0028541	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_175909.1	Gene:	TMN6 / 841956	AraportID:	AT1G55130	Length:	637	Species:	Arabidopsis thaliana

Alignment Length:	648	Identity:	313/648 - (48%)
Similarity:	428/648 - (66%)	Gaps:	46/648 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VLLAGVVLVA-------DSFYVPGVAPVEFVQDQKIDVKAVKMTSSRTQLPYQYYSLRFCYPKNG 71
            :.::|.:|::       .:||:|||||.:|.:...:.||..|::|::|||||.:|.|.:|.|..
plant     5 IRISGTLLLSFLFFSTLHAFYLPGVAPRDFQKGDPLYVKVNKLSSTKTQLPYDFYYLNYCKPPK- 68

  Fly    72 TLIFKSENLGEVLRGDRIVNTPYEVRMNQQVNCRLLCNQKDRPLTWSKEDSALVAERIQHEYFVH 136
             ::...||||||||||||.|:.|...|.:...||:.|.     :....|.:....|:|.:||..:
plant    69 -ILNTGENLGEVLRGDRIENSVYTFEMLEDQPCRVGCR-----VRVDAESAKNFREKIDYEYRAN 127

  Fly   137 LLVDNLPVATRIVSVNNPAEVTYEHGYRL---GQVDGD---NIYINNHLKFILSYHM-HSKDKYR 194
            :::||||||......:.....|||||||:   |..:|.   ..:|:|||.|.:.||. ...:..|
plant   128 MILDNLPVAVLRQRKDGIQSTTYEHGYRVGFKGSYEGSKEKKYFIHNHLSFRVMYHRDQESESSR 192

  Fly   195 VVGFEVETVSVSHKELKFHGDTCNFPDSARPQLVNPNGET-----------------QLYFTYSV 242
            :|||||...||.|:..::        |...|||...|.:|                 ::.|||.|
plant   193 IVGFEVTPNSVLHEYKEW--------DENNPQLTTCNKDTKNLIQSNTVPQEVEEGKEIVFTYDV 249

  Fly   243 EWKESKVSWASRWDIYLGMRDVQIHWFSIINSLVVVFFLSGILTMIMIRTLRRDIARYNTDDNIE 307
            .:|||.:.||||||.||.|.|.|||||||||||::|.||||::.|||:|||.:||:.||..:..:
plant   250 AFKESVIKWASRWDTYLLMNDDQIHWFSIINSLMIVLFLSGMVAMIMMRTLYKDISNYNQLETQD 314

  Fly   308 DTLEETGWKLVHGDVFRPPKNTRLFSAIIGSGIQIFFMALITIFFAMLGMLSPSSRGALMTSGIF 372
            :..||||||||||||||.|.|:.|....:|:|:|||.|.|:|:.||:||.||||:||.|.|:.:.
plant   315 EAQEETGWKLVHGDVFRTPMNSGLLCVYVGTGVQIFGMTLVTMIFALLGFLSPSNRGGLTTAMVL 379

  Fly   373 MYVFMGTIAGYYAARLYKTMKGREWKRAAFLTATLYPGIVFGTGFFLNFFIWDKSSSGAVPFTTM 437
            ::||||..|||.::||:|..||.||||....||.::|||:|...|.||..||.:.||||:||:||
plant   380 LWVFMGIFAGYSSSRLHKMFKGNEWKRITLKTAFMFPGILFAIFFVLNTLIWGERSSGAIPFSTM 444

  Fly   438 ISLLLLWFGISVPLVYLGFYLGYRKQPYQHPVRTNMIPRQVPTQHWYMNAVLSTLMAGILPFGAV 502
            .:|:.||||||||||::|.|||::|...:.||:||.||||||.|.|||....|.|:.||||||||
plant   445 FALVCLWFGISVPLVFIGSYLGHKKPAIEDPVKTNKIPRQVPEQPWYMKPGFSILIGGILPFGAV 509

  Fly   503 FIELFFVFTAIWQNQFYYLFGFLFLVFCILVVSCAQISIVMTYFQLCGEDYRWWWRSFVVSGGSA 567
            ||||||:.|:||.|||||:|||||:||.||:|:||:|:||:.|||||.|||.|.||:::.||.|:
plant   510 FIELFFILTSIWLNQFYYIFGFLFIVFLILIVTCAEITIVLCYFQLCSEDYNWCWRAYLTSGSSS 574

  Fly   568 VYVLFYSIFYFFTKLEITEFIPTLLYLGYTGLMVLTFWLLTGSIGFFAAYVFILRIYGAVKID 630
            :|:..||:|||||||||::.:..:||.||..::..:|::|||||||:|...|:.:||.:||||
plant   575 LYLFLYSVFYFFTKLEISKLVSGVLYFGYMIIISYSFFVLTGSIGFYACLWFVRKIYSSVKID 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF4	NP_001285907.1	EMP70	57..587	CDD:281048	276/553 (50%)
TMN6	NP_175909.1	EMP70	55..594	CDD:397233	276/553 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	569	1.000	Domainoid score	I44
eggNOG	1	0.900	-	-		E1_KOG1278
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21620
Inparanoid	1	1.050	649	1.000	Inparanoid score	I171
OMA	1	1.010	-	-		QHG53553
OrthoDB	1	1.010	-	-		D641127at2759
OrthoFinder	1	1.000	-	-		FOG0000597
OrthoInspector	1	1.000	-	-		otm3057
orthoMCL	1	0.900	-	-		OOG6_100462
Panther	1	1.100	-	-	O	PTHR10766
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X358
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840