DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TM9SF4 and TM9SF3

DIOPT Version :9

Sequence 1:	NP_001285907.1	Gene:	TM9SF4 / 34778	FlyBaseID:	FBgn0028541	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_011538278.1	Gene:	TM9SF3 / 56889	HGNCID:	21529	Length:	607	Species:	Homo sapiens

Alignment Length:	589	Identity:	204/589 - (34%)
Similarity:	315/589 - (53%)	Gaps:	67/589 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 QLPYQYYSLRFCYPKNGTLIFKSENLGEVLRGDRIVNTPYEVRMNQQVNCRLLCNQKDRPLTWSK 119
            |..|:|:||.||.....::....|.|||.|:|..:..:..:::....|.....|   :..|...|
Human    73 QETYKYFSLPFCVGSKKSISHYHETLGEALQGVELEFSGLDIKFKDDVMPATYC---EIDLDKEK 134

  Fly   120 EDSALVAERIQHEYFVHLLVDNLPVATRIVSVNNPAEVTYEHGYRLGQVD--GDNIYINNHLKFI 182
            .|:.:.|  |::.|:..:.:|:||:...:                 |:.|  |::.|:..:.|.
Human   135 RDAFVYA--IKNHYWYQMYIDDLPIWGIV-----------------GEADENGEDYYLWTYKKL- 179

  Fly   183 LSYHMHSKDKYRVVGFEVETVSVSHKELKFHGD---TCNFPDSARPQLVNPNGETQLYFTYSVEW 244
                                      |:.|:|:   ..|.....:.:|| ||  |::..:|||:|
Human   180 --------------------------EIGFNGNRIVDVNLTSEGKVKLV-PN--TKIQMSYSVKW 215

  Fly   245 KESKVSWASRWDIYLGMRDVQ--IHWFSIINSLVVVFFLSGILTMIMIRTLRRDIARYN----TD 303
            |:|.|.:..|:|.||.....|  ||||||.||.::|.||.|:::||::||||:|.|||:    .|
Human   216 KKSDVKFEDRFDKYLDPSFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKEEEMD 280

  Fly   304 DNIEDTLEETGWKLVHGDVFRPPKNTRLFSAIIGSGIQIFFMALITIFFAMLGMLSPSSRGALMT 368
            |...|..:|.|||.||||||||..:..:||::||||.|||.::||.|..||:..|. :.||::::
Human   281 DMDRDLGDEYGWKQVHGDVFRPSSHPLIFSSLIGSGCQIFAVSLIVIIVAMIEDLY-TERGSMLS 344

  Fly   369 SGIFMYVFMGTIAGYYAARLYKTMKGREWKRAAFLTATLYPGIVFGTGFFLNFFIWDKSSSGAVP 433
            :.||:|.....:.||:...||....||.|.:..|:.|.|.|.:|.||.||:||......:|.|:|
Human   345 TAIFVYAATSPVNGYFGGSLYARQGGRRWIKQMFIGAFLIPAMVCGTAFFINFIAIYYHASRAIP 409

  Fly   434 FTTMISLLLLWFGISVPLVYLGFYLG--YRKQPYQHPVRTNMIPRQVPTQHWYMNAVLSTLMAGI 496
            |.||:::..:.|.:.:||..:|..||  ...|| ..|.|.|.:||.:|.:.|:|...:...:.||
Human   410 FGTMVAVCCICFFVILPLNLVGTILGRNLSGQP-NFPCRVNAVPRPIPEKKWFMEPAVIVCLGGI 473

  Fly   497 LPFGAVFIELFFVFTAIWQNQFYYLFGFLFLVFCILVVSCAQISIVMTYFQLCGEDYRWWWRSFV 561
            ||||::|||::|:||:.|..:.||::||:.||..||.:....::||.|||.|..|||||.|.||:
Human   474 LPFGSIFIEMYFIFTSFWAYKIYYVYGFMMLVLVILCIVTVCVTIVCTYFLLNAEDYRWQWTSFL 538

  Fly   562 VSGGSAVYVLFYSIFYFFTKLEITEFIPTLLYLGYTGLMVLTFWLLTGSIGFFAAYVFILRIYGA 626
            .:..:|:||..||.:|:|.|.::.....|..|.||..:......::.|:||:.....|:.:||..
Human   539 SAASTAIYVYMYSFYYYFFKTKMYGLFQTSFYFGYMAVFSTALGIMCGAIGYMGTSAFVRKIYTN 603

  Fly   627 VKID 630
            ||||
Human   604 VKID 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF4	NP_001285907.1	EMP70	57..587	CDD:281048	189/542 (35%)
TM9SF3	XP_011538278.1	EMP70	75..545	CDD:281048	181/523 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1278
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53553
OrthoDB	1	1.010	-	-		D135708at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830