Protein Alignment TM9SF4 and TM9SF3

DIOPT Version :10

• Sequence 1: NP_609669.1
• Gene: TM9SF4 / 34778
• FlyBaseID: FBgn0028541
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: XP_011538278.1
• Gene: TM9SF3 / 56889
• HGNCID: 21529
• Length: 607
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 204/589 - (34%)
• Similarity: 315/589 - (53%)
• Gaps: 67/589 - (11%)

  Fly    55 QLPYQYYSLRFCYPKNGTLIFKSENLGEVLRGDRIVNTPYEVRMNQQVNCRLLCNQKDRPLTWSK 119
            |..|:|:||.||.....::....|.|||.|:|..:..:..:::....|.....|   :..|...|
Human    73 QETYKYFSLPFCVGSKKSISHYHETLGEALQGVELEFSGLDIKFKDDVMPATYC---EIDLDKEK 134

  Fly   120 EDSALVAERIQHEYFVHLLVDNLPVATRIVSVNNPAEVTYEHGYRLGQVD--GDNIYINNHLKFI 182
            .|:.:.|  |::.|:..:.:|:||:...:                 |:.|  |::.|:..:.|.
Human   135 RDAFVYA--IKNHYWYQMYIDDLPIWGIV-----------------GEADENGEDYYLWTYKKL- 179

  Fly   183 LSYHMHSKDKYRVVGFEVETVSVSHKELKFHGD---TCNFPDSARPQLVNPNGETQLYFTYSVEW 244
                                      |:.|:|:   ..|.....:.:|| ||  |::..:|||:|
Human   180 --------------------------EIGFNGNRIVDVNLTSEGKVKLV-PN--TKIQMSYSVKW 215

  Fly   245 KESKVSWASRWDIYLGMRDVQ--IHWFSIINSLVVVFFLSGILTMIMIRTLRRDIARYN----TD 303
            |:|.|.:..|:|.||.....|  ||||||.||.::|.||.|:::||::||||:|.|||:    .|
Human   216 KKSDVKFEDRFDKYLDPSFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKEEEMD 280

  Fly   304 DNIEDTLEETGWKLVHGDVFRPPKNTRLFSAIIGSGIQIFFMALITIFFAMLGMLSPSSRGALMT 368
            |...|..:|.|||.||||||||..:..:||::||||.|||.::||.|..||:..|. :.||::::
Human   281 DMDRDLGDEYGWKQVHGDVFRPSSHPLIFSSLIGSGCQIFAVSLIVIIVAMIEDLY-TERGSMLS 344

  Fly   369 SGIFMYVFMGTIAGYYAARLYKTMKGREWKRAAFLTATLYPGIVFGTGFFLNFFIWDKSSSGAVP 433
            :.||:|.....:.||:...||....||.|.:..|:.|.|.|.:|.||.||:||......:|.|:|
Human   345 TAIFVYAATSPVNGYFGGSLYARQGGRRWIKQMFIGAFLIPAMVCGTAFFINFIAIYYHASRAIP 409

  Fly   434 FTTMISLLLLWFGISVPLVYLGFYLG--YRKQPYQHPVRTNMIPRQVPTQHWYMNAVLSTLMAGI 496
            |.||:::..:.|.:.:||..:|..||  ...|| ..|.|.|.:||.:|.:.|:|...:...:.||
Human   410 FGTMVAVCCICFFVILPLNLVGTILGRNLSGQP-NFPCRVNAVPRPIPEKKWFMEPAVIVCLGGI 473

  Fly   497 LPFGAVFIELFFVFTAIWQNQFYYLFGFLFLVFCILVVSCAQISIVMTYFQLCGEDYRWWWRSFV 561
            ||||::|||::|:||:.|..:.||::||:.||..||.:....::||.|||.|..|||||.|.||:
Human   474 LPFGSIFIEMYFIFTSFWAYKIYYVYGFMMLVLVILCIVTVCVTIVCTYFLLNAEDYRWQWTSFL 538

  Fly   562 VSGGSAVYVLFYSIFYFFTKLEITEFIPTLLYLGYTGLMVLTFWLLTGSIGFFAAYVFILRIYGA 626
            .:..:|:||..||.:|:|.|.::.....|..|.||..:......::.|:||:.....|:.:||..
Human   539 SAASTAIYVYMYSFYYYFFKTKMYGLFQTSFYFGYMAVFSTALGIMCGAIGYMGTSAFVRKIYTN 603

  Fly   627 VKID 630
            ||||
Human   604 VKID 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF4	NP_609669.1	EMP70	57..587	CDD:460774	189/542 (35%)
TM9SF3	XP_011538278.1	EMP70	75..545	CDD:460774	181/523 (35%)