DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TM9SF4 and Tm9sf1

DIOPT Version :9

Sequence 1:	NP_001285907.1	Gene:	TM9SF4 / 34778	FlyBaseID:	FBgn0028541	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	XP_038949417.1	Gene:	Tm9sf1 / 361043	RGDID:	1307085	Length:	606	Species:	Rattus norvegicus

Alignment Length:	641	Identity:	211/641 - (32%)
Similarity:	325/641 - (50%)	Gaps:	68/641 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CLAIVLLA-----GVVLVADSFYVPGVAPVEFVQDQKIDVKAVKMTSSRTQLPYQYYSLRFCYPK 69
            ||.:::|.     |..:...:.|.||...:.:|  .|:.      .....|..|.||.|..|.|:
  Rat    14 CLPVLILLLGIGHGPRVEGVTHYKPGDPVILYV--NKVG------PYHNPQETYHYYQLPVCCPE 70

  Fly    70 NGTLIFKSENLGEVLRGDRIVNTPYEVRMNQQVNCRLLCNQKDRPLTWSKEDSALVAERIQHEYF 134
            .  :..||.:|||||.|||:..:.||:|..:.|..|:||:     :..|......:.:.|:..|:
  Rat    71 K--IRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCH-----MQLSSAQVEQLRQAIEELYY 128

  Fly   135 VHLLVDNLPVATRIVSVNNPAEVTYEHGYRLGQVDGDNIYINNHLKFILSYHMHSKDKYRVVGFE 199
            ...:||:||:...:..:.....:.:.|          .|.:..||.|.|.:|          |..
  Rat   129 FEFVVDDLPIRGFVGYMEESGFLPHSH----------KIGLWTHLDFHLEFH----------GDR 173

  Fly   200 VETVSVSHKELKFHGDTCNFPDSAR-PQLVNPNGETQLYFTYSVEWKESKVSWAS----RWDIYL 259
            :...:||.:::|.|.     .|..| .:|:.      |..||||.|.|:.|...|    ..|...
  Rat   174 IIFANVSVRDVKPHS-----LDGLRSDELLG------LTHTYSVRWSETSVEHRSDRRRADDGGF 227

  Fly   260 GMRDVQIHWFSIINSLVVVFFLSGILTMIMIRTLRRDIARYNTDDNI-----EDTLE--ETGWKL 317
            ..|.::|||.|||||:|:||.|.|.:.:|::|.||.|:||||.|:..     .|..:  :.|||:
  Rat   228 FPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETSSGGSSDDFDQGDNGWKI 292

  Fly   318 VHGDVFRPPKNTRLFSAIIGSGIQIFFMALIT--IFFAMLGMLSPSSRGALMTSGIFMYVFMGTI 380
            :|.||||.|....|..|::|.|.|  |:||.|  |..|:|||.:....||:.::.|.:|.....|
  Rat   293 IHTDVFRFPPCRGLLCAVLGVGAQ--FLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCI 355

  Fly   381 AGYYAARLYKTMKGREWKRAAFLTATLYPGIVFGTGFFLNFFIWDKSSSGAVPFTTMISLLLLWF 445
            :||.::..|:.:.|..|.....||.:|:....|.|...:|...|...|:.|:|.||::.||.:|.
  Rat   356 SGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPVTTILLLLTVWL 420

  Fly   446 GISVPLVYLGFYLGYRK-QPYQHPVRTNMIPRQVPTQHWYMNAVLSTLMAGILPFGAVFIELFFV 509
            .:..||..:|...|... .|:..|.||..|.|::|.|.||.:.|:...:.|.|||.|:.:||:::
  Rat   421 LVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTVIHMTVGGFLPFSAISVELYYI 485

  Fly   510 FTAIWQNQFYYLFGFLFLVFCILVVSCAQISIVMTYFQLCGEDYRWWWRSFVVSGGSAVYVLFYS 574
            |..:|..:.|.|:|.||.||.||:...|.|||.:|||||.||||||||||.:..|.:.:::..||
  Rat   486 FATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYS 550

  Fly   575 IFYFFTKLEITEFIPTLLYLGYTGLMVLTFWLLTGSIGFFAAYVFILRIYGAVKID 630
            :||:..:..::..:.|:.:.||:.|....|:|:.|:|.||::..||..||..:|:|
  Rat   551 VFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF4	NP_001285907.1	EMP70	57..587	CDD:281048	185/544 (34%)
Tm9sf1	XP_038949417.1	EMP70	59..562	CDD:397233	185/542 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1278
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53553
OrthoDB	1	1.010	-	-		D135708at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830