DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TM9SF4 and Tm9sf3

DIOPT Version :9

Sequence 1:	NP_001285907.1	Gene:	TM9SF4 / 34778	FlyBaseID:	FBgn0028541	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_579930.1	Gene:	Tm9sf3 / 107358	MGIID:	1914262	Length:	587	Species:	Mus musculus

Alignment Length:	589	Identity:	204/589 - (34%)
Similarity:	315/589 - (53%)	Gaps:	67/589 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 QLPYQYYSLRFCYPKNGTLIFKSENLGEVLRGDRIVNTPYEVRMNQQVNCRLLCNQKDRPLTWSK 119
            |..|:|:||.||.....::....|.|||.|:|..:..:..:::....|.....|   :..|...|
Mouse    53 QETYKYFSLPFCVGSKKSISHYHETLGEALQGVELEFSGLDIKFKDDVMPGTYC---EIDLDKEK 114

  Fly   120 EDSALVAERIQHEYFVHLLVDNLPVATRIVSVNNPAEVTYEHGYRLGQVD--GDNIYINNHLKFI 182
            .|:.:.|  |::.|:..:.:|:||:...:                 |:.|  |::.|:..:.|.
Mouse   115 RDAFVYA--IKNHYWYQMYIDDLPIWGIV-----------------GEADENGEDYYLWTYKKL- 159

  Fly   183 LSYHMHSKDKYRVVGFEVETVSVSHKELKFHGD---TCNFPDSARPQLVNPNGETQLYFTYSVEW 244
                                      |:.|:|:   ..|.....:.:|| ||  |::..:|||:|
Mouse   160 --------------------------EIGFNGNRIVDVNLTSEGKVKLV-PN--TKIQMSYSVKW 195

  Fly   245 KESKVSWASRWDIYLGMRDVQ--IHWFSIINSLVVVFFLSGILTMIMIRTLRRDIARYN----TD 303
            |:|.|.:..|:|.||.....|  ||||||.||.::|.||.|:::||::||||:|.|||:    .|
Mouse   196 KKSDVKFEDRFDKYLDPSFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKEEEMD 260

  Fly   304 DNIEDTLEETGWKLVHGDVFRPPKNTRLFSAIIGSGIQIFFMALITIFFAMLGMLSPSSRGALMT 368
            |...|..:|.|||.||||||||..:..:||::||||.|||.::||.|..||:..|. :.||::::
Mouse   261 DMDRDLGDEYGWKQVHGDVFRPSSHPLIFSSLIGSGCQIFAVSLIVIIVAMIEDLY-TERGSMLS 324

  Fly   369 SGIFMYVFMGTIAGYYAARLYKTMKGREWKRAAFLTATLYPGIVFGTGFFLNFFIWDKSSSGAVP 433
            :.||:|.....:.||:...||....||.|.:..|:.|.|.|.:|.||.||:||......:|.|:|
Mouse   325 TAIFVYAATSPVNGYFGGSLYARQGGRRWIKQMFIGAFLIPAMVCGTAFFINFIAIYYHASRAIP 389

  Fly   434 FTTMISLLLLWFGISVPLVYLGFYLG--YRKQPYQHPVRTNMIPRQVPTQHWYMNAVLSTLMAGI 496
            |.||:::..:.|.:.:||..:|..||  ...|| ..|.|.|.:||.:|.:.|:|...:...:.||
Mouse   390 FGTMVAVCCICFFVILPLNLVGTILGRNLSGQP-NFPCRVNAVPRPIPEKKWFMEPAVIVCLGGI 453

  Fly   497 LPFGAVFIELFFVFTAIWQNQFYYLFGFLFLVFCILVVSCAQISIVMTYFQLCGEDYRWWWRSFV 561
            ||||::|||::|:||:.|..:.||::||:.||..||.:....::||.|||.|..|||||.|.||:
Mouse   454 LPFGSIFIEMYFIFTSFWAYKIYYVYGFMMLVLVILCIVTVCVTIVCTYFLLNAEDYRWQWTSFL 518

  Fly   562 VSGGSAVYVLFYSIFYFFTKLEITEFIPTLLYLGYTGLMVLTFWLLTGSIGFFAAYVFILRIYGA 626
            .:..:|:||..||.:|:|.|.::.....|..|.||..:......::.|:||:.....|:.:||..
Mouse   519 SAASTAIYVYMYSFYYYFFKTKMYGLFQTSFYFGYMAVFSTALGIMCGAIGYMGTSAFVRKIYTN 583

  Fly   627 VKID 630
            ||||
Mouse   584 VKID 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF4	NP_001285907.1	EMP70	57..587	CDD:281048	189/542 (35%)
Tm9sf3	NP_579930.1	EMP70	56..525	CDD:397233	181/522 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53553
OrthoDB	1	1.010	-	-		D135708at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930