Protein Alignment TM9SF4 and TM9SF1

DIOPT Version :10

• Sequence 1: NP_609669.1
• Gene: TM9SF4 / 34778
• FlyBaseID: FBgn0028541
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_006396.2
• Gene: TM9SF1 / 10548
• HGNCID: 11864
• Length: 606
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 204/595 - (34%)
• Similarity: 308/595 - (51%)
• Gaps: 63/595 - (10%)

  Fly    55 QLPYQYYSLRFCYPKNGTLIFKSENLGEVLRGDRIVNTPYEVRMNQQVNCRLLCNQKDRPLTWSK 119
            |..|.||.|..|.|:.  :..||.:|||||.|||:..:.||:|..:.|..|:||:     :..|.
Human    56 QETYHYYQLPVCCPEK--IRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCH-----MQLSS 113

  Fly   120 EDSALVAERIQHEYFVHLLVDNLPVATRIVSVNNPAEVTYEHGYRLGQVDGDNIYINNHLKFILS 184
            .....:.:.|:..|:...:||:||:...:..:.....:.:.|          .|.:..||.|.|.
Human   114 AQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSH----------KIGLWTHLDFHLE 168

  Fly   185 YHMHSKDKYRVVGFEVETVSVSHKELKFHGDTCNFPDSARPQLVNPNGETQLYFTYSVEWKESKV 249
            :|          |..:...:||.:::|.|.     .|..|     |:....|..||||.|.|:.|
Human   169 FH----------GDRIIFANVSVRDVKPHS-----LDGLR-----PDEFLGLTHTYSVRWSETSV 213

  Fly   250 SWASRWDIYLG------MRDVQIHWFSIINSLVVVFFLSGILTMIMIRTLRRDIARYNTDDNIED 308
            .  .|.|...|      .|.::|||.|||||:|:||.|.|.:.:|::|.||.|:||||.|   |:
Human   214 E--RRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLD---EE 273

  Fly   309 TLE----------ETGWKLVHGDVFRPPKNTRLFSAIIGSGIQIFFMALIT--IFFAMLGMLSPS 361
            |..          :.|||::|.||||.|....|..|::|.|.|  |:||.|  |..|:|||.:..
Human   274 TTSAGSGDDFDQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQ--FLALGTGIIVMALLGMFNVH 336

  Fly   362 SRGALMTSGIFMYVFMGTIAGYYAARLYKTMKGREWKRAAFLTATLYPGIVFGTGFFLNFFIWDK 426
            ..||:.::.|.:|.....|:||.::..|:.:.|..|.....||.:|:....|.|...:|...|..
Human   337 RHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWAN 401

  Fly   427 SSSGAVPFTTMISLLLLWFGISVPLVYLGFYLGYRK-QPYQHPVRTNMIPRQVPTQHWYMNAVLS 490
            .|:.|:|.||::.||.:|..:..||..:|...|... .|:..|.||..|.|::|.|.||.:.|:.
Human   402 GSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTVIH 466

  Fly   491 TLMAGILPFGAVFIELFFVFTAIWQNQFYYLFGFLFLVFCILVVSCAQISIVMTYFQLCGEDYRW 555
            ..:.|.|||.|:.:||:::|..:|..:.|.|:|.||.||.||:...|.|||.:|||||.||||||
Human   467 MTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRW 531

  Fly   556 WWRSFVVSGGSAVYVLFYSIFYFFTKLEITEFIPTLLYLGYTGLMVLTFWLLTGSIGFFAAYVFI 620
            ||||.:..|.:.:::..||:||:..:..::..:.|:.:.||:.|....|:|:.|:|.||::..||
Human   532 WWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFI 596

  Fly   621 LRIYGAVKID 630
            ..||..:|:|
Human   597 RYIYVNLKMD 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF4	NP_609669.1	EMP70	57..587	CDD:460774	187/548 (34%)
TM9SF1	NP_006396.2	EMP70	58..562	CDD:460774	187/547 (34%)