DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9014 and TRAF7

DIOPT Version :9

Sequence 1:	NP_001285905.1	Gene:	CG9014 / 34777	FlyBaseID:	FBgn0028847	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_115647.2	Gene:	TRAF7 / 84231	HGNCID:	20456	Length:	670	Species:	Homo sapiens

Alignment Length:	322	Identity:	60/322 - (18%)
Similarity:	106/322 - (32%)	Gaps:	116/322 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ELICPICTDVLEEPVQSSECEHAFCRACIDKWMIQKQICPVDRSGL-LTSHLVPVSRLMRNMLSR 78
            :|.|.:|..|.::||.:: |.|.|||.|    .::.:.||||...| :..:.:.|:..:..:...
Human   128 KLCCQLCCSVFKDPVITT-CGHTFCRRC----ALKSEKCPVDNVKLTVVVNNIAVAEQIGELFIH 187

  Fly    79 LKIKCTFSQS-----------GCAQMLALEEFRTHVAACEHNPKVVVEC---------------- 116
            .:..|..:.|           ||...:.|...:.|..:|::.|   |.|
Human   188 CRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRP---VRCPNNPSCPPLLRMNLEA 249

  Fly   117 ------------SK-GCGMKVPKDEMSRH--NCVFE----------------------------- 137
                        || ||.....:|....|  .|.||
Human   250 HLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAF 314

  Fly   138 LRELVEKLAKEVSDLK-----------QKQSDMEEQSSSQRREMELFQYYIAALRSTNPMLRNIG 191
            ||.::.||::::..|:           :.||.:.|.....||:..:.          |..|.:|.
Human   315 LRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASML----------NDELSHIN 369

  Fly   192 EQLDRFSLMQW-------------GHGLPL--ANIHTWGSLISTPDNPMHLMVRDVLRESGC 238
            .:|:...|..:             ||..|:  ..:::.|.|:.:..:...:.|.|......|
Human   370 ARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKC 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9014	NP_001285905.1	zf-C3HC4	18..55	CDD:278524	12/36 (33%)
CG9014	NP_001285905.1	USP8_interact	137..319	CDD:286082	24/157 (15%)
TRAF7	NP_115647.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..97
		RING	131..163	CDD:214546	12/36 (33%)
		Sina	207..>280	CDD:302762	14/75 (19%)
		DD_cGKI	282..322	CDD:213458	5/39 (13%)
		WD40	<380..668	CDD:225201	8/52 (15%)
		WD40	388..668	CDD:238121	8/44 (18%)
		WD 1. /evidence=ECO:0000255	394..433		8/38 (21%)
		WD 2. /evidence=ECO:0000255	437..474
		WD40 repeat	443..477	CDD:293791
		WD 3. /evidence=ECO:0000255	477..513
		WD40 repeat	482..517	CDD:293791
		WD 4. /evidence=ECO:0000255	515..554
		WD40 repeat	527..556	CDD:293791
		WD 5. /evidence=ECO:0000255	557..594
		WD40 repeat	562..596	CDD:293791
		WD 6. /evidence=ECO:0000255	597..638
		WD40 repeat	604..639	CDD:293791
		WD 7. /evidence=ECO:0000255	641..669
		WD40 repeat	646..668	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810