DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9014 and TRAF6

DIOPT Version :9

Sequence 1:	NP_001285905.1	Gene:	CG9014 / 34777	FlyBaseID:	FBgn0028847	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_004611.1	Gene:	TRAF6 / 7189	HGNCID:	12036	Length:	522	Species:	Homo sapiens

Alignment Length:	373	Identity:	74/373 - (19%)
Similarity:	116/373 - (31%)	Gaps:	159/373 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CPICTDVLEEPVQSSECEHAFCRACIDKWMIQK-QICPVDRSGLLTSHLVPVSRLMRNMLSRLKI 81
            ||||...|.|.|| :.|.|.||:|||.|.:... ..||||...||.:.|.|.:...|.:|| |.:
Human    70 CPICLMALREAVQ-TPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILS-LMV 132

  Fly    82 KCTFSQSGCAQMLALEEFRTHVAACEH-----------------NPKVVVECSK----------- 118
            ||  ...||...:.|.....|.|.||.                 |..::.:|.:
Human   133 KC--PNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAAS 195

  Fly   119 ----------------------------------------------------GCGMKVPKDEMSR 131
                                                                ||..|:.::.::|
Human   196 MAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLAR 260

  Fly   132 H---NCVFELRELVEKL--------AKEVSDLKQKQSDMEE------QSSSQRRE----MELFQY 175
            |   |....:|.|.:.:        :..:|:::..|..:.:      :...|.||    ||....
Human   261 HLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSM 325

  Fly   176 YIAALRSTNPMLRNIGEQLDRFSLMQWGHGLPLANIHTWGSLISTPDNPMHLMVRDVLRESGCPM 240
            |::.|:.|   :|.:.:::......|. :|:.:..|..:|         |||
Human   326 YVSELKRT---IRTLEDKVAEIEAQQC-NGIYIWKIGNFG---------MHL------------- 364

  Fly   241 HMLNMLVERCHEDRWPEGLMTLDDRRENQHLMSRYVTRLVPGLVIGKP 288
                    :|.|:..|                   |....||...|||
Human   365 --------KCQEEEKP-------------------VVIHSPGFYTGKP 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9014	NP_001285905.1	zf-C3HC4	18..55	CDD:278524	17/37 (46%)
CG9014	NP_001285905.1	USP8_interact	137..319	CDD:286082	29/170 (17%)
TRAF6	NP_004611.1	Interaction with TAX1BP1. /evidence=ECO:0000269\|PubMed:10920205	1..354		60/291 (21%)
		RING	69..107	CDD:238093	17/37 (46%)
		zf-TRAF	204..261	CDD:280357	3/56 (5%)
		MATH_TRAF6	351..500	CDD:239745	15/84 (18%)
		Interaction with TANK. /evidence=ECO:0000269\|PubMed:25861989	355..522		14/80 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D918518at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820