DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9014 and TRAF5

DIOPT Version :9

Sequence 1:	NP_001285905.1	Gene:	CG9014 / 34777	FlyBaseID:	FBgn0028847	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	XP_011508259.1	Gene:	TRAF5 / 7188	HGNCID:	12035	Length:	631	Species:	Homo sapiens

Alignment Length:	325	Identity:	61/325 - (18%)
Similarity:	115/325 - (35%)	Gaps:	114/325 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VGHVDEELICPICTDVLEEPVQSSECEHAFCRACI--DKWMIQKQICPVDRSGLLTSHLVPVSRL 71
            |..::|...|..|..||..|.|:. |.|.||:.||  .:.:....|||||:..:.:..:...:..
Human   100 VERLEERYKCAFCHSVLHNPHQTG-CGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCC 163

  Fly    72 MRNMLS------------------RLKI-------------KCTF-----SQSGCAQMLALEEFR 100
            .|.:|:                  |.::             :|.|     |...|.:.:..::.:
Human   164 KREVLNLYVYCSNAPGCNAKVILGRYQVPLACCYLLQDHLQQCLFQPVQCSNEKCREPVLRKDLK 228

  Fly   101 THVAA-----------C------------EHN--PKVVVECSKGCGMKVPKDEMSRH-------- 132
            .|::|           |            |.|  |:..|.|...|...:.|.|:..|
Human   229 EHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAE 293

  Fly   133 -NCVFE--------------------LRE----LVEK---LAKEVSD----LKQKQSDMEEQSSS 165
             :|.|:                    |||    ::||   |.:::||    |:||:|.:::.:.:
Human   294 QDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAET 358

  Fly   166 QRREMELFQYYIAALRSTNPMLRNI---GEQLDRFSLMQWGHGLPLANIHTWGSLISTPDNPMHL 227
            .::..:.|:.:..........|.||   ...:|:.:.::       |.:|....:::...|...|
Human   359 IKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLE-------AQVHQLLQMVNQQQNKFDL 416

Fly 228 227
Human 417 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9014	NP_001285905.1	zf-C3HC4	18..55	CDD:278524	14/38 (37%)
CG9014	NP_001285905.1	USP8_interact	137..319	CDD:286082	21/125 (17%)
TRAF5	XP_011508259.1	RING	109..145	CDD:214546	12/36 (33%)
		zf-TRAF	202..257	CDD:280357	7/54 (13%)
		zf-TRAF	257..315	CDD:280357	11/57 (19%)
		MATH	478..624	CDD:295307
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D918518at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820