DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9014 and TRAF3

DIOPT Version :9

Sequence 1:	NP_001285905.1	Gene:	CG9014 / 34777	FlyBaseID:	FBgn0028847	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_003291.2	Gene:	TRAF3 / 7187	HGNCID:	12033	Length:	568	Species:	Homo sapiens

Alignment Length:	270	Identity:	60/270 - (22%)
Similarity:	93/270 - (34%)	Gaps:	97/270 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VDEELICPICTDVLEEPVQSSECEHAFCRACIDKWMIQKQ-ICPVDRSGLLTSHLVPVSRLMRNM 75
            |:::..|..|..||..|.| :||.|.||.:|:...:.... .|...:..::...:...:...|.:
Human    47 VEDKYKCEKCHLVLCSPKQ-TECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREI 110

  Fly    76 LSRLKIKCTFSQSGCAQMLAL-----------------------------EEFRTHV-------- 103
            |: |:|.|.....|||:.|.|                             ::.|.||
Human   111 LA-LQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYRE 174

  Fly   104 AACEH-----------------NPKVVVECSKGCGMK-VPKDEMS----------------RHNC 134
            |.|.|                 .|.|||.|...|.:: :.:.|:|                |:.|
Human   175 ATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGC 239

  Fly   135 VFE--------------------LRELVEKLAKEVSDLKQKQSDMEEQSSSQRREMELFQYYIAA 179
            ||:                    |:|....|.|:|| |.|.:| :|:..|.|....::..:.|..
Human   240 VFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVS-LLQNES-VEKNKSIQSLHNQICSFEIEI 302

  Fly   180 LRSTNPMLRN 189
            .|. ..||||
Human   303 ERQ-KEMLRN 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9014	NP_001285905.1	zf-C3HC4	18..55	CDD:278524	13/37 (35%)
CG9014	NP_001285905.1	USP8_interact	137..319	CDD:286082	18/73 (25%)
TRAF3	NP_003291.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		zf-C3HC4	56..91	CDD:278524	12/35 (34%)
		zf-TRAF	136..192	CDD:280357	6/55 (11%)
		zf-TRAF	197..247	CDD:280357	12/49 (24%)
		BBP1_C	<263..>321	CDD:291921	18/52 (35%)
		Spc29	<307..>366	CDD:293687	4/5 (80%)
		MATH_TRAF3	378..563	CDD:239746
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D918518at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820