DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9014 and TRAF2

DIOPT Version :9

Sequence 1:	NP_001285905.1	Gene:	CG9014 / 34777	FlyBaseID:	FBgn0028847	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_066961.2	Gene:	TRAF2 / 7186	HGNCID:	12032	Length:	501	Species:	Homo sapiens

Alignment Length:	272	Identity:	49/272 - (18%)
Similarity:	84/272 - (30%)	Gaps:	108/272 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GFDLNCIVGHVDEELICPICTDVLEEPVQSSECEHAF---------------CRACIDKWMIQKQ 51
            ||....:...::.:.:|..|.:||..|.| ::|.|.:               |.||:.:.:.::.
Human    18 GFSKTLLGTKLEAKYLCSACRNVLRRPFQ-AQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEG 81

  Fly    52 ICPVDRSGLLTSHLVPVSRLMRNMLSRLKIKCTFSQSGCAQMLALEEFR-----------THVAA 105
            |..::.|.....:..      |..:..|...|  ...||.....|:|:.           |...|
Human    82 ISILESSSAFPDNAA------RREVESLPAVC--PSDGCTWKGTLKEYESCHEGRCPLMLTECPA 138

  Fly   106 C-------------EHN---------------------------PKVVVECSKGCG-MKVPKDEM 129
            |             ||.                           ||..:.|. ||| .|:|:::.
Human   139 CKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCD-GCGKKKIPREKF 202

  Fly   130 SRH---------NCVFELRELVEKLAKEVSDLKQKQSDMEEQSSSQRREMELFQYYIAALRST-- 183
            ..|         .|.|.....:|.:               |....|..|::..:.::|.|.|:
Human   203 QDHVKTCGKCRVPCRFHAIGCLETV---------------EGEKQQEHEVQWLREHLAMLLSSVL 252

  Fly   184 --NPMLRNIGEQ 193
              .|:|   |:|
Human   253 EAKPLL---GDQ 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9014	NP_001285905.1	zf-C3HC4	18..55	CDD:278524	12/51 (24%)
CG9014	NP_001285905.1	USP8_interact	137..319	CDD:286082	11/61 (18%)
TRAF2	NP_066961.2	RAD18	28..>157	CDD:333230	25/137 (18%)
		RING-HC_TRAF2	32..73	CDD:319553	10/41 (24%)
		RING-HC finger (C3HC4-type)	34..72	CDD:319553	9/38 (24%)
		zf-TRAF	178..235	CDD:280357	14/72 (19%)
		TRAF_BIRC3_bd	267..329	CDD:318808
		Important for interaction with BIRC2 and BIRC3. /evidence=ECO:0000250	283..293
		MATH_TRAF2	334..497	CDD:239747
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D918518at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820