DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9014 and RNF138

DIOPT Version :9

Sequence 1:	NP_001285905.1	Gene:	CG9014 / 34777	FlyBaseID:	FBgn0028847	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_001178253.2	Gene:	RNF138 / 51444	HGNCID:	17765	Length:	245	Species:	Homo sapiens

Alignment Length:	173	Identity:	37/173 - (21%)
Similarity:	68/173 - (39%)	Gaps:	29/173 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGFDLNCIVGHVDEELICPICTDVLEEPVQSSECEHAFCRACIDKWMIQKQI-CPVDRSGLLTSH 64
            |..||:....:.:::..||:|.:||:.||:::.|:|.|||.|....|.:... ||:.|..:....
Human     1 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRESGAHCPLCRGNVTRRE 65

  Fly    65 LVPVSRL--MRNMLSRLKIKCTFSQSGCAQMLALEEFRTHVAAC-----EHNPKVVVECSKGCGM 122
            .....|.  :.|::.:....|..    ||:.:.....|.|..:|     |:....::.     ..
Human    66 RACPERALDLENIMRKFSGSCRC----CAKQIKFYRMRHHYKSCKKYQDEYGVSSIIP-----NF 121

  Fly   123 KVPKDEMSRHNCVFELRELVEKLAKEVSDLKQKQSDMEEQSSS 165
            ::.:|.:...|            ..|.|.....::..|..|||
Human   122 QISQDSVGNSN------------RSETSTSDNTETYQENTSSS 152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9014	NP_001285905.1	zf-C3HC4	18..55	CDD:278524	15/37 (41%)
CG9014	NP_001285905.1	USP8_interact	137..319	CDD:286082	6/29 (21%)
RNF138	NP_001178253.2	RING-HC_RNF138	14..59	CDD:319458	16/44 (36%)
		zf_C2HC_14	80..112	CDD:408358	6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	125..154		8/40 (20%)
		zf-Di19	156..215	CDD:398954
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7288
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860