DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9014 and Traf6

DIOPT Version :9

Sequence 1:	NP_001285905.1	Gene:	CG9014 / 34777	FlyBaseID:	FBgn0028847	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_001101224.1	Gene:	Traf6 / 311245	RGDID:	1306853	Length:	530	Species:	Rattus norvegicus

Alignment Length:	401	Identity:	93/401 - (23%)
Similarity:	149/401 - (37%)	Gaps:	102/401 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CPICTDVLEEPVQSSECEHAFCRACIDKWMIQK-QICPVDRSGLLTSHLVPVSRLMRNMLSRLKI 81
            ||||...|.|.|| :.|.|.||:|||.|.:... ..||||...||.:.|.|.:...|.:|| |.:
  Rat    70 CPICLMALREAVQ-TPCGHRFCKACITKSIRDAGHKCPVDNEILLENQLFPDNFAKREILS-LTV 132

  Fly    82 KCTFSQSGCAQMLALEEFRTHVAACEH-----------------NPKVVVECSK------GCGMK 123
            ||  ...||.|.:.|.....|...||.                 |..::.:|.:      .|.:.
  Rat   133 KC--PNKGCVQKMELRHLEDHQVHCEFALVICPQCQRFFQKCQINKHIIEDCPRRQVSCVNCAVP 195

  Fly   124 VPKDEMSRHNCVFELRELVEKLAKEVSDLKQKQS--DMEEQSSSQRREMELFQYYIAALRSTNPM 186
            :|.:|...|:....|..::.:....:...:|..:  |::..::.......:|..:....|  |.:
  Rat   196 MPYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPVPCTFSVFGCHEKMQR--NHL 258

  Fly   187 LRNIGE--QLDRFSLMQWGHGLPL------ANIHTWGSLISTPDNPMH----------LMVRD-V 232
            .|::.|  ||....|.|..|.:.|      |:..:.|   ..|::|.:          |:.:| .
  Rat   259 ARHLQENTQLHMRLLAQAVHNVNLSLRPCDASSPSRG---CRPEDPNYEETVKQLEGRLVRQDHQ 320

  Fly   233 LRESGCPMHMLNMLVE------RCHEDRWPE-------GLMTLDDRRENQHLMSRYVTRLV---- 280
            :||....|...:|.|.      |..||:..|       |:..........||.|:...|.|
  Rat   321 IRELTAKMETQSMHVSELKRTIRSLEDKVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHS 385

  Fly   281 PGLVIGKP-----------------C-------VVVLGGE-NTHMPENLRPILGLVMIFVDGVNE 320
            ||...|:|                 |       |..:.|| ::|:|   .|..|.:.:.:...:|
  Rat   386 PGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLP---WPFQGTIRLTILDQSE 447

  Fly   321 VIF---GEEII 328
            .:.   .||::
  Rat   448 AVIRQNHEEVM 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9014	NP_001285905.1	zf-C3HC4	18..55	CDD:278524	17/37 (46%)
CG9014	NP_001285905.1	USP8_interact	137..319	CDD:286082	47/244 (19%)
Traf6	NP_001101224.1	Interaction with TAX1BP1. /evidence=ECO:0000250	1..362		73/300 (24%)
		mRING-HC-C3HC3D_TRAF6	67..124	CDD:319557	24/54 (44%)
		PLN03086	<132..219	CDD:178635	16/88 (18%)
		TRAF6_Z2	157..183	CDD:407885	1/25 (4%)
		zf-TRAF	204..261	CDD:280357	7/58 (12%)
		DUF460	<273..>352	CDD:421465	18/81 (22%)
		MATH_TRAF6	359..508	CDD:239745	21/103 (20%)
		Interaction with TANK. /evidence=ECO:0000250\|UniProtKB:Q9Y4K3	363..530		20/99 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D918518at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820