DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9014 and Traf6

DIOPT Version :9

Sequence 1:	NP_001285905.1	Gene:	CG9014 / 34777	FlyBaseID:	FBgn0028847	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_001290202.1	Gene:	Traf6 / 22034	MGIID:	108072	Length:	530	Species:	Mus musculus

Alignment Length:	431	Identity:	80/431 - (18%)
Similarity:	138/431 - (32%)	Gaps:	162/431 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 CPICTDVLEEPVQSSECEHAFCRACIDKWMIQK-QICPVDRSGLLTSHLVPVSRLMRNMLSRLKI 81
            ||||...|.|.|| :.|.|.||:|||.|.:... ..||||...||.:.|.|.:...|.:|| |.:
Mouse    70 CPICLMALREAVQ-TPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILS-LTV 132

  Fly    82 KCTFSQSGCAQMLALEEFRTHVAACEH-----------------NPKVVVECSK----------- 118
            ||  ...||.|.:.|.....|...||.                 |..::.:|.:
Mouse   133 KC--PNKGCLQKMELRHLEDHQVHCEFALVNCPQCQRPFQKCQVNTHIIEDCPRRQVSCVNCAVS 195

  Fly   119 ----------------------------------------------------GCGMKVPKDEMSR 131
                                                                ||..|:.::.::|
Mouse   196 MAYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPIPCTFSVFGCHEKMQRNHLAR 260

  Fly   132 H---NCVFELRELVE-----KLAKEVSD------------------LKQKQSDMEEQSSSQRR-- 168
            |   |....:|.|.:     .||....|                  :||.:|.:..|....|.
Mouse   261 HLQENTQLHMRLLAQAVHNVNLALRPCDAASPSRGCRPEDPNYEETIKQLESRLVRQDHQIRELT 325

  Fly   169 -EMELFQYYIAALRSTNPMLRNIGEQLDRFSLMQWGHGLPLANIHTWGSLISTPDNPMHLMVRDV 232
             :||....|:..|:.|   :|.:.:::......|. :|:.:..|..:|..:.:.:....:::...
Mouse   326 AKMETQSMYVGELKRT---IRTLEDKVAEMEAQQC-NGIYIWKIGNFGMHLKSQEEERPVVIHSP 386

  Fly   233 LRESGCP-------MHMLNMLVERCHEDRWPEGLMTLDDRRENQHLMSRYVTRLVPGLVIGKPCV 290
            ...:|.|       :|:.....:||                      :.|::..|.
Mouse   387 GFYTGRPGYKLCMRLHLQLPTAQRC----------------------ANYISLFVH--------- 420

  Fly   291 VVLGGENTHMPENLRPILGLVMIFVDGVNEVIF---GEEII 328
            .:.|..::|:|   .|..|.:.:.:...:|.:.   .||::
Mouse   421 TMQGEYDSHLP---WPFQGTIRLTILDQSEALIRQNHEEVM 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9014	NP_001285905.1	zf-C3HC4	18..55	CDD:278524	17/37 (46%)
CG9014	NP_001285905.1	USP8_interact	137..319	CDD:286082	32/214 (15%)
Traf6	NP_001290202.1	Interaction with TAX1BP1. /evidence=ECO:0000250	1..362		63/299 (21%)
		RING	69..107	CDD:238093	17/37 (46%)
		zf-TRAF	204..261	CDD:280357	3/56 (5%)
		SlyX	304..>356	CDD:294687	11/54 (20%)
		MATH_TRAF6	359..508	CDD:239745	18/134 (13%)
		Interaction with TANK. /evidence=ECO:0000250\|UniProtKB:Q9Y4K3	363..530		17/130 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D918518at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820